5-Hydroxymethylfurfural (5-HMF) is a major breakdown product occurring in high concentrations in fructose and glucose solutions. Most of its formation occurs during autoclaving but spontaneous breakdown also takes place. We incubated human blood cells (granulocytes, erythrocytes and thrombocytes) with 5-HMF in the following concentrations 73.5, 735 μM and 7.35 mM. Heat output was increased in erythrocytes at the highest concentration by about 60%. An adverse effect was seen in granulocytes where a statistically significant reduction in heat output, of about 17%, was found (P < 0.05). No influence upon the metabolic activity of thrombocytes could be detected.
Get full access to this article
View all access options for this article.
References
1.
Jellum E., Borresen HC & Eldjarn L.The presence of furan derivatives in patients receiving fructose containing solutions intravenously. Clinical Chimical Acta1973; 47: 191-201.
2.
Ulbricht RI, Northup SI & Thomas AIA review of 5-hydroxymethyl furfural in parenteral solutions. Fundamental Applied Toxicology1984; 4: 843-53.
3.
Wadhwa N., Kenward D., Kennedy B., Rowe S.Heating of peritoneal dialysis fluid by a microwave oven in hospital practice - a new method of choice. Peritoneal Dialysis Bulletin1983; 3: 187-8.
4.
Nakao M., Nakayama T. & Kankura T.A new method for separation of human blood components. Nature (New Biology)1973; 246: 93.
5.
Suurkuusk I. & Wadsö I.A multichannel microcalorimetry system. Chemica Scripta1982; 20: 155-63.
6.
Hessow I.Toxicity of 5-hydroxymethylfurfural and furfural to Daphnia magna. Acta Pharmacologica Toxicolica1975; 37: 94-6.
7.
Lang K. & Bickel H.Untersuchungen über die Verträglichkeit von 5-(hydroxymethyl-2-furfural (5-HMF)Zeitschrift für Ernährwochenschrift.1970 ; 10: 153-4.
8.
Germond IE, Philippossian G., Richli U., Bracco I., Arnaud MIRapid and complete urinary elimination of (14C) - 5-hydroxymethyl-2-furaldelyde administered orally or intravenously to rats. I. Toxicology and Environmental Health1987; 22: 79-89.
9.
Castellino N. , Elmino O. & Rozera G. (1963). Experimental research on toxicity of furfural. Archives of Environmental Health7: 574-82.
10.
Schoental R. , Hard GC, Gibbard S.Histopathology of renal lipomatous tumours in rats treated with the natural products, pyrrolizidine alkaloids and alpha, beta - unsaturated aldelydes. I. Journal of the National Cancer Institute1971; 47: 1037-44.
11.
Pettersen JE & Jellum E.The identification and metabolic origin of 2-Furoylglycine and 2,5-Furandicarboxylic acid in human urine. Clinical Chimica Acta1972; 41: 199-207.
12.
Yoshisuke N. , Yoshifumi M. & Kunio K.Chromosome aberration induced by pyrolysates of carbohydrates in chinese hamster U 79 cells. Mutation Research1989; 277: 117-23.
