1 Ergot alkaloids and their dihydrogenated methanesulphonate (ms) salts were determined and measured in human plasma.
2 High-performance liquid chromatography (HPLC) with fluorometric detection was used for separation of ergot alkaloids in plasma.
3 Several ergot alkaloids and their derivatives, including lysergide (LSD), can be identified in cases of poisoning.
Get full access to this article
View all access options for this article.
References
1.
Aellig, W.H. & Nusch, E. (1977). Comparative pharmacokinetic investigation with tritium labelled ergot alkaloids after oral and intravenous administration in man. Int. J. Clin. Pharmacol., 15, 106-112.
2.
Aiache, J.M., Briot, M., Couquelet, J. & Vigo, P. (1981). Comparative blood level of dihydroergotoxine after administration of two oral forms. Eur. J. Drug Metab. Pharmacokinet. , 6,221-224.
3.
Humbert, H., Lavene, D., Guillaume, M.F. & Kiechel, J.R. (1981). Pharmacocinetique de deux derives ergotes: la dihydroergotoxine, la dihydroergotamine, biodisponibilite comparative de differentes formulations per rapport aux formes solutions. I. Congr. Eur. de Biopharmaceutique et Pharmacocinetique, Clermont-Ferrand, France, 1-3 April 1981.
4.
Kiechel, J.R. (1979). Pharmacocinetique et metabolisme des derives de l'ergot. J. Pharmacol. (Paris), 10, 533-565.
5.
Kleimola, T., Mäntyla, R. & Konto, J. (1977). Renal excretion of dihydrogenated alkaloids of ergotoxine in man. Acta Pharmacol. Toxicol., 40, 541-544.
6.
Kopitar, Z., Milovac, J., Vrhovac, B. & Tadjer, I. (1982). Comparison of the bioavailability of Redergin tablets (1.0 mg) and Redergin solution. Int. J. Clin. Pharmacol. Ther. Toxicol., 20, 134-138.
7.
Koskinen, E.H. & Kleimola, T. (1976). Radioimmunoassay of ergot alkaloids in biological fluids. Acta Physiol. Scand. Suppl., 440, 122.
8.
Loddo, P., Spano, P.F. & Trabucchi, M. (1976). Urinary elimination of dihydroergotoxine after oral administration and intravenous infusion. Bull. Clin. Farm., 115, 570-574.
9.
Marzo, A., Ghirardi, P., Merlo, L. & Marchetti, G. (1978). Absorption and excretion of dihydroergotoxine and dihydroergotamine in dog. Il Farmaco, 33, 477-483.
10.
Povšič, L., Hercog, B. & Kopitar, Z. (1983). Radioimmunoassay of dihydroergotoxine in plasma . Period. Biol., 85 (Suppl. 3), 251-252.
11.
Sperling, A.P. (1969). A rapid analysis of LSD. Microgram , 2, 51-55.
12.
Zecca, L., Bomini, L. & Barregi, S.R. (1983). Determination of dihydroergocristine and dihydroergotamine by high-performance liquid chromatography with fluorescence detection. J. Chromatogr., 272, 401-405.
13.
Žorž, M., Marušič, A., Smerkolj, R. & Prošek, M. (1983). Quantitative determination of low concentrations of DHETX m.s. in human plasma by high performance liquid chromatography with fluorescence detection. J. High Resolut. Chromatogr. Chromatogr. Commun., 6, 306-309.
