Abstract
1 A case report of impaired exercise tolerance during administration of broxyquinoline-brobenzoxaldine combination in therapeutic doses is presented.
2 The first author of this paper, a 28-year-old healthy male, volunteered as a subject for a prospective study on the neurotoxicity of halogenated hydroxyquinolines and took a course of broxyquinoline-brobenzoxaldine combination.
3 The author, who is a karate enthusiast, observed impairment of exercise tolerance during the course of treatment with the drugs.
4 A challenge course of treatment with the same drugs in the same doses produced similar effects.
5 Since halogenated hydroxyquinolines are still used widely in many countries, such an adverse effect would be of practical relevance, particularly in asymptomatic cyst-passers of Entamoeba histolytica whose occupations involve physical labour.
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