The aim of this study was to assess the possible association between the p53 suppressor gene codon 72 polymorphism and systemic lupus erythematosus (SLE). Our study population consisted of 513 SLE patients and 567 healthy controls. All the individuals were of Spanish Caucasian origin. Genotyping of the p53 codon 72 polymorphism was performed by allele-specific PCR. No statistically significant differences were observed between SLE patients and healthy controls when p53 codon 72 genotype and allele frequencies were compared. In addition, no evidence for association with clinical subfeatures of SLE was found. In conclusion, the p53 codon 72 polymorphism associated with SLE in a Korean population does not appear to play a major role in the susceptibility or severity of SLE in the Spanish population.
Tsao BP . The genetics of human systemic lupus erythematosus . Trends Immunol2003; 24: 595–602 .
2.
White S , Rosen A.Apoptosis in systemic lupus erythematosus . Curr Opin Rheumatol2003; 15: 557–562 .
3.
Kovacs B , Patel A , Hershey JN , Dennis GJ , Kirschfink M , Tsokos GC . Antibodies against p53 in sera from patients with systemic lupus erythematosus and other rheumatic diseases . Arthritis Rheum1997; 40: 980–982 .
4.
Levine AJ . p53, the cellular gatekeeper for growth and division . Cell1997; 88: 323–331 .
5.
Johansson CM , Zunec R , Garcia MA et al. Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus . Hum Genet2004; 115: 230–238 .
6.
Matlashewski GJ , Tuck S , Pim D , Lamb P , Schneider J , Crawford LV . Primary structure polymorphism at amino acid residue 72 of human p53 . Mol Cell Biol1987; 7: 961–963 .
7.
Storey A , Thomas M , Kalita A et al. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer . Nature1998; 393: 229–234 .
8.
Dumont P , Leu JI , Della Pietra AC 3rd , George DL , Murphy M.The codon 72 polymorphic variants of p53 have markedly different apoptotic potential . Nat Genet2003; 33: 357–365 .
9.
Kawajiri K , Nakachi K , Imai K , Watanabe J , Hayashi S.Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer . Carcinogenesis1993; 14: 1085–1089 .
10.
Jin X , Wu X , Roth JA et al. Higher lung cancer risk for younger African Americans with the Pro/Pro p53 genotype . Carcinogenesis1995; 16: 2205–2208 .
11.
Sjalander A , Birgander R , Athlin L et al. P53 germ line haplotypes associated with increased risk for colorectal cancer . Carcinogenesis1995; 16: 1461–1464 .
12.
Ohayon T , Gershoni-Baruch R , Papa MZ , Distelman Menachem T , Eisenberg Barzilai S , Friedman E.The R72P P53 mutation is associated with familial breast cancer in Jewish women . Br J Cancer2005; 92: 1144–1148 .
13.
Lee YH , Rho YH , Choi SJ , Ji JD , Song GG . The functional p53 codon 72 polymorphism is associated with systemic lupus erythematosus . Lupus2005; 14: 842–845 .
14.
Chauhan R , Handa R , Das TP , Pati U.Over-expression of TATA binding protein (TBP) and p53 and autoantibodies to these antigens are features of systemic sclerosis, systemic lupus erythematosus and overlap syndromes . Clin Exp Immunol2004; 136: 574–584 .
15.
Hochberg MC . Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus . Arthritis Rheum1997; 40: 1725–1725 .
16.
Ioannidis JP , Ntzani EE , Trikalinos TA , Contopoulos-Ioannidis DG . Replication validity of genetic association studies . Nat Genet2001; 29: 306–309 .
17.
To-Figueras J , Gene M , Gomez-Catalan J et al. Glutathione-S Transferase M1 and codon 72 p53 polymorphisms in a northwestern Mediterranean population and their relation to lung cancer susceptibility . Cancer Epidemiol Biomarkers Prev1996; 5: 337–342 .
18.
Martinez-Lucas P , Moreno-Cuesta J , Garcia-Olmo DC et al. Relationship between the Arg72Pro polymorphism of p53 and outcome for patients with traumatic brain injury . Intensive Care Med2005; 31: 1168–1173 .
19.
Prokunina L , Castillejo-Lopez C , Oberg F et al. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans . Nat Genet2002; 32: 666–669 .
20.
Lin SC , Yen JH , Tsai JJ et al. Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus . Arthritis Rheum2004; 50: 770–775 .
21.
Suzuki A , Yamada R , Chang X et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis . Nat Genet2003; 34: 395–402 .
22.
Barton A , Bowes J , Eyre S et al. A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population . Arthritis Rheum2004; 50: 1117–1121 .
23.
Tokuhiro S , Yamada R , Chang X et al. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis . Nat Genet2003; 35: 341–348 .
24.
Barton A , Eyre S , Bowes J , Ho P , John S , Worthington J.Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients . Arthritis Rheum2005; 52: 752–758 .
25.
Orozco G , Sanchez E , González-Gay MA et al. SLC22A4, RUNX1 and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population . J Rheumatol2006; 33: 1235–1239 .
