1 Alpha-chloralose, formed by the condensation of glucose with chloral, is used as a rodenticide and in the control of bird pests.
2 In two cases of poisoning with alpha-chloralose the clinical features included coma and generalized convulsions resembling the effects of strychnine more than those of chloral hydrate.
3 The principles of management are the support of vital functions in the unconscious patient and removal of unabsorbed poison by gastric lavage. Diazepam may be used to control convulsions.
Get full access to this article
View all access options for this article.
References
1.
Lees P.Pharmacology and toxicology of alpha-chloralose: a review. The Veterinary Record1972; 91: 330-3.
2.
Brown PM, Bunyan PJ & Stanley PIThe investigation and pattern of occurrence of animal poisoning resulting from the misuse of agricultural chemicals. Journal of theForensic Science Society1977; 17: 211-21.
3.
Balis GU & Monroe RRThe pharmacology of chloralose: a review. Psychopharmacologia1964; 6: 1-30.
Moene Y., Girard P., Cuche M., Trillet M., Motin J. & Michel D.Problemes diagnostiques poses par l'intoxication aigue au chloralose. Bulletin de Médecine Légale et de Toxicologie Médicale1968 ; 11: 362-72.
6.
Goulding R.Poisoning due to pesticides. In Poisoning: Diagnosis and Treatment . eds JA Vale & TJ Meredith, Update Books Ltd., London , 1981, p. 150.
7.
Mirjolet M., Semars M., de Ren G. & Petiet G.Dosage spectrophotometrique du chloralose dans les milieux biologigues à la suite d'intoxications. Bulletin de la Société Pharmaciée de Nancy1969; 83: 7-14.
8.
Cheramy MPSur la recherche du chloralose dans l'urine. Journal de Pharmacie et de Chimie (Paris) 9th series 1940 ; 1: 233-4.
9.
Shita A., Cornil A. & Ectors M.Aspects cliniques et electroencephalographiques d'une intoxication sévère a l'alphachloralose. Acta Clinica Belgica1981; 36: 20-4.
Frejaville J-P. , Christoforov B., Bismuth C., et al. In Toxicologie Clinique et Analytique , p. 286. Paris: Flammarion Medicine Sciences, 1971.
12.
Manzo L., Richelmi P., Crema A., Allaria B. & Caputo E.Electrocerebral changes in acute alpha-chloralose poisoning: a case report . Veterinary and Human Toxicology1979; 21: 245-7.
13.
Mascre M., Maillard G. & Loiseau J.Sur la recherche simultanée des barbituriques, du chloralose et du chloral dans l'urine et dans le sang. Bulletin des Sciences Pharmacologiques1940; 47: 281-5.
14.
Frejaville J-P. , Christoforov B., Bismuth C., et al. In Toxicologie Clinique et Analytique , p. 286. Paris: Flammarion Medicine Sciences, 1971.
