Ah Receptor gene knock out mice - a model for the analysis of Ah receptor dependent and independent mechanisms of toxicity ... and more

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References

Ema M. et al. cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun 1992; 184: 246-253.

Burback KM , Poland A. , Bradfield CA Cloning of the Ah-receptor cDNA reveals a distinctive ligand activated transcription factor. Proc Natl Acad Sci USA 1992; 89: 8185-8189.

Quattrochi LC , Tukey RH Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. Mol Pharmacol 1993; 43: 504-508.

Lesca P. et al. Evidence for a ligand-independent activation of the Ah receptor . Biochem Biophys Res Commun 1995; 209: 474-482.

Enan E. , Matsumara F. Evidence for a second pathway in the action mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Biochem Pharmacol 1995; 49: 249-261.

Ma X. , Babish JG Acute 2,3,7,8-tetrachlorodibenzop-dioxin exposure results in enhanced tyrosyl-phosphorylation and expression of murine hepatic cyclin dependent kinases. Biochem Biophys Res Commun 1993; 197: 1070-1077.

Sutter TR , Guzman K. , Dold KM , Greenlee WF Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta. Science 1991; 254: 415-418.

Huff J. , Lucier G. , Tritscher A. Carcinogenicity of TCDD: experimental, mechanistic and epidemiologic evidence . Annu Rev Pharmacol Toxicol 1994 ; 34: 343-372.

Weston WM , Nugent P. , Greene RM Inhibition of retinoic-acid-induced gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin . Biochem Biophys Res Commun 1995; 207: 690-694.

10.

White TE , Gasiewicz TA The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzop-dioxin. Biochem Biophys Res Commun 1993; 193: 956-962.

11.

Kelce WR et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature 1995; 375: 581-585.

12.

Okey AB , Riddick DS , Harper PA Molecular Biology of the aromatic hydrocarbon (dioxin) receptor. TiPS 1994; 15: 226-232.

13.

Landers JP , Bunce NJ The Ah receptor and the mechanism of dioxin toxicity. Biochem J 1991; 276: 273-287.

14.

Puga A. , Nebert DW , Carrier F. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. DNA Cell Biol 1992; 11: 269-281.

15.

Teepe AG , Beck DJ , Li AP Comparison of rat liver parenchymal and nonparenchymal cells in the activation of promutagens. Env Mol Mutagen 1992; 29: 134-139.

16.

Raha A. , Wagner C. , MacDonald RG , Bresnick E. Rat liver cytosolic 4S polycyclic aromatic hydrocarbon binding protein is glycine N-methyltransferase. J Biol Chem 1994 ; 269: 5750-5756.

17.

Nebert DW Drug metabolising enzymes in ligand-modulated transcription. Biochem Pharmacol 1994; 47: 25-37.

18.

Yang LY , Namkung MJ , Juchau MR Expression of functional cytochrome P4501A1 in human embryonic hepatic tissues during organogenesis. Biochem Pharmacol 1995 ; 49: 717-726.