Free Radicals and Antioxidant Protection: Mechanisms and Significance in Toxicology and Disease

Slater TF Free radical mechanisms of tissue injury. Biochemical Journal 1984; 222: 1-15.

Halliwell B. & Gutteridge Jmc. Free Radicals in Biology and Medicine. Oxford: Clarendon Press, 1985.

Saez G. , Thornalley PJ , Hill Hao , Hems R. & Bannister JV The production of free radicals during the oxidation of cysteine and their effect on isolated rat hepatocytes. Biochimica et Biophysica Acta 1982; 719: 24-31.

Hill Hao. Dioxygen-derived radicals in biological systems. Philosophical Transactions of the Royal Society 1985; B311: 605-15.

Halliwell B. & Gutteridge Jmc. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Archives of Biochemistry and Biophysics 1986; 246: 501-14.

Free radical metabolites of toxic chemicals (special issue) . Environmental Health Perspectives 1985; 64: 1-342.

Fridovich I. Superoxide radical: an endogenous toxicant. Annual Review of Pharmacology and Toxicology 1983; 26: 239-57.

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Church DF & Pryor WA Free-radical chemistry of cigarette smoke and its toxicological implications . Environmental Health Perspectives 1985; 64: 111-26.

Nakayama T. , Kaneko M. , Kodama M. & Nagata C. Cigarette smoke induces DNA single-strand breaks in human cells. Nature 1985; 314: 662-4.

Halliwell B. & Gutteridge Jmc. The importance of free radicals and catalytic metal ions in human disease. Molecular Aspects of Medicine 1985; 8: 89-93.

McCord JM Oxygen-derived free radicals in post-ischaemic tissue injury. New England Journal of Medicine 1985; 312: 159-63.

Halliwell B. & Grootveld M. The measurement of free radical reactions in humans. Some thoughts for future experimentation FEBS Letters 1987; 213: 9-14.

Fridovich I. Biological effects of the superoxide radical . Archives of Biochemistry and Biophysics 1986; 247: 1-11.

Hoffman ME , Mello-Filho AC & Meneghini R. Correlation between cytotoxic effect of H2O2 and the yield of DNA strand breaks in cells of different species. Biochemica et Biophysica Acta 1984; 781: 234-8.

Carson DA , Seto S. , Wasson DB & Carrera CJ DNA strand breaks, NAD metabolism and programmed cell death. Experimental Cell Research 1986; 164: 273-81.

Schraufstatter IU , Hinshaw DB , Hyslop PA , Spragg RG & Cochrane CG Oxidant injury of cells. Journal of Clinical Investigation 1986; 77: 1312-20.

Orrenius S. Oxidative stress studied in intact mammalian cells Philosophical Transactions of the Royal Society 1985; B311: 673-7.

Albert A. Selective Toxicity. London, New York: Chapman and Hall, 1985.

Eklow-Lastbom L. , Rossi L. , Thor H. & Orrenius S. Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes. Free Radical Research Communications 1986; 2: 57-68.

Halliwell B. & Gutteridge Jmc. Lipid peroxidation, oxygen radicals, cell damage and antioxidant therapy. Lancet 1984 ; i: 1396-8.

Esterbauer H. , Cheesman KH , Dianzani MU , Poli G. & Slater TF Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe 2+ in rat liver microsomes. Biochemical Journal 1982; 208:129-40.

Thompson S. & Smith MT Measurement of the diene conjugated form of linoleic acid in plasma by HPLC: a questionable non-invasive assay of free radical activity? Chemico-Biological Interactions 1985; 55: 357-66.

Gutteridge Jmc. Aspects to consider when detecting and measuring lipid peroxidation. Free Radical Research Communications 1986; 1: 173-84.

Gutteridge Jmc. Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Letters 1986; 201: 291-5.

Biemond P. , Van Eijk HG , Swaak Ajg & Koster JF Iron mobilization from ferritin by O2- derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation disease. Journal of Clinical Investigation 1984; 73: 1576-9.

Gutteridge Jmc. Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin. A study of their acitivity in serum and synovial fluid from patients with rheumatoid arthritis. Biochemica et Biophysica Acta 1986; 869: 119-27.

Aruoma OI & Halliwell B. Superoxide-dependent and ascorbate-dependent formation of OH radicals from H2O2 in the presence of iron. Biochemical Journal 1987; 241: 273-8.

Sies H. Biochemistry of oxidative stress. Agewandte Chemie (international edition) 1986; 25: 1058-71.

Halliwell B. & Gutteridge Jmc. Iron and free radical reactions: two aspects of antioxidant protection. Trends in Biochemical Sciences 1986; 11: 372-5.

Halliwell B. , Wasil M. & Grootveld M. Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. FEBS Letters 1987; 213: 15-8.

Daniel JW Metabolic aspects of antioxidants and preservatives. Xenobiotica 1986; 16: 1073-8.

Ames BN Dietary carcinogens and anticarcinogens. Science 1983; 221: 1256-64.

Grootveld M. & Halliwell B. Measurement of allantoin and uric acid in human body fluids. Biochemical Journal, 1987 ; 243: 803-8.

Diplock AT. (ed.) Vitamin E. In Fat-Soluble Vitamins, pp. 154-224. London: Heinemann, 1985.

Cross CE , Halliwell B. & Allen A. Antioxidant protection: a function of tracheobronchial and gastrointestinal mucus. Lancet 1984; i: 1328-30.

Marx G. & Chevion M. Site-specific modification of albumin by free radicals. Biochemical Journal 1986; 236: 397-400.

Dizdaroglu M. & Bertgold DS Characterization of free radical-induced base damage in DNA at biologically relevant levels. Analytical Biochemistry 1986; 156: 182-8.

Van Kuijk FJGM, Sevanian A, Handelman GJ & Dratz EA. A new role for phospholipase A2: protection of membranes from lipid peroxidation damage. Trends in Biochemical Science 1987; 12: 31-4.

Dean RT & Pollak JK Endogenous free radical generation may influence proteolysis in mitochondria . Biochemical and Biophysical Research Communications 1985; 126: 1082-9.

Greenwald RA Therapeutic benefits of oxygen radical scavenger treatments remain unproven. Journal of Free Radicals in Biology and Medicine 1985; 1: 173-7.

Moorhouse CP , Grootveld M. , Halliwell B. , Quinlan G. & Gutteridge Jmc. Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Letters 1987; 213: 23-8.

Cross AR & Jones Otg. The effect of the inhibitor diphenylene iodonium on the O2 --generating system of neutrophils. Biochemical Journal 1986; 237: 111-6.