Severe liver involvement requiring liver transplantation is a rare complication in systemic lupus erythematosus (SLE), but very few cases have been reported. We describe a 39-year-old woman with SLE who underwent successful liver transplantation due to acute liver failure. The patient persisted without reactivation of SLE and with good long-term survival. Management and diagnosis considerations are reviewed.
ChowdharyVRCrowsonCSPoteruchaJJModerKG. Liver involvement in systemic lupus erythematosus: case review of 40 patients. J Rheumatol2008; 35: 2159–2164.
2.
BarthelHRWallaceDJKlinenbergJR. Liver transplantation in patients with systemic lupus erythematosus. Lupus1995; 4: 15–17.
3.
LianECTzakisAGAndrewsD. Response of factor V inhibitor to rituximab in a patient who received liver transplantation for primary biliary cirrhosis. Am J Hematol2004; 77: 363–365.
4.
MackayIRTaftLICowlingDC. Lupoid hepatitis and the hepatic lesions of systemic lupus erythematosus. Lancet1959; 7063: 65–69.
RunyonBALeBrecqueDRAnurasS. The spectrum of liver disease in systemic lupus erythematosus. Report of 33 histologically-proved cases and review of the literature. Am J Med1980; 69: 187–194.
7.
MillerMHUrowitzMBGladmanDDBlendisLM. The liver in systemic lupus erythematosus. Q J Med1984; 53: 401–409.
8.
LeggettBA. The liver in systemic lupus erythematosus. J Gastroenterol Hepatol1993; 8: 84–88.
9.
Van HoekB. The spectrum of liver disease in systemic lupus erythematosus. Neth J Med1996; 48: 244–253.
10.
MatsumotoTYoshimineTShimouchiKShiotuHKuwabaraNFukudaYHoshiT. The liver in systemic lupus erythematosus: pathologic analysis of 52 cases and review of Japanese Autopsy Registry Data. Hum Pathol1992; 23: 1151–1158.
11.
ArnettFCReichlinM. Lupus hepatitis: an under-recognized disease feature associated with autoantibodies to ribosomal P. Am J Med1995; 99: 465–472.
12.
IrvingKSSenDTahirHPilkingtonCIsenbergDA. A comparison of autoimmune liver disease in juvenile and adult populations with systemic lupus erythematosus-a retrospective review of cases. Rheumatology (Oxford)2007; 46: 1171–1173.
13.
PistinerMWallaceDJNessimSMetzgerALKlinenbergJR. Lupus erythematosus in the 1980s: a survey of 570 patients. Semin Arthritis Rheum1991; 21: 55–64.
14.
HallSCzajaAJKaufmanDKMarkowitzHGinsburgWW. How lupoid is lupoid hepatitis?J Rheum1986; 13: 95–98.
VerdonkRCvan den BergAPSlooffMJPorteRJHaagsmaEB. Liver transplantation: an update. Neth J Med2007; 65: 372–380.
17.
MaileyBBuchbergBPrendergastCArtinyanAKhalilJSanchez-Luege. A disease-based comparison of liver transplantation outcomes. Am Surg2009; 75: 901–908.
18.
LidofskySD. Liver transplantation for fulminant hepatic failure. Gastroenterol Clin North Am1993; 22: 257–257.
19.
Giner GalvañVOltraMRRuedaDEstebanMJRedónJ. Severe acute hepatitis related to hydroxychloroquine in a woman with mixed connective tissue disease. Clin Rheumatol2007; 26: 971–972.
20.
WiesnerRHDemetrisAJBelleSHSeabergECLakeJRZettermanRK. Acute hepatic allograft rejection: incidence, risk factors, and impact on outcome. Hepatology1998; 28: 638–645.
21.
NeubergerJAdamsDH. What is the significance of acute liver allograft rejection?J Hepatol1998; 29: 143–143.
22.
AtsumiTSagawaSJodoSAmasakiYNakabayashiTOhnishiK. Severe hepatic involvement without inflammatory changes in systemic lupus erythematosus: report of two cases and review of the literature. Lupus1995; 4: 225–228.
