Metabolites beat adducts and monitors

Friesen MD et al. Analysis of DNA adducts of 2-amino-1 -methyl-6-phenylimidazo[4,5-b]pyridine in rat and human tissues by alkaline hydrolysis and gas chromatography/electron capture mass spectrometry: validation by comparison with 32P-postlabelling . Chem Res Toxicol 1994; 7: 733-739.

Talaska G. , Al-Juburi Azss , Kadlubar FF Smoking related carcinogen DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-1)-4-aminobiphenyl as a major adduct. Proc Natl Acad Sci USA , 1991; 88: 5350-5354.

Kolman A. , Segerbäck D. and Osterman-Golkar S. Estimation of the cancer risk of genotoxic chemicals by the rad-equivalence approach. In: Methods for detecting DNA damaging agents in humans : Applications in cancer epidemiology and prevention . Bartsch H, Hemminki K, O'Neill IK (eds), IARC Scientific Publication No.89, IARC, Lyon, France, pp.258-264.