1 To estimate the quantitative relation between exposure to airborne n-hexane and various markers of immune function, 35 male workers were examined and compared with unexposed controls.
2 Urinary 2,5-hexanedione concentrations were signifi cantly higher in the exposed group than in the unexposed.
3 A significant suppression was observed in the serum immunoglobulin (IgG, IgM and IgA) levels between two populations. Also, a significant correlation was found between urinary 2,5-hexanedione concentrations and serum Ig level of the exposed group.
4 No significant difference between white blood cell counts was found in the two groups.
Link H.Some Aspects of Immune Reactions of the Brain, Blackwell : Oxford, 1979, pp. 12 -28.
5.
Singh KP et al. 2,5-Hexanediol induced thymic atrophy and lymphocytotoxicity in rat. Ind Health1983; 21: 235-242.
6.
Kannan K., Singh KP, Goel SK, Shanker R.Effect of 2,5-Hexanediol on immunocompetence of mice. Environ Res1985; 36: 14-25.
7.
Upreti RK, Singh KP, Saxena AK, Shanker R.Effect of 2,5-hexanedione on lymphoid organs of rats: A preliminary report . Environ Res1986; 39: 188-198.
8.
Upreti RK, Shanker R. 2,5-Hexanedione-induced immunomodulatory effect in mice. Environ Res1987; 43: 48-59.
9.
Ahonen I., Schimberg RW 2,5-Hexanedione excretion after occupational exposure to n-hexane. Br J Ind Med1988; 45: 133 -136.
10.
Perbellini L. et al. An improved method of analyzing 2,5-hexanedione in urine. Br J Ind Med1990; 47: 421-424.
11.
Donald M., Zimmer A.Atlas of Clinical Laboratory Procedures, vol 1. TheBlakiston Division, McGraw-Hill Book Company: New York , 1967.
12.
Geiger H., Hoffmann P.Quantitative immunological determination of 16 different blood proteins in 260 normal children, aged 0 to 15 years. Zeitsch Kinderheilkunde1970; 109: 22-40.
13.
Hallmann L.Klinische Chemie und Mikroskopie. George Thieme Verlag : Stuttgart1966.
14.
Descotes J.Immunotoxicology of Drugs and Chemicals, Elsevier : Amsterdam, 1988, pp. 31-48.
