The activity of various inhibitors on several subcellular enzymes was studied. First we determined the inhibitory concentration required to reduce maximum enzymatic activity by 50%, then the effect of various hahnemannian dilutions of the same inhibitory agent was tested. Seven inhibitory agents were tested in this way on seven different enzymatic systems. No effects of these hahnemannian dilutions were shown.
Get full access to this article
View all access options for this article.
References
1.
Devraigne P. , Bagros M. & Boiron H.Etude experimentale de l'activité biologique de dilutions homéopathiques de folliculine. Gynécologie Pratique1954; 3-4.
2.
Lapp C., Wurmser L. & Ney J.Mobilisation de l'arsenic fixe chez le cobaye sous l'influence de doses infinitésimales d'arséniate de sodium. Thérapie1955; 10: 625-38.
3.
Wurmser L.Influence des doses infinitésimales sur la cinétique des éliminations . Doc. Homéo. LHF1957: XXXIX:
4.
Mouriquand G. , Cier A., Boiron J., Edel V. & Chighizola R.Mobilisation de l'arsenic fixé sous l'effet de doses infinitésimales et variations de l'indice chronologique vestibulaire. Extrait des compte-rendus des séances de l'Académie des Sciences, 6 juillet 1959 et 24 mai 1961.
5.
Boiron J. & Cier A.Elimination provoquée et spécificité d'action des dilutions infinitésimales d'éléments toxiques. Annales Homéopathiques Françaises1962; 10789-95.
6.
Cazin JC, Cazin M., Gaborit JL, et al. A study of the effect of decimal and centesimal dilutions of arsenic on the retention and mobilization of arsenic in the rat. Human Toxicology1987; 6: 315-20.
7.
Applemans F. , Wattiaux R. & de Duve C.Tissue fraction-nation studies. 5. The association of acid phosphatase with a special class of cytoplasmic granules in rat liverBiochemical Journal1955; 59: 438-45.
8.
Emmelot P., Bos CJ, Benedetti EL & Rumke PHStudies on plasma membranes. I. Chemical composition and enzyme content of plasma membranes isolated from rat liver. Biochimica et Biophysica Acta1963; 90: 126-45.
9.
Leelavathi DE , Estes LW, Feingold DS & Lombardt B.Isolation of a golgiride fraction from rat liverBiochimica et Biophysica Acta1970; 211: 124-38.
10.
Hartree EFDetermination of protein: a modification of the Lowry method that gives a linear photometric response. Analytical Biochemistry1972; 48: 422-7.
11.
Swanson MAPhosphatases of liver. I. Glucose-6-phosphatase. Journal of Biological Chemistry1950; 184: 647-59.
12.
Nordlie RC & Arion WJEvidence for the common identity of glucose-6-phosphatase, inorganic pyrophosphatase and pyrophosphate-glucose phosphotransferase. Journal of Biological Chemistry1964; 239: 1680-5.
13.
Nordlie RC & Lygre DGThe inhibition by citrate of inorganic pyrophosphate-glucose, phosphotransferase and glucose-6-phosphatase. Journal of Biological Chemistry1966; 241: 3136-41.
14.
Schachter H. , Jabbal I., Hudgin RL et al. Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferase in a golgi-rich fraction . Journal of Biological Chemistry1970; 245: 1090-100.
15.
Douglas AP, Kerley R. & Isselbacher KJPreparation and characterization of the lateral and basal plasma membranes of the rat intestinal epithelial cell. Biochemical Journal1972; 128: 1329-38.
16.
Fitzgerald DK, McKenzie L. & Ebner KEGalactosyltransferase activity in a variety of sources. Biochim. Biophys. Acta1971; 235: 425-28.
17.
Butterford J.Properties of microsomal glycoprotein galactosyltransferase of cultured human fibroblasts in relation to cystic fibrosis. Clinica. Chimica Acta1974; 56: 159-68.
18.
Bergmeyer HUMethods of Enzymatic Analysis. 2nd edn. 1965; New York: Academic Press. pp 736-43.