Five normal newborn breast fed babies were accidentally fed a dilute antiseptic solution (chlorhexidine 0.05% with cetrimide 1%) in place of sterile water, developing caustic burns of the lips, mouth and tongue within minutes; one baby became quite severely ill due to acute pulmonary oedema, but all survived without sequelae.
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References
1.
Massano G., Ciocatto E., Rosabianca C., Vercelli D., Actis GC & Verme G.Striking aminotransferase rise after chlorhexidine self-poisoning. Lancet1982; i: 289.
2.
Chow Ayk, Hirsch G. & Buttar HSNephrotoxic and hepatotoxic effects of tuclosan and chlorhexidine in rats . Toxicology and Applied Pharmacology1977 ; 42: 1-10.
3.
Rushton A.Safety of Hibitane II. Human experience. Journal of Clinical Periodontology1977; 4: 73-9.
4.
Case DESafety of Hibitane I. Laboratory experiments. Journal of Clinical Periodontology1977; 4: 66-72.
5.
Winrow MJ, Hedgecox E., McDonald RS & Siddall J.Metabolic studies with 14C chlorhexidine ('Hibitane') in animals and man. Journal of Dental Research1973; 52: 93.
6.
Isomaa R.Reuter J. & Djupsund BMThe subacute and chronic toxicity of cetyltrimethyl ammonium bromide (CTAB), a cationic surfactant, in the rat. Archives of Toxicology1976; 35: 91-6.
7.
Davies DM (ed). Textbook of Adverse Drug Reactions , p. 653. Oxford, 1985.
8.
Arena JMPoisoning and other health hazards associated with use of detergents. Journal of the American Medical Association1964; 190: 56.
9.
ADRIS Adverse Drug Reactions Information Service report 740039 Unpublished
10.
ADRIS report 740023 Unpublished
11.
ADRIS report 660026 Unpublished
12.
Gosselin RE, Hodge HC, Smith RP & Gleason MN (eds). Clinical Toxicology of Commercial Products: Acute Poisoning, pp. 59-63. Baltimore: Williams and Wilkins, 1976.
13.
Reynolds JEF (ed). Martindale The Extra Pharmacopoeia. London: The Pharmaceutical Press, 1982.
