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Abstract

Fenoverine is a spasmolytic drug that inhibits calcium channel currents. We describe the clinicopathologic find ings in two patients with fenoverine-induced rhabdomyo lysis, of whom one died. A transient left-bundle-branch block was observed in both patients. In one case, pre-exist ing hepatic dysfunction may have induced accumulation of the drug. Concurrent treatment by fibrates, as observed in the second patient, may have been a predisposing factor for fenoverine-induced rhabdomyolysis. The incidence of muscular complications of fenoverine therapy could be reduced by avoidance of prescription of the drug in patients with hepatopathy or those being treated with cho lesterol-lowering agents. Physicians should be aware of life-threatening adverse effects of apparently innocuous drugs.

Keywords

fenoverine rhabdomyolysis ischemia spas molytic drug

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Fenoverine-induced rhabdomyolysis

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