1 A 61-year-old man ingested a large amount of carbon tetrachloride, well in excess of the adult lethal dose.
2 The level of the compound was assayed in his blood and the levels were the highest ever recorded by the Guy's Hospital Poisons Unit.
3 He was treated by intravenous infusion of acetylcysteine and survived with relatively mild clinical and biochemical evidence of toxicity.
4 Possible reasons for his survival are discussed, as are the implications for the management of future cases.
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References
1.
Angeli-Greaves, M. & Mclean, A.E.M. (1979). The effect of diet on the toxicity of drugs. In Drug Toxicity, ed. J. W. Gorrod, pp. 91-97. London: Taylor and Francis.
2.
Bagnasco, F.M., Stringer, B. & Muslim, A.M. (1978). Carbon tetrachloride poisoning: radiographic findings. New York State. J. Med., March, 646-647.
3.
Bowman, W.C. & Rand, M.J. (1980). The liver. In Textbook of Pharmacology , 2nd edn, pp. 26.20-26.23. Oxford: Blackwell Scientific Publications.
4.
Dreisbach, R.H. (1971). Halogenated hydrocarbons. In Handbook of Poisoning, pp. 131-133. Los Altos: Lange Medical Publishing.
5.
Meredith, T.J. & Vale, J.A. (1983). The halogenated hydrocarbons. In Poisoning and Drug Overdose , eds L. M. Haddad & J. F. Winchester , pp. 780-783. Philadelphia: W.B. Saunders.
6.
Ramsey, J.D. & Flanagan, R.J. (1981). Detection and identification of volatile organic compounds in blood by headspace gas chromatography as an aid to the diagnosis of solvent abuse. J. Chromatogr., 240, 423-444.