Pulmonary hemorrhage is a rare and life-threatening complication of systemic lupus erythematosus. In this report, we described a 17-year-old female with pulmonary hemorrhage as an initial manifestation of systemic lupus erythematosus, along with lupus nephritis and central nervous system lupus. High doses of corticosteroids and pulse cyclophosphamide therapy resulted in rapid improvement of respiratory function in our patient.
Petty ER, Laxer RMTextbook of pediatric rheumatology. In: Cassidy TJ, Petty ER (eds), Systemic lupus erythematosus. Philadelphia: WB Saunders Company;2005. p. 342-391.
2.
Badsha H., Teh CL, Kong KO, Lian TY, Chng HHPulmonary hemorrhage in systemic lupus erythematosus. Semin Arthritis Rheum2004; 33: 414-421.
3.
Santos-Ocampo AS, Mandell BF, Fessler BJAlveolar hemorrhage in systemic lupus erythematosus: presentation and management. Chest2000; 118: 1083-1090.
4.
Dweik RA, Arroliga AC, Cash JMAlveolar hemorrhage in patients with rheumatic disease. Rheum Dis Clin North Am1997; 23: 395-410.
5.
Pego-Reigosa JM, Medeiros DA, Isenberg DARespiratory manifestations of systemic lupus erythematosus: old and new concepts. Best Pract Res Clin Rheumatol2009; 23: 469-480.
6.
Zamora M., Warner ML, Tuder R., Schwarz MIDiffuse alveolar hemorrhage and systemic lupus erythematosus: clinical presentation, histology, survival, and outcome. Medicine1997; 76: 192-202.
7.
Rojas-Serrano J., Pedroza J., Regalado J., et al. High prevalence of infections in patients with systemic lupus erythematosus and pulmonary haemorrhage. Lupus2008; 17: 295-299.
8.
Santiago-Casas Y., Vila LMPulmonary hemorrhage in patients with systemic lupus erythematosus. Curr Resp Med Rev2009 ; 5: 49-54.
9.
Wu CY, Chiou YH, Chiu PC, Hsieh KSSevere pulmonary hemorrhage as the initial manifestation in systemic lupus erythematosus with active nephritis. Lupus2001; 10: 879-882.
10.
Moradinejad MHTreatment of intractable pulmonary hemorrhage in two patients with childhood systemic lupus erythematosus. Rheumatol Int2009; 29: 1113-1115.
11.
Pinto LF, Candia L., Garcia P., et al. Effective treatment of refractory pulmonary hemorrhage with monoclonal anti-CD20 antibody (rituximab). Respiration2009; 78: 106-109.
12.
Narshi CB, Haider S., Ford CM, Isenberg DA, Giles IPRituximab as early therapy for pulmonary haemorrhage in systemic lupus erythematosus . Rheumatology2010; 49: 392-394.
