Calciphylaxis continues to present a clinical challenge for patient management. As in this case, it can be associated with connective tissue disease (CTD) such as systemic lupus erythematosus (SLE). Unlike previous reported cases, long-term remission has been attained. This provides some insight into methods of therapy as well as potential pathogenic models for this disease.
MandelbrotDASantosPWBurtPK. Resolution of SLE-related soft-tissue calcification following haematopoietic stem cell transplantation. Nephrol Dial Transplant2008; 23: 2679–2684.
2.
Al BeladiFI. Catastrophic calciphylaxis in a patient with lupus nephritis and recent onset of end-stage renal disease. Saudi J Kidney Dis Transpl2010; 21: 323–327.
3.
RogersNMChangSHTeubnerDJOCoatesPTH. Hyperbaric oxygen as effective adjuvant therapy in the treatment of distal calcific uraemic arteriolopathy. NDT Plus2008; 4: 244–249.
4.
WongJJLaumannAMartinezM. Calciphylaxis and antiphospholipid antibody syndrome. J Am Acad Dermatol2000; 42: 849–849.
5.
ZechlinskiJJAngelJR. Calciphylaxis in the absence of renal disease: secondary hyperparathyroidism and systemic lupus erythematosus. J Rheumatol2009; 36: 2370–2371.
6.
KiforOMcElduffALeBoffMS. Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab2004; 89: 548–556.
7.
IgakiNMoriguchiRHirotaY. Calciphylaxis in a patient with end-stage renal disease secondary to systemic lupus erythematosus associated with acral gangrene and mesenteric ischemia. Intern Med2001; 40: 1232–1237.
8.
SloughSServillaKSHarfordAMKonstantinovKNHarrisATsamaloukasAH. Association between calciphylaxis and inflammation in two patients on chronic dialysis. Adv Perit Dial2006; 22: 171–174.
9.
LeeJLNaguwaSMCheemaGGershwinME. Recognizing calcific uremic arteriolopathy in autoimmune disease: an emerging mimicker of vasculitis. Autoimmun Rev2008; 7: 638–643.
10.
SelyeHGabbianiGStrebelR. Sensitization to calciphylaxis by endogenous parathyroid hormone. Endocrinology1962; 71: 554–558.
11.
WilmerWAMagroCM. Calciphylaxis: emerging concepts in prevention, diagnosis, and treatment. Semin Dial2002; 15: 172–186.
12.
RogersNMTeubnerDJCoatesPT. Calcific uremic arteriolopathy: advances in pathogenesis and treatment. Semin Dial2007; 20: 150–157.
13.
HaydenMRGoldsmithDJ. Sodium thiosulfate: new hope for the treatment of calciphylaxis. Semin Dial2010; 23: 258–262.
14.
FarahMCrawfordRILevinAChan YanC. Calciphylaxis in the current era: emerging ‘ironic’ features?Nephrol Dial Transplant2011; 26: 191–195.
