Urinary proteins have been found to be a sensitive marker of renal damage caused by nephrotoxic agents. An electrophoretic method was used to investigate the potential value of the pattern of urinary protein excretion in 14 cyclosporin-treated renal transplant patients, to differentiate between graft rejection episodes and other causes of renal dysfunction. Urinary protein excretion consistent with renal damage was observed in all of the patients studied, with no marked differences between those with signs of graft rejection, those with renal dysfunction, or those with stable renal function.
Get full access to this article
View all access options for this article.
References
1.
Hossein-Nia M. , Devlin J., Tredger J., Fagbohun M., Williams R. & Holt DWUrinary proteins as a marker of drug-induced renal damage following treatment with Cyclosporin or FK 506. Transplant Proceedings1991; 23: 3150-2.
2.
Stierle HE, Oser B. & Boesken WHImproved classification of proteinuria by semi-automated ultrathin SDS polyacrylamide gel electrophoresis. Clinical Nephrologoy1990; 33: 168-73.
3.
Kahan BD: CyclosporineNew England Journal of Medicine1989; 321: 1725-38.
4.
Revillard JP, Manuel Y., Betuel H., Fries D. & Traeger J.Proteinuria in human allografts-sequential studies. Proteins in normal and pathological urine. Manuel Y, Revillard JP, Betuel H (eds.). Basel: S. Karger, 1970; p. 309.
5.
Hemmingsen L. , Jensen H., Skaarup P., Tetschke KI & Wallin ALThe predictive value of specific protein clearances in detecting acute rejection episodes after renal transplantation. ClinicalNephrology1976; 5:
6.
Ravnskov U.Proteinuria after human renal transplantation. II. A functional identification of two types of rejection crisis. Scandinavian Journal of Urology andNephrology1974; 8: 45-9.
7.
Sethi K., First MR, Pesce AJ, Fidler JP & Pollak VEProteinuria following renal transplantation. Nephron1977; 18: 49-59.
8.
Vathsala A., Verani R., Schoenberg L., Lewis RM, Van Buren CT, Kerman RH & Kahan BDProteinuria in cyclosporin-treated renal transplant recipients. Transplantation1990; 49: 35-41.
9.
Taube DH, Gwyn Williams D, Hartley B. et al. Differentiation between allograft rejection and cyclosporin nephrotoxicity in renal-transplant recipients. Lancet1985; ii: 171-4.
10.
Burghard R. , Galaske RG, Offner G., Ehrich Jhh, Leititis JU & Brodehl J.Urinary protein analysis in the early detection of acute rejection episodes after renal transplantation in children. ClinicalNephrology1986; 26: 1-6.
