Association of pernicious anemia and systemic lupus erythematosus is rare, although both diseases are autoimmune origin. We describe the case of a 40-year old man with systemic lupus erythematosus (SLE) who developed pernicious anemia. The cobalamin deficiency was revealed by macrocytic pancytopenia. After 1 month of vitamin B12 treatment, hemoglobin and white blood cell count remain normal but thrombocytopenia persists and was considered as immunologic from SLE origin requiring corticosteroids. Lupus (2007) 16, 827—829.
Tan EM, Cohen AS, Fries JF et al. The 1982 revisited criteria for the classification of systemic lupus erythematosus. Arthritis Rheum1982; 25: 1271—1277.
5.
Hamilton DVSystemic lupus erythematosus in a patient with Hashimoto's thyroidits and pernicious anemia. J R Soc Med1978; 71: 147—149.
6.
Hillion D., Zittoun J., Alvarez M. et al. Une observation d'anémie de Biermer et de lupus érythémateux disséminé. Rev Med Intern1983; 4: 65—67.
7.
Costello C., Abdelaal M., Coomes ENPernicious anemia associated with systemic lupus erythematosus in a young woman. J Rheumatol1985; 12: 798—799.
Levene NA, Buskila D., Dvilansky A. et al. Pernicious anemia in a patient with systemic lupus erythematosus. IsraelMed Sci1987; 23: 846—847.
10.
Feld S., Landau Z., Gefel D. et al. Pernicious anemia, Hashimoto's thyroiditis and Sjogren's in a woman with SLE and auto-immune haemolytic anemia. J Rheumatol1989; 16: 258—259.
11.
Junca J., Cuxart A., Tural C. et al. Systemic lupus erythematosus and pernicious anemia in a 82-year-old woman. J Rheumatol1991; 18: 1924—1925.
12.
Durand JM, Cretel E., Juhan V. et al. Systemic lupus erythematosus associated with pernicious anemia . Clin Exp Rheumatol1994; 12: 233.
13.
Shil YL, Chang DMExcellent effect of steroid plus azathioprine in a young woman with pernicious anemia and systemic lupus erythematosus. Clin Rheumatol2000; 19: 492—494.
14.
Molad Y., Rachmilewitz B., Sidi Y. et al. Serum cobalamin and transcobalamin levels in systemic lupus erythematosus . Am J Med1990; 88: 141—144.
15.
Junca J., Cuxart A., Olive A. et al. Anti-intrinsic factor antibodies in systemic lupus erythematosus . Lupus1993; 2: 111—114.
16.
Bagett RT, Welsh JDObservations on the effects of glucocorticoid administration in pernicious anemia. Am J Dig Dis1970; 15: 871—881.
