Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis, recurrent fetal losses or other pregnancy complications, and the presence of antiphospholipid antibodies (aPL). Ocular manifestations occur in 8—88% of patients with APS and are typically due to vaso-occlusive disease involving retinal and choroidal vessels. We report an unusual case of neuroretinitis as a first presentation of lupus-like illness with APS. Lupus (2010) 19, 1662—1664.
Miyakis S., Lockshin MD, Atsumi T., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost2006; 4: 295-306.
2.
Roubey RAMechanisms of autoantibody-mediated thrombosis. Lupus1998; 7: S114-S119.
3.
Asherson RA, Cervera R.The antiphospholipid syndrome: a syndrome in evolution. Ann Rheum Dis1992; 51: 147-150.
4.
Castanon C., Amigo MC, Banales JL, et al. Ocular vaso-occlusive disease in primary antiphospholipid syndrome . Ophthalmology1995; 102: 256-262.
5.
Durrani M, Gordon C., Murray PIPrimary anti-phospholipid antibody syndome (APS): current concepts. Survey Ophthalmology2002; 47: 215-238.
Gelfand YA, Dori D., Miller B., Brenner B.Visual disturbances and pathological ocular findings in primary antiphospholipid syndrome. Ophthalmology1999; 106: 1537-1540.
8.
Tan BE, Thong BY, Shivananda S., Han WW, Chng HHClinical manifestations and outcomes of antithrombotic treatment of the Tan Tock Seng Hospital Singapore antiphospholipid syndrome cohort. Lupus2009; 18: 752-758.
9.
Yoon KH, Fong KY, Sivalingam P., et al. Antiphospholipid syndrome in Asians: clinical manifestations, serological markers and outcome of the National University of Singapore/National University Hospital antiphospholipid cohort. APLAR J Rheumatol2003; 6: 128-136.
10.
Brazis PW, Lee AGOptic disk edema with a macular Star. Mayo Clinic Proc1996; 71: 1162-1166.
11.
Maitland CG , Miller NRNeuroretinitis. Arch Ophthalmol1984; 102: 1146-1150.
12.
Walsh FB, Hoyt WF, Neuroretinitis. In: Clinical Neuro-ophthalmology, 4th ed. Baltimore, MD: Williams and Wilkins; 2005. p. 333-336.