Systemic lupus erythematosus (SLE) is a multiorganic autoimmune disease that affects skin, osteoarticular and kidney frequently. Rituximab showed efficacy in treatment of osteoarticular and haematological SLE, but its use has been generalised for renal disease. In our case, we showed efficacy of rituximab in SLE articular disease, showing an ultrasonographic improvement.
1 Zoma A . Musculoskeletal involvement in systemic lupuserythematosus. Lupus2004; 13: 851–853.
2.
2 Smith KG Jones RB Burns SM Jayne DR . Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: remission, relapse, and retreatment. Arthritis Rheum2006; 54: 2970–2982.
3.
3 Leandro MJ Cambridge G Edwards JC Ehrenstein MR Isenberg DA . B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients. Rheumatology (Oxford)2005; 44: 1542–1545 Epub 2005 Sep 27.
4.
4 Cohen SB Emery P Greenwald MW . REFLEX Trial Group.Rituximab for rheumatoid arthritis refractory to anti-tumour necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum2006; 54: 2793–2806.
5.
5 Wakefield RJ Balint PV Szkudlarek M . OMERACT 7 Special Interest Group. Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol2005; 32: 2485–2487.
6.
6 Naredo E Bonilla G Gamero F Uson J Carmona L Lafon A . Assessment of inflammatory activity in rheumatoid arthritis: a comparative study of clinical evaluation with grey scale and power Doppler ultrasonography. Ann Rheum Dis2005; 64: 375–381.
7.
7 Naredo E Collado P Cruz A . Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression. Arthritis Rheum2007; 57: 116–124.
8.
8 Ozgocmen S Kiris A Kocakoc E Ardicoglu O Kamanli A . Evaluation of metacarpophalangeal joint synovitis in rheumatoid arthritis by power Doppler technique: relationship between synovial vascularization and periarticular bone mineral density. Joint Bone Spine2004; 71: 384–388.
9.
9 Walther M Harms H Krenn V Radke S Faehndrich TP Gohlke F . Correlation of power Doppler sonography with vascularity of the synovial tissue of the knee joint in patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum2001; 44: 331–338.
10.
10 Walther M Harms H Krenn V Radke S Kirschner S Gohlke F . Synovial tissue of the hip at power Doppler US: correlation between vascularity and power Doppler US signal. Radiology2002; 225: 225–231.
11.
11 Ribbens C André B Marcelis S . Rheumatoid hand joint synovitis: gray-scale and power Doppler US quantifications following anti-tumor necrosis factor-alpha treatment: pilot study. Radiology2003; 229: 562–569.
12.
12 Filippucci E Iagnocco A Salaffi F Cerioni A Valesini G Grassi W . Power Doppler sonography monitoring of synovial perfusion at the wrist joints in patients with rheumatoid arthritis treated with adalimumab. Ann Rheum Dis2006; 65: 1433–1437.
13.
13 Wright S Filipucci E Grassi W Grey A Bell A . Hand arthritis in systemic lupus erythematosus: an ultrasound pictorial essay. Lupus2006; 15: 501–506.
14.
14 Iagnocco A Ossandon A Coari G . Wrist joint involvement in systemic lupus erythematosus. An ultrasonographic study. Clin Exp Rheumatol2004; 22: 621–624.
15.
15 Gottenberg JE Guillevin L Lambotte O . Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases. Ann Rheum Dis2005; 64: 913–920.