In rabbits anaesthetized with urethane, intravenous infusion of the iron-chelating drug desferrioxamine causes a reduction in the amplitude of the electroretinogram. This is most pronounced for weak light intensities, but the change is more complex than a mere reduction in sensitivity. In experiments lasting up to 3 days the effect is reversible and is not accompanied by electron-microscopical histological changes.
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References
1.
Albahary, C., Renault, J., Labarre, P. & Giraud, J. (1962). Le traitment des sidérose par la desferrioxamine B. Comparaison avec l'action de deux autres chélateurs. Presse Med., 70, 2823-2826.
2.
Arden, G.B., Wonke, B., Kennedy, C. & Huehns, E.R. (1984). Ocular changes in patients undergoing long term desferrioxamine therapy. Br. J. Ophthalmol., 68, 873-878.
3.
Arden, G.B., Carter, R.M., Hogg, C.R., Powell, D.J., Ernst, W.J.K., Clover, G.M., Lyness, A.L. & Quinlan, M.P. (1983). A modified ERG technique and the results obtained in X-linked retinitis pigmentosa. Br. J. Ophthalmol., 67, 419-430.
4.
Barry, M., Flynn, D.M., Letsky, F.A. & Risdon, R.A. (1974). Long-term chelation therapy in thallasaemia major: effect on liver iron concentration, liver histology and clinical progress . Br. Med. J., ii, 16-20.
5.
Blake, D.R., Winyard, P., Lunec, J., Good, P.A., Crewes, S.J., Gutteridge, J.M.C., Rowley, D., Halliwell, B., Cornish, A. & Hider, R.C. (1985). Cerebral and ocular toxicity induced by desferrioxamine . Q. J. Med. (new series 56) 219,344-355.
6.
Borgna-Pignatti, C., De Stephano, P. & Broglia, A.M. (1984). Visual loss in a patient on high-dose subcutaneous desferrioxamine. Lancet, i, 681.
7.
Davies, S.C., Marcus, R.E., Hungerford, J.L., Miller, M.H., Arden, G.B. & Huehns, E.R. (1983). Ocular toxicity of high dosage desferrioxamine . Lancet, i, 181-184.
8.
Declercq, S.S. (1980). Desferrioxamine in ocular siderosis: a long term electrophysiological evaluation. Br. J. Ophthalmol., 64, 626-629.
9.
Hoffbrandt, A.V., Gorman, A., Laulicht, M., Garidi, M., Economidou, J., Georgio-Poulou, P., Hussain, M.A.M. & Flynn, D.M. (1979). Improvement in iron status and liver function in patients with transfusional iron overload with long term subcutaneous desferrioxamine . Lancet, i, 947-949.
10.
Korte, G.E., Belhorn, R.W. & Burns, M.S. (1984). Urethane induced rat retinopathy: plasticity of the blood retinal barrier in disease. Invest. Ophthalmol. Visual. Sci., 25, 1027-1034.
11.
Linsenmeier, R.A. & Steinberg, R.H. (1984). Delayed basal hyperpolarisation of cat retinal pigment epithelium and its relation to the fast oscillation of the DC electroretinogram. J. Gen. Physiol., 83, 213-232.
12.
Melchionda, C., Leonardi, A. & Valvo, A. (1965). Ricerche sperimentali sul passaggio della Desferrioxamina B' in camera anteriore. Ann. Ottal. Clin. Oculist., 91, 1266-1272.
13.
Tripod, J. (1963). Tierexperimenteller Nachweis der Affinitat von Desferal fur Eisen. Schweiz. Med. Wochenschr., 93, 969-973.
14.
Zaino, E.C. (1977). In Chelation Therapy in Chronic Iron Overload , eds E. C. Zaino & R. H. Roberts, pp. 95-101. Symposia Specialists.
