Influence of Age and Consumption of Tobacco,Alcohol and Caffeine on Antipyrine Clearance

Abstract

1 Antipyrine clearance and average daily consumption of tobacco, alcohol and coffee/tea were determined in 303 healthy men.

2 The antipyrine clearance was positively correlated with the consumption of tobacco (r = 0.24; P < 0.0001) and coffee/tea (r = 0.18; P < 0.001), and negatively with age (r = -0.14; P < 0.05) and the alcohol consumption (r = —0.13; P < 0.05).

3 The multiple regression coefficients suggested an increase in antipyrine clearance of 0.8% per daily cigarette or cup of tea and 1.4% per daily cup of coffee; the decrease per daily drink or year of age was 2.8% or 0.4%, respectively.