Acute and chronic human toxicity of theophylline

Levine JH , Michael JR , Guarnieri T. Multifocal atrial tachycardia: A toxic effect of theophylline. Lancet 1985; 1: 12-14.

Woodcock AA , Johnson MA , Geddes DM Theophylline prescribing, serum concentrations, and toxicity. Lancet 1983; 2: 610-613.

Greening AP , Baillie E. , Pride NB Sustained release oral aminophylline in patients with airflow obstruction . Thorax 1981; 36: 303-307.

Aronson JK , Hardman M. , Reynolds Djm. ABC of monitoring drug therapy. Theophylline. British Medical Journal 1992; 305: 1355 -1358.

Bukowskyj M. , Nakatsku K. , Munt PW Theophylline reassessed. Annals of Internal Medicine 1984; 101: 63 - 73.

Hendeles L. , Weinberger M. Theophylline: a 'state of the art' review. Pharmacotherapy 1983; 3: 2-44.

Jacobs MH , Senior RM , Kessler G. Clinical experience with theophylline. Relationships between dosage, serum concentration and toxicity. Journal of the American Medical Association 1976; 235: 1983-1986.

Jenne JW , Wyze E. , Rood FS , MacDonald FM Pharmacokinetics of theophylline. Applications to adjustment of the clinical dose of aminophylline. Clinical Pharmacology and Therapeutics 1972; 13: 349-360.

Josephson GW , Kennedy HL , MacKenzie EJ , Gibson G. Cardiac dysrhythmias during treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol . Chest 1980; 78: 429-435.

Ogilvie RI , Fernandez PG , Winsberg F. Cardiovascular response to increasing theophylline concentrations. European Journal of Clinical Pharmacology 1977; 2: 409-414.

Zandvoort FA et al. Theophylline and serum electrolytes. Annals of Internal Medicine 1986; 104: 134-135.

Hendeles L. , Jenkins J. , Temple R. Revised FDA labeling guidelines for theophylline oral dosage forms. Pharmacotherapy 1995; 15: 409-426.

Burgan Ths , Gupta I. , Bate CM Fatal overdose of theophylline simulating acute pancreatitis. British Medical Journal 1982; 284: 939-940.

Eason J. , Markowe Hlj. Aminophylline toxicity- how many hospital deaths does it cause? Respiratory Medicine 1989; 83: 219-226.

Henderson A. , Wright DM , Pond SM Management of theophylline overdose patients in the Intensive Care Unit. Anaesthesia and Intensive Care 1992; 20: 56-62.

Gaudreault P. , Guay J. Theophylline poisoning. Pharmacological considerations and management. Medical Toxicology 1986; 1: 169-191.

Helliwell M. , Berry D. Theophylline poisoning in adults. British Medical Journal 1979; 2: 1114.

Jefferys DB et al. Haemoperfusion for theophylline overdose . British Medical Journal 1980; 280: 1167.

Robertson NJ Fatal overdose from a sustained-release theophylline preparation. Annals of Emergency Medicine 1985; 14: 154-158.

Zwillich CW et al. Theophylline-induced seizures in adults. Correlation with serum concentrations. Annals of Internal Medicine 1975; 82: 784-787.

Higgins RM et al. Severe theophylline poisoning: charcoal haemoperfusion or haemodialysis ? Postgraduate Medical Journal 1995; 71: 224-226.

Hendeles L. , Massanari M. , Weinberger M. Update on the pharmacodynamics and pharmacokinetics of theophylline. Chest 1985; 88: (suppl) 103S-111S.

Sessler CN Theophylline toxicity: clinical features of 116 consecutive cases. American Journal of Medicine 1990; 88: 567-576.

Weinberger M. The pharmacology and therapeutic use of theophylline . Journal of Allergy and Clinical Immunology 1984; 73: 525-540.

Mitenko PA , Ogilvie RI Rational intravenous doses of theophylline. New England Journal of Medicine 1973; 289: 600-603.

Hendeles L. , Weinberger MM , Bighley L. Disposition of theophylline following a single intravenous infusion of aminophylline. American Review of Respiratory Disease 1978; 118: 97-103.

Hendeles L. , Weinberger M. Avoidance of adverse effects during chronic therapy with theophylline. European Journal of Respiratory Disease 1980; 61: (suppl 109) 103-119.

Milavetz G. , Vaughan LM , Weinberger MM , Hendeles L. Evaluation of a scheme for establishing and maintaining dosage of theophylline in ambulatory patients with chronic asthma . Journal of Pediatrics 1986; 109: 351-354.

Weinberger M. , Hendeles SL Slow-release theophylline: Rationale and basis for product selection. New England Journal of Medicine 1983; 308: 760-764.

Brodie MJ , Hallworth MJ Therapeutic monitoring of theophylline. Hospital Update 1988; 14: 1208-1221.

Tsai J. et al. The clinical implication of theophylline intoxication in the emergency department. Human and Experimental Toxicology 1994; 13: 651-657.

Paloucek FP , Rodvold KA Evaluation of theophylline overdoses and toxicities . Annals of Emergency Medicine 1988; 17: 135-144.

Frewin DB , Cooper DJ Accidental coadministration of intravenous aminophylline and theophylline by mouth: a hazardous practice. Medical Journal of Australia 1986; 144: 481-482.

Schiff CD , Hegde HK , LaCloche L. , Hryhorczuk DO Inpatient theophylline toxicity: preventable factors. Annals of Internal Medicine 1991; 114: 748-753.

Johnston Ida. Controversies in therapeutics: theophylline in the management of airflow obstruction. 2. Difficult drugs to use, few clinical indications. British Medical Journal 1990; 300: 929-931.

Munro CS , Prowse K. Doses of aminophylline given intravenously in casualty department and resulting serum theophylline concentrations. British Medical Journal 1984; 289: 354-355.

Stewart MF , Barclay J. , Warburton R. Risk of giving intravenous aminophylline to acutely ill patients receiving maintenance treatment with theophylline. British Medical Journal 1984; 288: 450.

Howell RE , Muehsam WT , Kinnier WJ Mechanism for the emetic side effect of xanthine bronchodilators. Life Sciences 1990; 46: 563-568.

Gaudreault P. , Wason S. , Lovejoy Jr FH Acute pediatric theophylline overdose: a summary of 28 cases. Journal of Pediatrics 1983; 102: 474-476.

Sessler CN , Glauser FL , Cooper KR Treatment of theophylline toxicity with oral activated charcoal. Chest 1985; 87: 325-329.

Andersson KE , Persson Cga. Extrapulmonary effects of theophylline. European Journal of Respiratory Disease 1980; 61: (suppl 109) 17-28.

Foster LJ , Trudeau WL , Goldman AL Bronchodilator effects on gastric acid secretion. Journal of the American Medical Association 1979; 241: 2613-2615.

Johannesson N. , Anderson K-E., Joelsson B. , Persson Cga. Relaxation of lower esophageal sphincter and stimulation of gastric secretion and diuresis by antiasthmatic xanthines . American Review of Respiratory Disease 1985 ; 131: 26-31.

Amitai Y. , Yeung AC , Moye J. , Lovejoy FH Jr. Repetitive oral activated charcoal and control of emesis in severe theophylline toxicity. Annals of Internal Medicine 1986; 105: 386-387.

Amitai Y. , Lovejoy FH Jr. Characteristics of vomiting associated with sustained release theophylline poisoning: implications for management with oral activated charcoal. Clinical Toxicology 1987; 25: 539-544.

Anderson W. , Youl B. , Mackay IR Acute theophylline intoxication. Annals of Emergency Medicine 1991; 20: 1143-1145.

Parr MJ et al. Theophylline poisoning - a review of 64 cases. Intensive Care Medicine 1990; 16: 394-398.

Vaucher Y. , Lightner ES , Walson PD Theophylline poisoning. Journal of Pediatrics 1977; 90: 827-830.

Olson KR , Benowitz NL , Woo OF , Pond SM Theophylline overdose: acute single ingestion versus chronic repeated over-medication . American Journal of Emergency Medicine 1985 ; 3: 386-394.

Amitai Y. , Mitchell AA , McGuigan MA , Lovejoy FH Jr. Ipecac-induced emesis and reduction of plasma concentrations of drugs following accidental overdose in children. Pediatrics 1987; 80: 364-367.

Powell DW , Farris RK , Carbinetto ST Theophylline, cyclic AMP, choleragen and electrolyte transport by rabbit ileum . American Journal of Physiology 1974; 227: 1428-1435.

Baker MD Theophylline toxicity in children. Journal of Pediatrics 1986; 109: 538-542.

Aitken ML , Martin TR Life-threatening theophylline toxicity is not predictable by serum levels . Chest 1987; 91: 10-14.

Hall KW et al. Metabolic abnormalities associated with intentional theophylline overdose. Annals of Internal Medicine 1984 ; 101: 457-462.

Sessler CN , Cohen MD Cardiac arrhythmias during theophylline toxicity. A prospective continuous electrocardiographic study. Chest 1990; 98: 672-678.

Siemons LJ , Parizel G. Prolonged runs of ventricular tachycardia as a complication of theophylline intoxication. Acta Cardiologica 1986; 6: 457-464.

Hoford N. et al. Theophylline target concentration in severe airways obstruction - 10 or 20 mg/L? Clinical Pharmacokinetics 1993; 25: 495-505.

Hendeles L. et al. Frequent toxicity from i.v. aminophylline infusions in critically ill patients. Drug Intelligence and Clinical Pharmacy 1977; 2: 12-18.

Horowitz LN , Spear JF , Moore EN , Rogers R. Effects of aminophylline on the threshold for initiating ventricular fibrillation during respiratory failure. American Journal of Cardiology 1975; 35: 376-379.

Biberstein MP , Fiegler MG , Ward DM Use of β-blockade and hemoperfusion for acute theophylline poisoning. Western Journal of Medicine 1984; 141: 485-490.

Curry SC , Vance MV , Requa R. , Armstead R. The effects of toxic concentrations of theophylline on oxygen consumption, ventricular work, acid base balance and plasma catecholamine levels in the dog. Annals of Emergency Medicine 1985; 14: 554-561.

Higbee MD , Kumar M. , Galant SP Stimulation of endogenous catecholamine release by theophylline: a proposed additional mechanism of action for theophylline effects. Journal of Allergy and Clinical Immunology 1982; 70: 377-382.

Vestal RE et al. Effect of intravenous aminophylline on plasma levels of catecholamines and related cardiovascular and metabolic responses in man. Circulation 1983; 67: 162-171.

Rutherford JD , Vatner SF , Braunwald E. Effects and mechanism of action of aminophylline on cardiac function and regional blood flow distribution in conscious dogs . Circulation 1981; 63: 378-387.

Roden DM , Iansmith Dhs. Effects of low potassium or magnesium concentrations on isolated cardiac muscle . American Journal of Medicine 1987; 82: (suppl 3A) 18-23.

Nordrehaug JE , Johannesson K-A. , von der Lippe G. Serum potassium concentrations as a risk factor of ventricular arrhythmias early in acute MI. Circulation 1985; 71: 645-649.

Stewart DE , Ikram H. , Espiner EA , Nichols MG Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertensive and ischaemic heart disease. British Heart Journal 1985; 54: 290-297.

Lim R. , Walshaw MJ , Saltissi S. , Hind Crk. Cardiac arrhythmias during acute exacerbations of chronic airflow limitation: effect of fall in plasma potassium concentration induced by beta2-agonist therapy. Postgraduate Medical Journal 1989 ; 65: 449-452.

Persson CG , Erjefalt L. Seizure activity in animals given enprofylline and theophylline, two xanthines with partly different mechanisms of action. Archives Internationales de Pharmacodynamie et de Therapie 1982; 258: 267-282.

Somani SM , Khanna NN , Bada HS Caffeine and theophylline: serum/CSF correlation in premature infants. Journal of Pediatrics 1980; 96: 1091-1093.

Jensen MH et al. Is theophylline induced seizures in man caused by inhibition of cerebral 5'nucleotidase activity? Acta Pharmacologica et Toxicologica 1984; 55: 331-334.

Dragunow M. Adenosine receptor antagonism accounts for the seizure prolonging effects of aminophylline. Pharmacology, Biochemistry and Behavior 1990; 36: 751-755.

Hornfeldt CS , Larson AA Adenosine receptors are not involved in theophylline-induced seizures. Clinical Toxicology 1994; 32: 257-265.

Edvinsson L. , Fredholm BB Characteristics of adenosine receptors in isolated cerebral arteries of cat. British Journal of Pharmacology 1983; 80: 631-637.

Oberdorster G. , Lang R. , Zimmer R. Influence of adenosine and lowered cerebral blood flow on the cerebrovascular effects of theophylline. European Journal of Pharmacology 1975; 30: 197-204.

Burkle WS , Gwizdala CJ Evaluation of 'toxic' serum theophylline concentrations. American Journal of Hospital Pharmacy 1981; 38: 1164-1166.

Covelli HD , Knodel AR , Heppner BT Predisposing factors to apparent theophylline-induced seizures. Annals of Allergy 1985; 54: 411-415.

Bahls FH , Ma KK , Bird TD Theophylline-associated seizures with 'therapeutic' or low toxic serum concentrations: Risk factors for serious outcome in adults. Neurology 1991; 41: 1309-1312.

Emerman CL , Devlin C. , Connors AF Risk of toxicity in patients with elevated theophylline levels. Annals of Emergency Medicine 1990; 19: 643-648.

D'Angio R. , Sabatelli F. Management considerations in treating metabolic abnormalities associated with theophylline overdose. Archives of Internal Medicine 1987; 147: 1837-1838.

Kearney TE , Manoguerra AS , Curtis GP , Ziegler MG Theophylline toxicity and the beta-adrenergic system. Annals of Internal Medicine 1985; 102: 766-769.

Sawyer WT , Caravati EM , Ellison MJ , Krueger KA Hypokalemia, hyperglycemia and acidosis after intentional theophylline overdose . American Journal of Emergency Medicine 1985 ; 3: 408-411.

Church MK et al. Relationships between adenosine, cyclic nucleotides, and xanthines in asthma. Journal of Allergy and Clinical Immunology 1986; 78: 670-675.

Poisner AM Direct stimulant effect of aminophylline on catecholamine release from the adrenal medulla. Biochemical Pharmacology 1973; 22: 469-476.

Stubbs A. , Cushley MJ , Tattersfield AE Attenuation by propranolol of the airway and cardiovascular responses to oral theophylline in normal subjects. Clinical Science 1984; 66: 57P.

Brown MJ Hypokalaemia from beta2-receptor stimulation by circulating epinephrine. American Journal of Cardiology 1985; 56: 3D-9D.

Brown MJ , Brown DC , Murphy MB Hypokalaemia from beta2-receptor stimulation by circulating epinephrine. New England Journal of Medicine 1983; 309: 1414-1419.

Clausen T. Adrenergic control of Na+-K+-homeostasis. Acta Medica Scandinavica 1983; 672: (suppl) 111-115.

Clausen T. , Flatman JA β2-adrenoceptors mediate the stimulating effect of adrenaline on active electrogenic Na-K-transport in rat soleus muscle. British Journal of Pharmacology 1980; 68: 749-755.

Struthers AD , Reid JL , Whitesmith R. , Rodger JC The effects of cardioselective and non-selective β-adrenoceptor blockade on the hypokalaemic and cardiovascular response to adrenomedullary hormones in man. Clinical Science 1983; 65: 143-147.

Shannon M. , Lovejoy FH Jr. Hypokalemia after theophylline intoxication. The effects of acute vs chronic intoxication. Archives of Internal Medicine 1989; 149: 2725-2729.

Shannon M. Hypokalemia, hyperglycemia and plasma catecholamine activity after severe theophylline intoxication. Clinical Toxicology 1994; 32: 41-47.

Amitai Y. , Lovejoy FH Jr. Hypokalaemia in acute theophylline poisoning. American Journal of Emergency Medicine 1988; 6: 214-218.

Strubelt O. The influence of reserpine, propranolol and adrenal medullectomy on the hyperglycaemia action of theophylline and caffeine . Archives Internationales de Pharmacodynamie et de Therapie 1969; 179: 214-224.

Rasmussen HS et al. Intravenous magnesium in acute myocardial infarction. Lancet 1986; 1: 234-235.

Smith LF et al. Intravenous infusion of magnesium sulphate after acute myocardial infarction: effects on arrhythmias and mortality. International Journal of Cardiology 1986; 12: 175-183.

Teo KK , Yusuf S. Role of magnesium in reducing mortality in acute myocardial infarction. Drugs 1993; 46: 347-359.

Chevalier B. et al. Tachycardie ventriculaire au cours d'un surdosage en theophylline. A propos d'un cas de reduction par le chlorure de magnesium. Archives des Maladies du Coeur et des vaisseaux 1990; 83: 569-573.

McPherson ML et al. Theophylline-induced hypercalcemia. Annals of Internal Medicine 1986; 105: 52-54.

Bernard S. Severe lactic acidosis following theophylline overdose. Annals of Emergency Medicine 1991 ; 20: 1135-1137.

Leventhal LJ et al. Lactic acidosis in theophylline overdose . American Journal of Emergency Medicine 1989 ; 7: 417-418.

Kolendorf K. , Moller BB Lactic acidosis in epinephrine poisoning. Acta Medica Scandinavica 1974; 196: 465-466.

Madias NE , Goorno WE , Herson S. Severe lactic acidosis as a presenting feature of phaeochromocytoma. American Journal of Kidney Disease 1987; 10: 250-253.

Bornemann M. , Hill SC , Kidd GS Lactic acidosis in phaeochromocytoma. Annals of Internal Medicine 1986; 105: 880-882.

Spergel G. , Bleicher SJ , Ertel NH Carbohydrate and fat metabolism in patients with phaeochromocytoma. New England Journal of Medicine 1968; 278: 803-809.

Eldridge FL , Millhorn DE , Kiley JP Antagonism by theophylline of respiratory inhibition induced by adenosine. Journal of Applied Physiology 1985; 59: 1428-1433.

Oliw E. , Anggard E. , Fredholm BB Effect of indomethacin on the renal actions of theophylline. European Journal of Pharmacology 1977; 43: 9-16.

Rumpf KW et al. Rhabdomyolysis after theophylline overdose. Lancet 1985; 1: 1451-1452.

Modi KB , Horn EH , Bryson SM Theophylline poisoning and rhabdomyolysis. Lancet 1985; 2: 160-161.

Parr MJ , Willatts SM Fatal theophylline poisoning with rhabdomyolysis. A potential role for dantrolene treatment. Anaesthesia 1991; 46: 557-559.

Macdonald JB , Jones HM , Cowan RA Rhabdomyolysis and acute renal failure after theophylline overdose. Lancet 1985; i: 932-933.

Koppel C. Clinical features, pathogenesis and management of drug-induced rhabdomyolysis . Medical Toxicology and Adverse Drug Experience 1989; 4: 108-126.

Shannon M. Predictors of major toxicity after theophylline overdose. Annals of Internal Medicine 1993 ; 119: 1161-1167.

Grygiel JJ , Wing Lmh , Farkas J. , Birkett DJ Effect of allopurinol on theophylline metabolism and clearance. Clinical Pharmacology and Therapeutics 1979; 36: 660-667.

Campbell ME , Grant DM , Inaba T. , Kalow W. Biotransformation of caffeine, paraxanthine, theophylline and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome P450 in human liver microsomes. Drug Metabolism and Disposition 1987; 15: 237-249.

Robson RA et al. Characterization of theophylline metabolism in human liver microsomes . British Journal of Clinical Pharmacology 1987; 24: 293-300.

Robson RA et al. Characterisation of theophylline metabolism by human liver microsomes . Biochemical Pharmacology 1988; 37: 1651-1659.

Sarkar MA , Hunt C. , Guzelian PS , Karnes T. Characterization of human liver cytochromes P-450 involved in theophylline metabolism. Drug Metabolism and Disposition 1992; 20: 31-37.

Rall TW Drugs used in the treatment of asthma. The methylxanthines, cromolyn sodium and other agents. In: Goodman and Gilman's The Pharmacological Basis of Therapeutics Gilman AG , Rall TW , Nies AS , Taylor P (eds), 8th edition, McGraw-Hill Inc, 1992; 618-637.

Aranda JV , Turmen T. Methylxanthines in apnea of prematurity. Clin Perinatol 1979; 6: 87-108.

Ha HR , Chen J. , Freiburghaus AU , Follath F. Metabolism of theophylline by cDNA-expressed human cytochromes P-450. British Journal of Clinical Pharmacology 1995; 39: 321-326.

Tucker GT The rational selection of drug interaction studies: implications of recent advances in drug metabolism. International Journal of Clinical Pharmacology Therapeutics and Toxicology 1992; 30: 550-553.

Hurwitz A. et al. Mexiletine effects on theophylline disposition . Clinical Pharmacology and Therapeutics 1991 ; 50: 299-307.

Knodell RG et al. Differential inhibition of individual human liver cytochromes P-450 by cimetidine. Gastroenterology 1991; 101: 1680-1691.

Grygiel JJ , Miners JO , Drew R. , Birkett DJ Differential effects of cimetidine on theophylline metabolic pathways. European Journal of Clinical Pharmacology 1984; 26: 335-340.

Loi CM , Wei X. , Vestal RE Inhibition of theophylline metabolism by mexiletine in young male and female nonsmokers. Clinical Pharmacology and Therapeutics 1991; 49: 571-580.

Miners JO , Wing Lmh , Lillywhite KJ , Robson RA Selective dose-dependency of the inhibitory effect of propranolol on theophylline metabolism in man. British Journal of Clinical Pharmacology 1985; 20: 219-223.

Loi CM , Parker BM , Cusack BJ , Vestal RE Individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism in male nonsmokers. British Journal of Clinical Pharmacology 1993; 36: 195-200.

Conney AH Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: GHA Clowes memorial lecture. Cancer Research 1982; 42: 4875-4917.

Shimada T. , Iwasawi M. , Martin MV , Guengerich FP Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. Cancer Research 1989; 49: 3218-3228.

Rubin E. , Lieber CS Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol . Science 1969; 169: 690-691.

Wrighton SA et al. Characterization of ethanol inducible human liver N-nitrosodimethylamine demethylase. Biochemistry 1986; 25: 6731-6735.

Koop DR , Crump BL , Nordblom GD , Coon MJ Immunochemical evidence for induction of the ethanol-oxidizing cytochrome P450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole and isoniazid. Procedings of the National Academy of Sciences 1985; 82: 4065-4069.

Upton RA Pharmacokinetic interactions between theophylline and other medication (Part I). Clinical Pharmacokinetics 1991; 20: 66-80.

Upton RA Pharmacokinetic interactions between theophylline and other medication (Part II). Clinical Pharmacokinetics 1991; 20: 135-150.

Laaban JP et al. Theophylline intoxication following viloxazine induced decrease in clearance. European Journal of Clinical Pharmacology 1986; 30: 351-353.

Sperber AD Toxic interaction between fluvoxamine and sustained release theophylline in an 11 year old boy. Drug Safety 1991; 6: 460-462.

Robson RA , Miners JO , Birkett DJ Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism: effects on theophylline. British Journal of Clinical Pharmacology 1988; 25: 397-400.

Burnakis TG , Seldon M. , Czaplicki AD Increased serum theophylline concentrations secondary to oral verapamil. Clinical Pharmacy 1983; 2: 458-461.

Soto J. et al. Diltiazem treatment impairs theophylline elimination. Therapeutic Drug Monitoring 1994; 16: 49-52.

Derby LE et al. Hospital admission for xanthine toxicity. Pharmacotherapy 1990; 10: 112-114.

Lin JH et al. Comparative effect of famotidine and cimetidine on the pharmacokinetics of theophylline in normal volunteers. British Journal of Clinical Pharmacology 1987; 24: 669-672.

Vestal RE , Thummel KE , Musser B. Cimetidine inhibits theophylline clearance in patients with chronic obstructive pulmonary disease: a study using stable isotope methodology during multiple dose oral administration. British Journal of Clinical Pharmacology 1983; 15: 411-418.

Dal Negro R. , Pomari C. , Turco P. Famotidine and theophylline pharmacokinetics . Clinical Pharmacokinetics 1993; 24: 255-258.

Jusko WJ et al. Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates and ethanol. Journal of Pharmaceutical Sciences 1979; 68: 1358-1366.

Tornatore KM et al. Effect of chronic oral contraceptive steroids on theophylline disposition. European Journal of Clinical Pharmacology 1982; 23: 129-134.

Renton KW , Gray JD , Hung OR Depression of theophylline elimination by erythromycin. Clinical Pharmacology and Therapeutics 1981; 30: 422-426.

Zarowitz Bjm , Szefler SJ , Lasezkay GM Effect of erythromycin base on theophylline kinetics. Clinical Pharmacology and Therapeutics 1981; 29: 601- 605.

Batty KT et al. The effect of ciprofloxacin on theophylline pharmacokinetics in healthy subjects. British Journal of Clinical Pharmacology 1995; 39: 305-311.

Manfredi RL , Vesell ES Inhibition of theophylline metabolism by long-term allopurinol administration. Clinical Pharmacology and Therapeutics 1981; 29: 224-229.

Piafsky KM , Sitar DS , Rangno RE , Ogilvie RI Theophylline disposition in patients with hepatic cirrhosis. New England Journal of Medicine 1977; 296: 1495-1497.

Guengerich FP , Turvey CG Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. Journal of Pharmacology and Experimental Therapeutics 1991 ; 256: 1189-1191.

Piafsky KM , Sitar DS , Rangno RE , Ogilvie RI Theophylline kinetics in acute pulmonary oedema. Clinical Pharmacology and Therapeutics 1977; 21: 310-316.

Chang KC , Bell TD , Lauer BA , Chai H. Altered theophylline pharmacokinetics during acute respiratory virus illness . Lancet 1978; 1: 1132-1133.

Marquis J-F. et al. Phenytoin-theophylline interaction. New England Journal of Medicine 1982; 307: 1189-1190.

Kesler KM et al. Proarrhythmia related to a kinetic and dynamic interaction of mexiletine and theophylline. American Heart Journal 1989; 117: 964-966.

Hunt SN , Jusko WJ , Yurchak AM Effects of smoking on theophylline disposition. Clinical Pharmacology and Therapeutics 1976; 19: 546.

Powell JR et al. The influence of cigarette smoking and sex on theophylline disposition . American Review of Respiratory Disease 1977 ; 116: 17-23.

Troger U. , Meyer FP Influence of endogenous and exogenous effectors on the pharmacokinetics of theophylline. Clinical Pharmacokinetics 1995 ; 28: 287-314.

Rice KL et al. Aminophylline for acute exacerbations of chronic obstructive pulmonary disease. Annals of Internal Medicine 1987; 107: 305-309.

Prior JG , Berry D. , Cochrane GM Serum theophylline concentrations during multiple dosing with two sustained release methyl-xanthine preparations in normal subjects. Postgraduate Medical Journal 1980; 56: 638-641.

Anon. Theophylline benefits and difficulties. Lancet 1983; 2: 607-608.

Fairshter RD , Busse WW Theophylline - how much is enough? Journal of Allergy and Clinical Immunology 1986; 77: 646-648.

Ried LD , Horn JR , McKenna DA. Therapeutic drug monitoring reduces toxic drug reactions: A meta analysis. Therapeutic Drug Monitoring 1990 ; 12: 72-78.

Travers EM Misuse of therapeutic drug monitoring: An analysis of causes and methods for improvement. Clinics in Laboratory Medicine 1987; 7: 453-472.

Jonkman Jhg , Van der Boon Wjv. Nocturnal plasma theophylline concentrations . Lancet 1983; 1: 1278-1279.

Whiting B. Controlling theophylline therapy. Lancet 1983; 2: 966.

Mungall D. et al. Individualising theophylline therapy: the impact of clinical pharmacokinetics on patient outcomes. Therapeutic Drug Monitoring 1983; 5: 95-101.

Kirk JK et al. Salivary theophylline monitoring: reassessment and clinical considerations. Therapeutic Drug Monitoring 1994; 16: 58-66.

Weinberger MC Theophylline. PoisindexR Volume 86. 1974-1995; Micromedex Inc, Denver, USA.

Minton NA , Henry JA Treatment of theophylline overdose. American Journal of Emergency Medicinen 1996 (in press).

Amin DA , Henry JA Propranolol administration in theophylline overdose. Lancet 1985; 1: 520-521.

Wiest D. Esmolol. A review of its therapeutic efficacy and pharmacokinetic characteristics. Clin Pharmacokinet 1995; 28: 190-202.

Brown Sga , Prentice DA Ondansetron in the treatment of theophylline overdose. Med J Austr 1992; 156: 512.

Sage TA , Jones WN , Clark RF Ondansetron in the treatment of intractable nausea associated with theophylline toxicity. Ann Pharmacother 1993; 27: 584-585.

Greenberg A. , Piraino BH , Kroboth PD , Weiss J. Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents and charcoal hemoperfusion. Am J Med 1984; 76: 854-860.

Goldberg MJ , Park GD , Berlinger WG Treatment of theophylline intoxication. J Allergy Clin Immunol 1986; 78: 811-817.