Drug Interaction between Rifampicin and Cotrimoxazole in Patients with Tuberculosis

Abstract

1 Patients ( n = 15) who were admitted with complications of tuberculosis, were given antitubercular therapy (ATT) with rifampicin (RIF), for a minumum period of 15 d, and cotrimoxazole (CTZ), concurrently, for 5-10 d.

2 The serum RIF levels were measured before the start of CTZ treatment and at the end of its administration.

3 The plasma half-life (t½) of RIF increased significantly from 1.92 ± 0.57 h to 2.31 ± 0.134 h after CTZ treatment.

4 The mean serum levels of RIF increased significantly at 4 and 6 h after CTZ administration.