The SCID mouse as a model in immunotoxicology

Bosma GC , Custer RP & Bosma MJ A severe combined immunodeficiency mutation in the mouse Nature 1983; 301 : 527-30.

Lieber MR , Hesse JE , Lewis S. , Bosma GC , Rosenberg N. , Mizuuchi K. , Bosma MJ & Gellert M. The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination Cell 1988; 55: 7-16.

Fulop GM & Phillips RA The scid mutation in mice causes a general defect in DNA repair Nature 1990; 347 : 479-82.

Hendrickson EA The SCID mouse: relevance as an animal model system for studying human disease American Journal of Pathology 1993; 143 : 1511-22.

Custer RP , Bosma GC & Bosma MJ Severe combined immunodeficiency (SCID) in the mouse American Journal of Pathology 1985; 120: 464-77.

Bosma MJ & Carroll AM The SCID mouse mutant: definition, characterization, and potential uses Annual Review of Immunology 1991; 9: 323-50.

Ashany D. , Hines J. , Gharavi A. , Mouradian J. & Elkon KB Analysis of autoantibody production in SCIDsystemic lupus erythematosus (SLE) chimeras Clinical & Experimental Immunology 1992; 88: 84-90.

Bosma GC , Fried M. , Custer RP , Carroll A. , Gibson DM & Bosma MJ Evidence of functional lymphocytes in some (leaky) SCID mice Journal of Experimental Medicine 1988; 167: 1016-33.

Bosma MJ B and T cell leakiness in the SCID mouse mutant Immunodeficiency Reviews 1992; 3: 261-76.

Donjon CM , Morkowski H. , Cheung RK , Leeder JS & Dosch H-M. Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence. Journal of Immunology 1993; 151: 5948-54.

Sprent J. , Schaefer M. , Hurd M. , Surh CD & Ron Y. Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype Journal of Experimental Medicine 1991; 174 : 717-28.

Mosier DE , Gulizia RJ , Baird SM & Wilson DB Transfer of a functional human immune system to mice with severe combined immunodeficiency Nature 1988 ; 335: 256-9.

Nadal D. , Albini B. , Scläpfer E. , Chen C. , Brodsky L. & Ogra PL Tissue distribution of mucosal antibody-producing cells specific for respiratory syncytial virus in severe combined immune deficiency (SCID) mice engrafted with human tonsils Clinical & Experimental Immunology 1991; 85: 358-64.

Thirdborough SM , Chamberlain JC , Swift SM , James Rfl & London Njm. The kinetics of SCID-hu reconstitution: a comparison between human splenocytes and peripheral blood leukocytes Cell Transplantation 1993; 2: 339-43.

Saeki Y. , Mima T. , Sakoda S. , Fujimura H. , Arita N. , Nomura T. & Kishimoto T. Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients Proceedings National Academy of Sciences USA 1992; 89: 6157-61.

Schönbeck S. , Padberg F. , Marx A. , Hohlfeld R. & Wekerle H. Transplantation of myasthenia gravis thymus to SCID mice Annals of the New York Academy of Sciences 1993; 681: 66-78.

Kumpel BM , Poole GD & Jackson DJ Specific anti-A responses of SCID mice populated with human lymphoid cells from peripheral blood, umbilical cord, bone marrow and spleen after immunization with group A erythrocytes. Immunology Letters 1992; 33: 163-8.

Duchosal MA SCID mice in the study of human autoimmune diseases Springer Seminars in Immunopathology 1992; 14: 159-77.

Carlsson R. , Mårtensson C. , Kalliomäki S. , Ohlin M. , Borrebaeck Cak. Human peripheral blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are a source of immunocytes for the production of human monoclonal antibodies Journal of Immunology 1992; 148 : 1065-71.

Duchosal MA , Eming SA , Fischer P. , Leturcq D. , Barbas CF III , McConahey PJ , Caothien RH , Thornton GB , Dixon FJ & Burton DR Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries. Nature 1992; 355: 258-62.

Aaberge IS , Michaelsen TE , Rolstad AK , Groeng E-C. , Solberg P. & Løvik M. SCID-hu mice immunized with a pneumococcal vaccine produce specific human antibodies and show increased resistance to infection Infection and Immunity 1992; 60 : 4146-53.

Hoffmann-Fezer G. , Kranz B. , Gall C. , Thierfelder S. Peritoneal sanctuary for human lymphopoiesis in SCID mice injected with human peripheral blood lymphocytes from Epstein-Barr virus-negative donors European Journal of Immunology 1992; 22: 3161-66.

Ladel CH , Kaufmann She , Bamberger U. Localization of human peripheral blood leukocytes after transfer to C.B-17 scid/scid mice. Immunology Letters 1993; 38: 63-8.

Hoffmann-Fezer G. , Gall C. , Zengerle U. , Kranz B. , Thierfelder S. Immunohistology and immunocytology of human T-cell chimerism and graft-versus-host disease in SCID mice. Blood 1993; 12: 3440-48.

Hesselton RM , Koup RA , Cromwell MA , Graham BS , Johns M. , Sullivan JL Human peripheral blood xenografts in the SCID mouse: characterization of immunologic reconstitution Journal of Infectious Diseases 1993; 168: 630-40.

Okano M. , Taguchi Y. , Nakamine H. , Pirruccello SJ , Davis JR , Beisel KW , Kleveland KL , Sanger WG , Fordyce RR , Purtilo DT Characterization of Epstein-Barr virus induced lymphoproliferation derived from human peripheral blood mononuclear cells transferred to severe combined immunodeficient mice American Journal of Pathology 1990; 137: 517-22.

MacLennan Icm & Gray D. Antigen-driven selection of virgin and memory B cells Immunological Reviews 1986 ; 91: 61-85.

McCune JM , Namikawa R. , Kaneshima H. , Shultz LD , Lieberman M. & Weissman IL The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 1988; 241: 1632-9.

McCune JM , Péault B. , Streeter PR & Rabin L. Preclinical evaluation of human hematolymphoid function in the SCID-hu mouse Immunological Reviews 1991; 124: 45-62.

McCune JM , Namikawa R. , Shih C-C. , Rabin L. & Kaneshima H. Suppression of HIV infection in AZTtreated SCID-hu mice Science 1990; 247 : 564-6.

Barry TS , Jones DM , Richter CB & Haynes BF Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens Journal of Experimental Medicine 1991; 173: 167-80.

Martin A. , Valentine M. , Unger P. , Lichtenstein C. , Schwartz AE , Friedman EW , Shultz LD & Davies TF Preservation of functioning human thyroid organoids in the scid mouse: 1. System characterization Journal of Clinical Endocrinology and Metabolism 1993; 77: 305-10.

Sacci JB , Schriefer ME , Resau JH , Wirtz RA , Detolla LJ , Markham RB & Azad AF Mouse model for exoerythrocytic stages of Plasmodium falciparum malaria parasite Proceedings of the National Academy of Sciences USA 1992; 89: 3701-5.

Pollock PL , Germolec DR , Comment CE , Rosenthal GJ & Luster MI Development of human lymphocyte-engrafted SCID mice as a model for immunotoxicity assessment Fundamental and Applied Toxicology 1994; 22: 130-8.

De Heer C. , Verlaan Apj , Penninks AH , Schuurman H-J. & van Loveren H. The SCID-ra mouse: rat T-cell differentiation in the severe combined immunodeficient mouse APMIS 1993; 101: 467-79.

Smith Cie , Abedi MR , Islam KB , Johansson Meb , Christensson B. & Hammarström L. Humoral immunity in scid mice reconstituted with cells from immunoglobulin-deficient or normal humans Immunological Reviews 1991; 124: 1-26.

Kilchherr E. , Mandak V. , Wagner K. & Heusser CH Regulation of human IgE response in hu-PBL-SCID mice Cellular Immunology 1993; 151: 241-56.

Mombaerts P. , Iacomini J. , Johnson RS , Herrup K. , Tonegawa S. & Papaioannou VE RAG-1-deficient mice have no mature B and T lymphocytes Cell 1992; 68: 869-77.