1 both inhaled (2 μmol/kg) and injected (30 μmol/kg) diethylenetriaminepentaacetic acid (DTPA) can reduce the lung deposit of 238Pu and 241 Am inhaled as nitrate to about 1% of that in untreated controls;
2 injection of DTPA is more effective than aerosolized DTPA for reducing deposits of 238 Pu and 241Am in the liver and skelton;
3 combined treatment involving early inhalation of DTPA followed by repeated intravenous injections is likely to be the most effective treatment for workers who have accidentally inhaled plutonium and americium nitrates.
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References
1.
Ballou, J.E., Dagle, G.E., McDonald, K.E. & Buschbom, R.L. (1977). Influence of inhaled Ca-DTPA on the long-term effects of inhaled Pu nitrate. Health Phys. , 32, 479-484.
2.
Dolphin, G.W. (1976). Review of some problems and recent research work associated with the use of chelating agents for the removal of incorporated radionuclides from humans. In Diagnosis and Treatment of Incorporated Radionuclides, pp. 403-418. Vienna: IAEA.
3.
Icrp (1979). Limits for Intakes of Radionuclides by Workers. Int. Comm. on Radiological Protection, Publication 30. Oxford: Pergamon Press.
4.
Keough, R.F. & Powers, G.J. (1970). Determination of plutonium in biological materials by extraction and liquid scintillation counting. Anal. Chem. , 42, 419-421.
5.
Lloyd, R.D., Mays, C.W., McFarland, S.A., Taylor, G.N. & Atherton, D.R. (1976). A comparison of Ca-DTPA and Zn-DTPA for chelating 241Am in beagles. Health Phys., 31, 281-284.
6.
Ncrp (1980). Management of persons accidentally contaminated with radionuclides. National Council on Radiation Protection and Measurements. NCRP Report No. 65.
7.
Nenot, J.C. & Stather, J.W. (1979). The Toxicity of Plutonium, Americium and Ceasium . Comm. of the Eur. Communities. Oxford : Pergamon Press (EUR 6157 EN, FR).
8.
Nenot, J.C., Morin, M. & Lafuma, J. (1971). Contaminations experimentales par l'americium en solution et leur traitment. Health Phys., 20, 383-391.
9.
Ohlenschlager, L., Schieferdecker, H. & Schmidt-Martin, W. (1978). Efficacy of Zn-DTPA and Ca-DTPA in removing plutonium from the human body. Health Phys., 35, 694-699.
10.
Planas-Bohne, F. & Ebel, H. (1975). Dependence of DTPA-toxicity on the treatment schedule . Health Phys., 29, 103-106.
11.
Planas-Bohne, F. & Olinger, H. (1976). On the influence of Ca-DTPA on the Zn- and Mn-concentrations in various organs of the rat. Health Phys., 31, 165-166.
12.
Ross, D.M. (1968). A statistical summary of United States Atomic Energy Commission contractors' internal exposure experience. In Diagnosis and Treatment of Deposited Radionuclides, eds H. A. Kornberg & W. D. Norwood, pp. 427-434. Amsterdam: Excerpta Medica Foundation.
13.
Schofield, G.B. & Lynn, J.C. (1973). A measure of the effectiveness of DTPA chelation therapy in cases of plutonium inhalation and plutonium wounds. Health Phys., 24, 317-327.
14.
Seidel, A. (1976). Removal of 252Cf and 241Am from the rat by means of Ca-DTPA and Zn-DTPA. In Diagnosis and Treatment of Incorporated Radionuclides, pp. 323-339. Vienna : IAEA.
15.
Stather, J.W., Smith, H., James, A.C. & Rodwell, P. (1976). The experimental use of aerosol and liposomal forms of Ca-DTPA as a treatment for plutonium contamination. In Proc. Seminar Diagnosis and Treatment of Incorporated Radionuclides , pp. 387-400. Vienna: IAEA.
16.
Stather, J.W., Smith, H., Bailey, A., Birchall, R.A. & Crawley, F.E.H. (1983). The retention of 14C-DTPA in human volunteers after inhalation or intravenous injection. Health Phys., 44, 45-52.
17.
Stradling, G.N., Cooper, J.R., Smith, H. & Ham, G.J. (1979). The use of DTPA for removing extrapulmonary 244Cm. Int. J. Nuc. Med. Biol., 6, 183-191.
18.
Stradling, G.N., Stather, J.W., Sumner, S.A., Moody, J.C. & Strong, J.C. (1984a). Decorporation of inhaled americium-241 dioxide and nitrate from hamsters using Zn-DTPA and Puchel. Health Phys., 46, 1296-1300.
19.
Stradling, G.N., Stather, J.W., Sumner, S.A., Strong, J.C., Lennox, J.C. & Ham, S.E. (1984b). Decorporation of inhaled plutonium nitrate from hamsters using Zn-DTPA. Health Phys., 46, 919-924.
20.
Strong, J.C., James, A.C. & Hodgson, A. (1977). A facility for exposing rodents by inhalation to industrial actinide dust. In Annual Research and Development Report 1976, pp. 19-21. Harwell: National Radiological Protection Board.
21.
Taylor, D.M. (1973). Chemical and physical properties of the transplutonium elements. In Uranium, Plutonium and Transplutonic Elements , eds H. C. Hodge, J. P. Stannard & J. B. Hursh, pp. 717-738. Berlin: Springer-Verlag.
22.
Taylor, G.N., Williams, J.L., Roberts, L., Atherton, D.R. & Shabestan, L. (1974). Increased toxicity of Na3 Ca-DTPA when given by protracted administration. Health Phys., 27, 285-288.
23.
Volf, V. (1978). Treatment of incorporated transuranium elements . Technical Report Series No. 184. Vienna: IAEA.
