Male rats were exposed to manganese sulphate i.p. daily for a period of four weeks to see its effects on tissue levels and urinary excretion of total nicotinamide nucleotides (TNN). Increased levels of TNN were observed in blood and brain while the levels were found to be decreased in liver. There was a progressive increase in the excretion of TNN during the experimental period, TNN levels in blood and urine might serve as useful biological indicators of Mn toxicity.
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