Two cases of organophosphorus poisoning are reported. Both were treated with a combination of atropine and glycopyrrolate as well as benzodiazepine and pralidoxime. The advantages of glycopyrrolate over atropine are discussed.
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References
1.
Martindale: The Extra Pharmacopoeia . 29th edn. London: The Pharmaceutical Press, 1989.
2.
Cozantis DA, Tuominen M. & Kauste A.The postoperative drying effects of atropine and glycopyrrolate. Anaesthesia1982; 37: 86-7.
3.
Sengupta A., Gupta PK & Pandey K.Investigation of glycopyrrolate as a premedicant drug. British Journal ofAnaesthesia1980; 52: 513-616.
4.
Cozantis DA & Jones CJAsystole not corrected by glycopyrronium. Anaesthesia1988; 43: 247.
5.
Sheref SEPatterns of CNS recovery following reversal of neuro-muscular blockade. British Journal ofAnaesthesia1985; 57: 188-191.
6.
Proakis AG & Harris GBComparative penetration of glycopyrrolate and atropine across the blood-brain and placental barriers in anesthetised dogs. Anesthesiology1979; 48: 339-44.
7.
deKort W., Kiestra SH & Sangester B.The use of atropine and oximes in organophosphate intoxification: a modified approach. Clinical Toxicology1988; 26: 199-208.
8.
Senanayake N. & Karalliedde N.Neurotoxic effects of organophorphorus insecticides. New England Journal of Medicine1987; 316: 761-3.