A case of poisoning with 100 mg of oxybutynin in a 34-year-old female is reported. The main features were anticholinergic effects, including stupor, followed by disorientation and agitation on awakening, dilated pupils, dry skin and retention of urine. She had a sinus tachycardia which resolved 3 h after admission, and in addition ventricular ectopics and bigeminy which continued for a further 30 h. She recovered fully on symptomatic treatment alone.
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References
1.
Diokno AC & Lapides J.Oxybutynin: a new drug with analgesic and anticholinergic properties. The Journal of Urology1972; 108: 307-9.
2.
Fredericks CM , Anderson GF & Kruelen DLA study of the anticholinergic and antispasmodic activity of oxybutynin (Ditropan) on rabbit detrusor. Investigative Urology1975; 12: 317-19.
3.
Lish PM, Labudde JA, Peters EL & Robbins SIOxybutynin - a musculotropic antispasmodic drug with moderate anticholinergic action. Archives Internationales de Pharmacodynamie et de Therapie1965; 156: 467-8.
4.
Douchamps J. , Derenne F., Stockis A. et al. The Pharmacokinetics of Oxybutynin in man. European Journal of Clinical Pharmacology1988; 35: 515-20.
5.
Lindeke B., Brotell H., Karlen B., Rietz G. & Vietorisz A.Determination of Oxybutynin in serum and urine by gas chromatography/mass spectrometry with single ion detection. Acta Pharmaceutica Suecica1981; 18: 25-34.
6.
Brooks ME & Braf ZFOxybutynin chloride (Ditropan)- clinical uses and limitations. Paraplegia1980; 18: 64-8.
7.
Thompson IM & Lauvetz R.Oxybutynin in bladder spasm, neurogenic bladder, and enuresis. Urology1976; 8: 452-54.
8.
Paulson DFOxybutynin chloride in control of post-trans-urethral vesical pain and spasm . Urology1978; 11: 237-8.
9.
Aaltonen L., Allonen H., Lisalo E. et al. Antimuscarinic activity of oxybutynin in the human plasma quantitated by a radioreceptor assay. Acta Pharmacologica et Toxicologica1984; 55: 100-3.
