Proceedings of the British Toxicology Society Annual Congress University of Surrey,Guildford 19 - 22 April 1998

Luster, M. I. , Portier, C. , Pait, D. G. , White, K. L., Jr. , Gennings, C. , Munson, A. E. & Rosenthal, G. J. (1992) Fundam. Appl. Toxicol. 18, 200-210 .

Luster, M. I. , Portier, C. , Pait, D. G. , Rosenthal, G. J. , Germolec. D. R. , Corsini, E. , Blaylock, B. L. , Pollock, P. , Kouchi, Y. , Craig, W. , White, D. L. , Munson, A. E. & Comment, C. E. (1993) Fundam. Appl. Toxicol. 21, 71-82 .

Selgrade, M. J. K. (1998) Toxicol. In Press.

Kimber, I. , Dearman, R. J. , Scholes, E. W. & Basketter, D. A. (1994) Toxicology 93, 13-31 .

Hilton, J. , Dearman, R. J , Boylett, M. S. , Fielding, I. , Basketter, D. A. & Kimber, I. (1996) J. Appl. Toxicol. 16, 165-170

Kimber, I. & Dearman, R. J. (1997) Clin. Rev. Allergy Immunol. 15, 145-168

Dearman, R. J. , Basketter, D. A. & Kimber, I. (1996) TOxicol. Appl. Pharmacol. 138, 308-316 .

Report of a WHO Scientific Group (1997). Clin.Exp.Immunol. 109, Suppl. 1, 1-28 .

Rosen, F. S. , Cooper, M. D. & Wedgwood, R. J. P. (1995). New Eng. J. Med. 333, 431-440 .

Fischer, A. , De Saint Bastille, G. , Disanto J. R , et al (1997) Adv. Nephrol. 26, 107-120 .

Matsuzawa T. , Hashimoto M. , Nara H. , Yoshida M. ., Tamura S. and Igarashi T. (1997) In Current Status of Conducting Function Tests in Repeated Dose Toxicity Studies in Japan Journal of Toxicological Sciences: 22 (5): 375-382 (1997)

Herber R. F. M. (1996) Toxicokinetics and Toxicodynamics - I. In Fundamental Toxicology for Chemists ed. Duffus J. H. and Worth H. G. J. pp. 17-25 The Royal SOciety of Chemistry

Boyett, M. R. , Harrison, SM. , Janvier, N. et al. (1996) Cardiovasc. Res. 32, 455-481 .

Noma, A. (1996) Jpn Heart J. 37, 673-682 .

Doll, R. & Peto, R. (1981) J. Natl. Cancer Inst. 66, 1191-1309 .

Lutz, W. K. & Schlatter, J. (1992) Carcinogenesis 13, 2211-2216 .

Hart, R. W. , Neumann, D. A. & Robertson, R. T. , eds. (1995) Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies. 396-396 pp. Washington DC: ILSI Press .

Sugimura, T. , Science, 258, 603-607 (1992)

Ohgaki, H. et al. , Mutat. Res., 259, 399-410 (1991)

Sugimura, T. , Mutat. Res., 376, 211-219 (1997)

Kakiuchi, H. et al. , Proc. Natl. Acad. Sci. USA, 92, 910-914 (1995)

Dashwood, R. H. et al. , Cancer Res., in press

Mirvish, S. S. (1995) Cancer Lett. 93, 17-48

Correa, P. (1992) Cancer Res. 52, 6735-6740

Bingham, S. A. , Pignatelli, B. , Pollock, J. , Ellul, A. , Mallaveille, C. , Gross, G. , Runswick, S. , Cummings, J. H. , & O'Neill, I. K. , (1996) Carcinogenesis. 17, 515-523

Sedgwick, B. (1997) Carcinogenesis. 18, 1561-1567

Challis, B. C. (1989) Cancer Surveys, 8, 363-384

Shuker, D. E. G. , & Margison, G. P. , (1997) Cancer Res. 57, 366-369

Harrison, K. L. , Fairhurst, N. , Challis, B. C. , & Shuker, D. E. G. , (1997) Chem. Res. Tox., 10, 652-659

Harrison, K.L., Jukes, R., Cooper, D.P., & Shuker, D.E.G., Manuscript in preparation.

Harrison, K.L., & Shuker, D.E.G., Manuscript in preparation

Halliwell, B. (1996) Free Rad. Res. 25, 57-74 .

Jenner, A. , England, T. G. , Aruoma, O. I. and Halliwell, B. (1998) Biochem. J. in press.

Block, G. , Patterson, B. , & Subar, A. (1992) Nutr. Cancer, 18, 1-29 .

Huttunen, J. K. (1996) In: Chemoprevention in Cancer Control.' Eds. Hakama, M. , et al., IARC Publication. pp 63-65. Lyon .

Hayes, J. H. , Ellis, E. M. , Neal, G. E. , Harrison, D. J. & Manson, M. M. (1998) In `Cellular Stress Responses' Eds Downes, C. P. & Wolf, C. R. , Portland Press, London , (in press)

Gescher, A. , Pastorino, U. , Plummer, S. M. , & Manson, M. M. (1998) Brit. J. Clin. Pharmacol. 45, 1-12 .

Brown, N. A. et al. (1995) ATLA 23, 868-882

ICH Harmonised Tripartite Guideline: Reproductive Toxicity (1993)

OECD 414: Prenatal Developmental Toxicity (Draft, 1996)

EPA OPPTS 870.3700: Prenatal Developmental Toxicity (Draft, 1996)

EPA 540/07-91-123 Series 83-6: Developmental Neurotoxicity Study (1991)

Maden, M. (1998) In Retinoids: Handbook of Experimental Pharmacology eds. Nau, H. & Blaner, W. S. (in press). Heidelberg: Springer-Verlag .

Lammer, E. J. & Armstrong, D. L. (1992) In Retinoids in Normal Development and Teratogenesis ed. Morriss-Kay G. pp281-295, Oxford: Oxford University Press .

Gale, E. , Prince, V. , Lumsden, A. , Clarke, J. , Holder, N. & Maden, M. (1996) Development 122, 783-793 .

Maden, M. , Gale, E. , Kostetskii, I. & Zile, M. H. (1996) Current Biol. 6, 417-426 .

Bernfield, M. (1990). Developmental biology: Preventive medicine for neonatology . Pediatr. Res. 27(Suppl), S21-S27 .

Copp, A. J. (1994). Birth defects - from molecules to mechanisms . J. Roy. Coll. Phys. 28, 294-300 .

Fleming, A. , Gerrelli, D. , Greene, N. D. E. & Copp, A. J. (1997). Mechanisms of normal and abnormal neurulation: evidence from embryo culture studies . Int. J. Dev. Biol. 41, 199-212 .

Copp, A. J. & Bernfield, M. (1994). Etiology and pathogenesis of human neural tube defects: Insights from mouse models . Curr. Opin. Pediatr. 6, 624-631 .

Wald, N. , Sneddon, J. , Densem, J. , Frost, C. , Stone, R. & MRC Vitamin Study Res Group . (1991). Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study . Lancet 338, 131-137 .

Greene, N. D. E. & Copp, A. J. (1997). Inositol prevents folate-resistant neural tube defects in the mouse . Nature Med. 3, 60-66 .

Morgane PJ , Austin-LaFrance RJ , Bronzino JD , Tonkiss J & Galler JR (1992) Malnutrition in the developing central nervous system. In: The vulnerable brain and environmental risks, Plenum Press .

Rodier PM (1994) Comparative postnatal neurological development. In Prenatal Exposure to Neuroteratogens. Johns Hopkins University Press .

Rosengarten H & Friedhoff AJ (1979) Enduring changes in dopamine receptors of pups from drug administration to pregnant and nursing rats . Science 203, 1133-1135 .

Tikkanen, M. J. , Wähälä, K. , Ojala, S. , Vihma, V. & Adlercreutz, H. (1998) Proc. Natl. Acad. Sci., in press.

Adlercreutz, H. & Mazur, W. (1997) Ann. Med. 29, 95-120 .

Guengerich, F. P. (1995) In Cytochrome P450 ed. Ortiz de Montellano, P. R. pp. 473-535. New York: Plenum .

Guengerich, F. P. , Gillam, E. M. J. & Shimada, T. (1996) Crit. Rev. Toxicol. 26, 551-583 .

Parikh, A. , Gillam, E. M. J. & Guengerich, F. P. (1997) Nature Biotechnol. 15, 784-788 .

Josephy, P. D. , Evans, D. H. , Parikh, A. , & Guengerich, F. P. (1998) Chem. Res. Toxicol. 11, 70-74 .

Bell, L. C. & Guengerich, F. P. (1997) J. Biol. Chem. 272, 29643-29651 .

Gonzalez, F. J. & Gelboin, H. V. (1993). J. Toxicol. Envron. Health 40, 289-308 .

Gonzalez, F. J. & Gelboin, H. V. (1994). Drug Metab. Rev. 26, 165-183 .

Crespi, C. L. , Gonzalez, F. J. , Steimel, D. T. , Turner, T. R. , Gelboin, H. V. , Penman, B. W. & Langenbach, R. (1991). Chem. Res. Toxicol. 4, 566-572 .

Crespi, C. L. (1995). Advances in Drug Research. ( Meyer, U. A. and Testa, B. Eds.) Academic Press, New York . 179-235.

Smith, G. , Stanley, L. A. , Sim, E. , Strange, R. C. & Wolf, C. R. (1995) Cancer Surveys 25, 27-65 .

Tucker, G. T. (1994) J. Pharmac. Pharmacol. 46, 417-424 .

Hainzl, D. & Casida, J. E. (1996) Proc. Natl. Acad. Sci. USA, 93, 12764-12767

Mahajna, M. Quistad, G. B. & Casida, J. E. (1997) Chem. Res. Toxicol., 10, 64-69

Mahajna, M. & Casida, J. E. (1998) Chem. Res. Toxicol. 11, 26-34

Chao, S. L. & Casida, J. E. (1997) Pestic. Biochem. Physiol., 58, 77-88

Fang, N. , Rowlands, J. C. & Casida, J. E. (1997) Chem. Res. Toxicol., 10, 853-858

Rowlands, J.C. & Casida, J.E. (1998), submitted

Jefferies, P.R., Quistad, G.B. & Casida, J.E. (1998), submitted

Hill, A. B. , Jefferies, P. R. , Quistad, G. B. & Casida, J. E. (1997) Mutation Res., 395, 159-171

Birchfield, N. B. & Casida, J. E. (1996) Chem. Res. Toxicol., 9, 1135-1139

Birchfield, N. B. & Casida, J. E. (1997) Pestic. Biochem. Physiol., 57, 36-43

Li, Y.-M. & Casida, J. E. (1992) Proc. Natl. Acad. Sci. USA, 89, 11867-11870

Laidley, C. W. , Cohen, E. & Casida, J. E. (1997) J. Pharmacol. Exp. Ther., 280, 1152-1158

Staub, R.E., Quistad, G.B. & Casida, J.E. (1998), submitted.

Marrs T. C. (1996) Toxic Substance Mechanisms 15, 357-388 .

Niven K.J.M., Scott A.J., Hagen S., Waclawski E.R., Lovett M., et al (1993) Institute of Occupational Medicine Technical Memorandum TM/93/03.

Rees H. (1996) Occup & Environ Med 53, 258-263 .

Stephens R. , Spurgeon A. , Calvert I. A. , Beach J. , Levy L. S. , et al (1995) Lancet 345, 1135-1139 .

Beach J. R. , Spurgeon A. , Stephens R. , Heafield T. , Calvert I. A. , et al (1996) Occup Environ Med 53, 520-525 .

Behan P. O. (1996) J Nut Env Med 6, 341-350

Hokkanen, H. M. T. & Lynch, J. M. (eds) (1995) Biological Control: Benefits and Risks. Cambridge University Press .

Lynch, J. M. & Wiseman, A. (eds) (1998) Environmental Biomonitoring: The Biotechnology Ecotoxicology Interface. Cambridge University Press .

Peroutka, S. J. (1987) New.Eng.J.Med. 317, 1542-1543 .

Henry, J. A. , Jeffreys, K. J. , Dawling, S. (1992) Lancet. 340, 384-387 .

Maxwell, D. L. , Polkey, M. J. , & Henry, J. A. (1993) British Medical Journal. 307, 1399-1399 .

Holden, R. , Jackson, M. A. (1996) Lancet. 347, 1052-1052 .

Iovino, M. , Steardo, L. (1985) European Journal of Pharmacology. 133, 99-103 .

McElhatton, P. R. , Bateman, D. N. , Evans, C. , Pughe, K. R. , & Worsley A. J. Br J Clin Pharmacol. 45, 184-184 .

McGuire, P. K. , Cope, H. , Fahy, T. A. (1994) Br J Psych. 165, 391-395 .

Green, R. A. , Cross, A. J. , & Goodwin, G. M. (1995). Psychopharmacol. 119, 247-260 .

Substance Abuse . A comprehensive textbook. 3rd Edition. Eds. Lowinson JH , Ruiz P. Millman RB , Langrod JG. London Williams and Wilkins . 1997.

Drummer OH , Opeskin K , Syrjanen M , Cordner S. Methadone toxicity causing death in ten subjects starting on a methadone maintenance program . Am J Forensic Med Pathol 1992; 13: 346-350 .

Clark JC , Milroy CM , Forrest ARWF. Deaths from methadone use . Journal of Clinical Forensic Medicine.

1,2 Potten, CS and Loeffler M 1990 (Development 110, 1001-1019)

Potten, CS , Booth C and Pritchard M Int. J. Exp. Path. 1997 78 219-243

Cai, W , Roberts, SA and Potten, CS. Int. J. Rad. Biol. 1997 71 573-579

Overturf, K. , Al-Dhalimy, M. , Ou, C-N. , Finegold, M. & Grompe, M. (1997) Am J. Path. 151, 1273-1280 .

Alison, M. R. , Golding, M. , Sarraf, C. E. , Edwards, R. J. & Lalani, E-N. (1996) Gastroenterology 110, 1182-1190 .

Alison, M. R. , Golding, M. & Sarraf, C. E. (1997) Int. J. Exp. Path. 78, 365-381 .

Simpson, M. G. , et al , (1996) Neurotoxicology, 17, 471-480 .

Widdowson, P. S. , et al (1996) Toxicol. Appl. Pharmacol. 136, 57-66 .

Lock, E. A. , et al , (1997) Toxicology 123, 41-51

Akazawa, C. , et al (1994) J. Comp. Neurol. 347, 150-160 .

Gibson, G. G. , Orton, T. C. , and Tanburini, P. P. (1982) Biochem J. 325:203, 161-168 .

Nelson, D. R. , Koymans, L. , Kamataki, T. , et al (1996) Pharmacogenetics 6, 1-42 .

Neng, Y. M. , Kuo, C-W. S. , Jones, P. S. , et al (1997) Biochem J. 325: 741-749 .

Kellerman, G. , Luyten-Kellerman, M. and Shaw, C. (1973) Amer. J. Hum. Genet. 25, 327-331 .

Kellerman, G. , Shaw, C. and Luyten-Kellerman, M. (1973) N. Engl. J. Med. 298, 934-937 .

Kouri, R. E. , McKinney, C. E. , Slomiany, D. J. , Snodgrass, D. R. , Wray, N. P. and McLemore, T. L. (1982) Cancer Res. 42, 5030-5037 .

Kawajiri, S. , Watanabe, J. , Eguchi, H. , Nakachi, K. , Kiyohara, C. and Hayashi, S. (1995) Pharmacogenetics. 5, 152-258 .

Jongen, W. F. M. & Dorgelo, F. O. (1986) Neth. J. Agric. Sci. 34: 395-404

Musonda, C. A. , Helsby, N. & Chipman, J. K. (1997) Hum. Exp. Toxicol. 16; 700-708

Chipman, J. K. , Davies, J. E. & Dash, P. (1995) Proc. B. P. S. 40: 193P-193P

Derby, L. E. , Hershel, J. , Henry, D. A. & Dean, A. D. (1993) Med. J. Aust. 158, 596-600 .

Maria, V. A. , Pinto, L. , & Victorino, R. M. M. (1994) J. Hepatol. 21, 151-158 .

Park, B. K. , Coleman, J. W. & Kitteringham, N. R. (1987) Biochem. Pharmacol. 36 (5), 581-590 .

Szymkowski, D. E. (1996) Drug Discov. Today 1, 415-428

Stein, C. A. & Cheung, Y-C. (1993) Science 261, 1004-1012

Sarmiento, U. , Perez, J. R. , Becker, J. M. & Narayanan, R. (1994) Antisense Res. & Dev. 4, 99-107

Enk, A. H. & Katz, S. I. (1992) Proc. Natl. Acad. Sci. USA 89, 1398-1402

Dearman, R. J. , Basketter, D. A. & Kimber, I (1996) Toxicol. Appl. Pharmacol. 138, 308-316 .

Robinson, M. K , Babcock, L. S. , Horn, P. A. and Kawabata, T. T. (1996) Fund. and Appl. Tox. 34, 15-24 .

Juniper, C. P. and Roberts, D. M. (1984) J. Soc. Occup Med. 34, 127-132 .

Robinson, M. K , Babcock, L. S. , Horn, P. A. and Kawabata, T. T. (1996) Fund. and Appl. Tox. 34, 15-24 .

Sarlo, K. , Fletcher, E. R. , Gaines, W. G. and Ritz, H. L. (1997) Fund. and Appl. Tox. 39, 44-52 .

Atkinson, H. A. C. and Miller, K. (1994) Toxicology, 91, 281-288 .

Atkinson, H. A. C. , Johnson, I. T. Gee, J. M. , Grigoriadou, F , and Miller, K. (1996). Fd. Chem. Toxicol. 34 (1) 27-32 .

Tang et al , (1996) Journal of Immunology, 157: 117-125

Dearman et al , (1997) Journal of Applied Toxicology, 17: 53-62

Toth, B. & Boreisha, I. (1969). Eur. J. Cancer, 5, 165-171 .

Schmahl, D. , Port, R. & Wahrendorf (1977). Int. J. Cancer 19, 77-85 .

Slaga, T. J. , Bowden, G. et al. (1974) Cancer Res. 34, 771-777 .

Ingram, A. & Grasso, P. (1977). Exp. Pathol. 14, 233-242 .

Schulte-Hermann, R. (1974). CRC Crit. Rev. Toxicol. 3, 97-197

Kaufmann, K. W. & Kaufman, D. G. (1993). FASEB 7, 1188-1191 .

IARC Monographs (1987) S7, 100-106

Hoag W. G. (1963) Ann. NY Acad. Sci. 108, 805-831

Myers, D. D. , Meier, H. & Huebner R. J. (1970) Life Sciences. 9(II), 1071-1080

Adkison D. L. & Sundberg J. P. (1991) Vet. Pathol. 28, 305-312

Ohtani, I. , Moore, R. E. and Runnegar, M. T. C. (1992) J. Am. Chem. Soc. 114, 7941-7942

Hawkins, P. R. , Runnegar, M. T. C. , Jackson, A. R. B. and Falconer, I. R. (1985) Appl. Environ. Microbiol. 50, 1292-1295

Seawright, A. A. , Nolan, C. C. , Shaw, G. R. , Chiswell, R. K. , et al. (1998). Environ. Toxicol. and Water Qual (in press).

Messina, M. J. , Persky, V. , Setchell, K. D. & Barnes, S. (1994) Nutr. Cancer 21, 113-131

Graichen, M. E. , Neptun, D. A. , Dent, J. G. , Popp, J. A. & Lennard, T. B. (1985). Fundament Appl. Toxicol., 5, 165-174 .

Lijinsky, W. , Reuber, M. D. & Blackwell, B.-N. (1980). Science, 209, 817-819 .

R. Caldwell & H. Challenger . Ann. of Clin. Biochem. 26: 430-443 (1989).

Substance Abuse and Mental Health Services Administration (1994) Federal Register 59 (110), 29903-29903

Rolfe, M. , James, N. H. and Roberts, R.A (1997) Tumour necrosis factor α (TNFα) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators ? Carcinogenesis 18, 2277-2280 .

Cohen S D & Khairallah E A (1997) Drug Met. Revs, 29 (1-2): 59-77

Roberts D W et al. (1991) Am J. of Pathol. 138 (2): 359-371

Shen, W (1991) Toxicol. Appl. Pharmacol. 111, 242-254

Ray, S. D. , Mumaw, V. R. , Raje, R. R. & Fariss, M. W. (1996) J. Pharmacol. Exp. Ther. 279, 1470-1483

Charlottle, F. , L'Hermine, A. , Martin, N. , Geleyn, Y. , Nollet, M. , Gaulard, P. & Zafrani, E. S. (1994) Am. J. Pathol. 144, 460-465

Skopelitou, A. , Hadjlyannakis, M. , Alexopoulou, V. , Krikoni, O. , Kamina, S. & Agnantis, N. (1996) Anticancer Res. 16, 975-978

Kaufmann, S. H. , Desnoyers, S. , Ottaviano, Y. , Davidson, N. E. & Poirer, G. G. (1993) Cancer Res 53, 3976-3985

Badger, G. A. , Kuester, R. K. , Sauer, J-M and Sipes, I. G. (1997) Toxicology 121, 143-153

Leatham, E. W. , Holt, D. W. and McKenna, W. J. (1993). Class III antiarrhtmics in overdose: Presenting features and management principles . Drug Safety, 9, 450-462 .

Hutchings, A. , Spragg, B. P. , and Routledge, P. A. (1986). High performance liquid chromatographic assay of amiodarone and desethyl amiodarone in plasma . Journal of Chromatography, 383, 389-393 .

Evans, D. A. P. (1996) J. med. Genet. 6, 405-407 .

Şardaş, S. , Karakaya, A. E. and Çok, I. (1986) Clin. Genet. 29, 185-186 .

Şardaş, S. , Pontin, J. and Idle, J. R. (1991) Pharmacogenetics 1, 123-124 .

Karakaya,A. E. , Çok,i. , Şardaş, S. , Gögüş, O and Şardaş, O. S. (1986) Human Toxicol. 5, 333-335 .

Şardaş, S. , Karakaya,A. E. and Şardaş,O. S. (1986) Arthiritis Rheum 29, 1412-1413 .

Şardaş, S. , Çok,I. , Şardaş,O. S. , Ilhan, O. and Karakaya,A. E. (1990) Int.J.Cancer 46, 1138-1139 .

Şardaş, S. , Akyol,D. , Green,R. L. , Mellon,T. , Gökmen,O. and Cholerton S. (1996) Pharmacogenetics 6, 459-463 .

Ashby J. et al. (1982) Mutat. Res. 93, 67-81 .

Ashby J. et al. (1985) Mutat. Res. 156, 1-18 .

Ashby J. unpublished data.

Brown E. V. & Sanchorawala C. J. (1968) J. Med. Chem. 11, 1074-1075 .

Elliott B. M. et al. (1983) Cancer Lett. 21, 69-76 .

Brinkschulte, M. , Gaertner, H. J. , Schied, H. W. & Breyer-Pfaff, H. (1982) Eur. J. Clin. Pharmacol. 22, 367-373

Pentel, R. P. & Benowitz, N. L. (1986) Medical Toxicology 1, 101-121

Kremer, J. M. , Wilting, J. & Janssen, L. H. (1988) Pharmacology Reviews 40, 1-47

van Luyn, M. J. A. , van Wachem, P. B. , Olde Damink, L. H. , Dijkstra, P. J. , Feijen, J. & Nieuwenhuis, P. (1991) J. Mater. Sci. 2, 142-148

Billi, B. , Lesnoni, G. , Scassa, C. , Giuliano, M. A. , Coppe, A. M. & Rossi, T. (1995) Eur. J. Ophthalmol. 5, 235-239

Virata, S. R. , Kylstra, J. A. & Pfeiffer, R. L. (1995) Ophthalmic Surg. 26, 142-144

Spooncer, E. , Boettiger, D. and Dexter, T. M. (1984) Nature 310 228-230 .

Liebmann, J. E. , Hahn, S. M. , Cook, J. A. , Lipschultz, C. , Mitchell, J. B. and Kaufman, D. C. (1993) Cancer Research 53(9) 2066-2070 .

Raucy, J. L. , Kraner, J. C. , and Lasker, J. M. (1993) Critical Reviews in Toxicology, 23, 1-20 .

Ferrara, R. , White, I. N. H. , and Manno, M. (1996) Toxicology Letters, Supplement 1/88, PID-156-PID-156

Wang, B. H. , Zuzel, K. A. , Rahman, K. & Billington,D. (1998) Toxicology (in press).

Azer, S. A. & Stacey, N. H. (1994) Toxiciol. Appl. Pharmacol. 124, 302-309 .

Boukamp,P. , Petrussevska,R. T. , Breitkreutz,D. , Hornung,J. , Markham,A. & Fusenig,N. E. (1988) J.Cell.Biol. 106. 761-771

de Morais, S. M. F. , Wilkinson, G. R. , Blaisdell, J. , Nakamura, K. , Meyer, U. A. & Goldstein, J. A. (1994) J. Biol. Chem. 269, 15419-15422

Andersson, T. , Miners, J. O. , Veronese, M. E. , Tassaneeyakul, W. , Meyer, U. A. & Birkett, D. J. (1993) Br. J. Clin. Pharmac. 36, 521-530

Hiramatsu, M. , Kumagai, Y. , Unger, S. E. , Cho, A. K. (1990) J. Pharmacol. Expt. Ther. 254, 521-527 .

Chu, T. , Kumagai, Y. , DiStefano, E. W. , Cho, A. K. (1996) Biochem. Pharmacol. 51, 789-796 .

McCann, U. D. & Ricaurte, G. A. (1991) Brain Res. 545, 279-282 .

Kumagai, Y. , Schmitz, D. A. , Cho, A. K. (1992) Xenobiotica 22, 395-403 .

Marrs, T. 1993 Pharmacol & Therapeutics 58 No 1 p 51-66

Johnson, M. K. 1982 Rev in Biochem Tox 4 p 141-212

Honnegger, P. & Richelson E. 1976 Brain Res 109 No7 p 335-354

Kingston, S. T. et al. 1997 Human & Exp. Tox. 16 No7 p 381-381

Friedman, H. , Shivers, S. C. & Klein, T. W. (1994). In Immunotoxicology and Immunopharmacology eds. Dean, J. H. , Luster, M. I. , Munson, A. E. & Kimber, I pp. 303-322. New York: Raven Press

Schwarz, H. , Blanco, F. J. & Lotz M. (1994) Journal of Neuroimmunology 55, 107-115

Jeon, Y. J. , Yang, K. H. , Pulaski, J. T. , & Kaminski, N. E. (1996) Molecular Pharmacology 50, 334-341

Simpson, MG. , Wyatt, I. , Jones, HB. , Gyte, AJ. , Widdowson, PS. and Lock, EA (1996) Neurotoxicology, 17, 471-480 .

Wyatt, I. , Farnworth, M. , Gyte, AJ. and Lock, EA. (1997) Arch Toxicol. 71, 668-676 .

Sedlak,J and Lindsay, RH. (1968) Anal. Biochem. 25, 192-205 .

Wyatt, I. , Gyte, AJ. , Mainwaring, G. , Widdowson, PS. and Lock EA (1996) Arch Toxicol. 70, 380-389 .

Simpson, M. G. , Wyatt, I. , Jones, H. B. , Gyte, A. J. , Widdowson, P. S. & Lock, E. A. (1996) Neurotoxicology. 17, 471-480 .

Widdowson, P. S. Wyatt, I. , Gyte, A. , Simpson, M. G. & Lock, E. A. (1996) Toxicol. & Appl. Pharmacol. 136, 138-145 .

Sturgess, N. C. , Wilkinson, E. L. & Lock, E. A. (1997) Hum. & Exp. Toxicol. 16, 383-383 .

Cheng, B. and Mattson, M. P. (1991) Neuron 7, 1031-1041 .

Mattson, M. P. , Kumar, K. N. , Wang, H. , Cheng, B. and Michaelis, E. K. (1993) J. Neurosci. 13, 4575-4588 .

Houle, J. D. and Ye, J. H. (1997) Neurorport 8(3), 751-755 .

Chambeerlain, M. P. , Lock, E. A. , Rimmel, B. A. & Reed, C. J. (1998) Arch. Toxicol. (in press)

Sturgess, N. C. , Wilkinson, E. L. & Lock, E. A. (1997) Hum. Exp. Toxicol. 16: 383-383 .

Rosenberg, L. , et al. , (1991) J. Natl. Cancer Inst. 83, 355-358 .

Boolbol, S. K. , et al. , (1996) Cancer Res. 56, 2556-2560 .

Wallace, H. M. & Walker, L. (1997) Eur. J. Clin. Pharmacol. 52, Suppl. A111-A111

Seglen P. O. (1976)Methods Cell Biol 13, 29-83

Juillerta, M et al (1997) Toxicology In Vitro 11, 57-693

Hamilton, G. et al (1995) Human and Experimental Toxicology 15, 153-153

Munday, R. (1992) Chem. Biol. Inter. 82: 165-219 .

Blair, J. A. , Waterfield, C. W. , Lightfoot, R. M. , York, M. and Turton, J. A. (1997) Hum. Exp. Tox. 16: 403-403 .

Lapre, J. A. & Van der Meer, R. (1992)Carcinogenesis 13, 41-44

Rafter, J. J. , Child, P. , Anderson, A. M. , Alder, R. , Eng, V. & Bruce, B. R. (1987) Am.J.Clin.Nutr. 45, 559-563

Rafter, J. J. , & Branting, C. (1991) Eur.J.Cancer Prev. 1, 49-54

Armstrong, B. & Doll, R. (1975) Int.J.Cancer 15, 617-631

Venturi, M. , Hambly, R. J. , Glinghammar, B. , Rafter, J. J. & Rawland, I. R. (1997) Carcinogenesis 18, 2353-2359

Pinto, M. , Robine-Leon, S. , Appay, M. et al. (1983) Biol. Cell. 47, 323-330 .

Peterson, M. D. & Mooseker M. S. (1993) J.Cell Science. 105, 445-460 .

Martin, F. L. , Carmichael, P. L. , Crofton-Sleigh, C. , Venitt, S. , Phillips, D. H. & Grover, P. L. (1996)Cancer Res. 56, 5342-5346 .

Martin, F. L. , Venitt, S. , Carmichael, P. L. , Crofton-Sleigh, C. , Stone, E. M. , Cole, K. J. , Gusterson, B. A. , Grover, P. L. & Phillips, D. H. (1997) Carcinogenesis 18, 2299-2305 .

Henderson, B. E. , Ross, R. K. and Pike, M. C. (1993) Science 259: 633-638 .

Kuiper, G. G. J. M. , Enmark, E. , Pelto-Huikko, M. , Nilsson, S and Gustafsson, J.-A. (1996) Proc. Natl. Acad. Sci. USA 93: 5925-5930 .

Mocarelli, P. (1997) Dioxin '97. 17th International Symposium on Chlorinated Dioxins and Related Compounds. Indianapolis, Indiana, USA, & Personal Communication.

Lewis, D. F. V. (1996) Cytochromes P450 Structure, Function and Mechanism. Taylor & Francis, London .

Gibson, G. G. & Skett, P. (1994) Introduction to Drug Metabolism. Chapman & Hall, London .

Bertazzi, P. A. & di Domenico, A. (1994) In Dioxins and Health ed. Arnold Schecter . Plenum Press, New York . pp 587-632

Bertazzi, P. A. , Zochetti, C. , Guercilena, S. , Consonni, D. , Tironi, A. , Landi, M. , & Pesatori, A. C. (1997) Epidemiology Vol 8., No. 6. pp 646-652

Lewis, D. F. V. & Lee-Robichaud, P. (1998) J. Steroid Biochem. Molec. Biol., IN press

Salzman, A. L. (1995) New Horiz. 3(2), 352-364

Simon, L. , Warren, I. & Dayan, A. D. (1997) Dig. Dis. Sci. 42(7), 1519-1523

Mellstrom, B. , Alvan, G. , Bertilsson, L. , Potter, W. Z. , Sawe, J. & Sjoqvist, F. (1982) Clin. Pharmacol. Ther. 32, 664-667 .

Olesen, O. V. & Linnet, K. Drug Met. Disp. (1997) 25, 740-744 .

Crewe, H. K. , Lennard, M. S. , Tucker, G. T. , Woods, F. R. & Haddock, R. E. Br. J. Clin. Pharmacol. (1992) 34, 262-265 .

Schulz, P. , Dick, P. , Blascke, T. F. & Hollister, L. Clin. Pharmacokinet. (1985) 10, 257-268 .

Ghahramani, P. , Davies, S. J. C. , Yeo, W. W. , Jackson, P. R. , Lennard, M. S. , Tucker, G. T. & Ramsay, L. E. Br. J. Clin. Pharmacol. (1998) In press.

Felton, J. S. , Kinze, M. G. , Shen, N. H. , Andersen, B. D. , Djeldanes, L. F. and Hatch, F. T. (1986) Environ. Health Perspec. 67, 17-24 .

Lin, D. , Kaderlik, K. R. , Turesky, R. J. , Miller, D. W. , Lay, Jr, J. O. and Kadlubar, F. F. (1992) Chem. Res. Toxicol. 5, 691-697 .

Crosbie, S. J. , Gooderham, N. J. , Murray, S. , Taylor, G. W. and Boobis, A. R. (1997) Hum, & Exp. Toxicol., 16, 59-59 .

Frandsen, H. (1997) Carcinogenesis, 18, 1555-1560 .

Zhao, K. , Murray, S. , Davies, D. S. , Boobis, A. R. and Gooderham, N. J. (1994) Carcinogenesis, 15, 1285-1288 .

Frandsen, H ,, Grivas, S. , Andersson, R. , Dragsted, L. , Larsen, J. C. (1992) Carcinogenesis, 13, 629-635 .

Warner, A. E. (1996) Clinics in Chest Medicine. 17(1): 125-135 .

Hawton, K. , Ware, C. , Mistry, H. , Hewitt, J. , Kingsbury, S. , Roberts, D. , and Weitzel, H. (1995). Why patients choose paracetamol for self-poisoning and their knowledge of its dangers . British Medical Journal, 310, 164-164

Hawton, K. , Ware, C. , Mistry, H. , Hewitt, J. , Kingsbury, S. , Roberts, D. , and Weitzel, H. (1996). Paracetamol self-poisoning, characteristics, prevention and harm reduction . British Journal of Psychiatry, 168, 43-48

Smith, A. G. , Clothier, B. , Robinson, S. , Scullion, M. J. , Carthew, P. , Edwards, R. , Luo, J. L. , Lim, C. K. & Toledano, M (1998) Molec. Pharmacol. 153, 52-61 .

Sinclair, P. , Gorman, N. , Dalton, T. , Walton, H. S. , Bement, W. J. , Sinclair, J. F. , Smith, A. G. , Nebert, D. W. (1998) Biochem. J. 329, 149-153 .

Lui, J. , Lui, Y. , Barter, R. A. & Klaassen, C. D. (1995) J. Pharmacol. Exp. Ther. 273 (2), 977-985

Ikushiro, S. , Emi, Y. & Iyanagi, T. (1995) Arch. Biochem. Biophys. 324 (2), 267-272

Hippeli, S & Elstner, E. F. (1997) Z. Naturforsch. 52c, 555-563 .

Reed, C. J. (1993) Drug Metab Rev. 25, 173-206 .

Young, J. (1981) Fund Appl Toxicol. 1, 309-312 .

Kilgour, J. D et al. (1998) Toxicol Met (In Press).

Sai, K. , Takagi, A. , Urnemura, T. , Hasegawa, R. & Kurokawa Y. (1991) Jpn. J. Cancer. Res. 82, 165-169

Floyd, R. A. , Watson, J. J. , Wong, P. K. , Altmiller, D. H. & Rickard, R. C. (1986) Free Rad. Res. Commun. 1, 163-172

Singh, N. P. , McCoy, M. T. , Tice, R. R. & Schneider, E. L. (1988) Exp. Cell Res. 175, 184-191

J. A. Timbrell , V. Seabra and C. J. Waterfield (1995), Gen. Pharmac. 26: 453-462 .

C. S. Lieber and L. M. De Carli . (1989), Alcohol and Alcoholism 24: 197-211 .

J. Chem and G. C. Farrell . (1996), J. Gastroenterol. Hepatol. 11: 870-877 .

Control of Pesticides Regulations 1986 (COPR) (SI 1986/1510). ISBN 0-11-067510-X

Plant Protection Products Regulations 1995 (PPP) (SI 1995/887). ISBN 0-11-052865-4

The Registration Handbook - available from Pesticides Safety Directorate

United States Environmental Protection Agency (1993). Pesticide Reregistration Rejection Rate Analysis. EPA783-R-93-004

Van den Heuvel M. J , Clark D. G. , Fielder R. J , Koundakjian P. P , Oliver G. J. A , Pelling D , Tomlinson N. J and Walker A.P (1990). The international validation of a fixed dose procedure as an alternative to the classical LD50 test . Food Chem. Tox., 28, 469-482 .

Ireland,J. S. , Mukku, V. R. , Robison,A. K. & Stance, G. M. (1980) Biochem. Pharmacol. 29, 1469-1474

Routledge,E. J. & Sumpter,J. P. (1996) Environ.Toxicol.Chem. 15, 241-248

Messina, M. J. , Persky, V. , Setchell, K. D. & Barnes, S. (1994) Nutr. Cancer 21, 113-131 .

Moser, A. R. , Luongo, C. , Gould, K. A. , McNeley, M. K. , Shoemaker, A. R. & Dove, W. F. (1995) Eur. J. Cancer 31A, 1061-1064 .

Cassidy, A (1996) Proceedings of the Nutrition Society 55, 399-412

Ruíz-Ramírez L , Gracia-Mora I , Moreno-Esparza R , Díaz D , Gasque L , Huerta L , Mayet L , Ortiz V and Lomeli C (1991) J. Inorganic Biochemistry 43: 615-615 .

DeVizcaya-Ruiz A , Ruíz-Ramírez L , Kelland LR , Orr RM and Dobrotta M (1998) 89th Annual Meeting of the American Association for Cancer Research. New Orleans, Louisiana, USA.

Huber KR , Sridhar R , Griffith EH , Amma EL and Roberts J (1987) Biochimica Biophysica Acta 915: 267-276 .

Von Sonntag C. The chemical basis of radiation biology, Taylor and Francis, London , 1987.

Ruiz-Ramirez, L et al. (1995) J Inorg Biochem 59: 207-207 .

Aaseth J , and Norseth T Copper . Handbook on the Toxicology of Metals, 2nd ed. Friberg L , Nordberg GF , and Vouk V (1986) ed. Elsiever : pp233-248.

Chukhlovin, A. B. , Tokalov, S. V. , Yagunov, A. S. & Zharskaya, v. D. (1996) Trace Elem and Electrol 13: 37-41 .

Evans, G. W. & Wiederanders, R. E. (1967) Am J Physiol 213: 1183-1185 .

Scheinberg, I. H. et al. (1987) N Engl J Med, 317: 209-213 .

Jones MM , Basinger MA & Tarka MP (1980) Res Comm Chem Pathol Parmacol 27: 571-577

Deray G and Jacobs C (1995) Radiocontrast nephrotoxicity, a review . Invest Radiol 30: 221-225

Morcos SK , Epstein FH , Haylor J , Dobrota M (1996) Aspects of contrast media nephrotoxicity . Eur J Radiol 23: 178-184 .

Kerr, J. F. R. , Wyllie, A. H. , Currie, A. R. (1972). Br J Cancer, 26, 239-257 .

Rudin C. M. & Thompson C. B. (1997) Annu. Rev. Mod. 48, 267-281 .

Ogasawara J. , Watanabe-Fukunaga R. , Adachi M. , Matsuzawa A. , Kasugai T. , Kitamura Y. , et al (1993) Nature, 364, 806-809 .

Nagata S. (1997) Cell, 88, 355-365 .

Minchin, R. F. (1995) Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human N-acetyltransferase and U937 cells . Biochem. J. 307, 1-3 .

Stanley, L. A. , Mills I. G. & Sim, E. (1997) Localisation of polymorphic N-acetyltransferase (NAT2) in tissues of inbred mice . Pharmacogenetics 7, 121-130 .

Murray, G. I. , Taylor, M. C. , McFadyen, M. C. E. , McKay, J. A. , Greenlee, W. F. , Burke, M. D. & Melvin, W. T. (1997) Tumour-specific expression of cytochrome P450 CYP1B1 . Cancer Res. 57, 3026-3031 .