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Abstract

1 The approximate lethal dose (ALD) of six chlorinated hydrocarbons via the intratracheal route has been determined in rats and compared with published oral LD₅₀ values.

2 The compounds tested in this study were dichloromethane, perchloroethylene, trichloroethylene, carbon tetrachloride, chloroform and ethylene dichloride.

3 A method of administering the materials intratracheally to unanaesthetized animals was developed.

4 The intratracheal ALD of the chlorinated hydrocarbons ranged from 3.1 to 17.5% of the oral LD₅₀ and death was peracute.

5 Aspiration of chlorinated hydrocarbons may present more of a hazard than oral toxicity and should be considered when rendering first aid or emergency medical treatment.

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Acute Toxicity in Rats of Chlorinated Hydrocarbons Given via the Intratracheal Route

Abstract

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