A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Parkinsonism in lupus has been reviewed. Lupus (2007) 16, 572—575.
Yancey CL , Doughty RA , Athreya BHCentral nervous system involvement in childhood systemic lupus erythematosus . Arthritis Rheum1981; 24: 1389—1395 .
2.
Steinlin MI , Blaster SI , Gilday DL et al. Neurologic manifestations of systemic lupus erythematosus . Pediatr Neurol1995; 13: 191—197 .
3.
Garcia-Moreno JM , Chacon J.Juvenile Parkinsonism as a manifestation of systemic lupus erythematosus: case report and review of the literature . Mov Disord2002; 17: 1329—1335 .
4.
Ramos PC , Mendez MJ , Ames PR , Khamashta MA , Hughes GRPulse cyclophosphamide in the treatment of neuropsychiatric systemic lupus erythematosus . Clin Exp Rheumatol1996; 14: 295—299 .
5.
Walker RH , Spiera H. , Brin MF , Olanow CWParkinsonism associated with Sjogren's syndrome: three cases and a review of the literature . Mov Disord1999; 14: 262—268 .
6.
Martino D. , Chew NK , Mir P. , Edwards MJ , Quinn NP , Bhatia KPAtypical movement disorders in antiphospholipid syndrome . Mov Disord2006; 21: 944—949 .
7.
Seminario C. , Pesano J.Cuatro casos clinicos de lupus eritematoso agudo . Sem Med (B Air)1930; 2: 721—730 .
8.
Chacon J. , Garcia-Moreno JM , Redondo L. et al. Enfermedad de Parkinson de inicio juvenil con lupus eritematoso sistemico en estadio presintomatico . Rev Neurol1999; 29: 725—727 .
9.
Moore PM , Lisak RPSystemic Lupus Erythematosus: immunopathogenesis of neurological dysfunction . Springer Semin Immunopathol1995; 17: 43—60 .
10.
Kunas RC , McRae A. , Kesselring J. , Villiger PMAntidopaminergic antibodies in a patient with a complex autoimmune disorder and rapidly progressing Parkinson's disease . J Allergy Clin Immunol1995; 96: 688—690 .
11.
Bluestein HG , Williams GW , Steinberg ADCerebrospinal fluid antibodies to neuronal cells: association with neuropsychiatric manifestations of systemic lupus eryuthematosus . Am J Med1981; 70: 240—246 .
12.
Golombeck SJ , Graus F. , Elkon KBAutoantibodies in the cerebrospinal fluid of patients with systemic lupus erythematosus . Arthritis Rheum1986; 29: 1090—1097 .
13.
Hirano T. , Hashimoto H. , Shiokawa Y. et al. Antiglycolipid autoantibody detected in the sera from systemic lupus erythematosus patients . J Clin Invest1980; 66: 1437—1440 .
14.
Mogi M. , Harada, M. , KondoT. et al. Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients . Neurosci Lett1994; 180: 147—150 .
15.
Kluter H. , Vieregge P. , Stolze H. , Kirchner H.Defective production of interleukin-2 in patients with idiopathic Parkinson's disease . J Neurol Sci1995; 133: 134—139 .
16.
Shahar E. , Goshen E. , Tauber Z. , Lahat E.Parkinsonian syndrome complicating systemic lupus erythematosus . Pediatr Neurol1998; 18: 456—458 .
17.
Kwong KL , Chu R. , Wong SNParkinsonism as unusual neurological complication in childhood systemic lupus erythematosus . Lupus2000; 9: 474—477 .
18.
Lee PS , Joo US , Bang OY , Seo CHBasal ganglia hyperperfusion in a patient with systemic lupus erythematosus-related Parkinsonism . Neurol2004; 63: 395—396 .
19.
Tan EK , Chan LL , Auchus APReversible Parkinsonism in systemic lupus erythematosus . J Neurol Sci2001; 193: 53—57 .
20.
Furmaga KM , DeLeon OA , Jobe TH , Gaviria MPPsychosis in medical conditions: response to risperidone . Gen Hosp Psychiatry1997; 19: 223—228 .