1 The case histories are presented of three separate incidents of poisoning by ingestion of Hemlock Water Dropwort tubers (Oenanthe crocata). Two of these cases involved a fatality.
2 An analytical profile is provided for oenanthotoxin, the major toxic principal of the tubers. Chromatographic, spectroscopic and mass spectral data for related compounds are also given.
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References
1.
Anet, E.F.L.J., Lythgoe, B., Silk, M.H. & Trippett, S. (1953). Oenanthotoxin and cicutoxin. Isolation and structure . J. Chem. Soc., 62, 309-322.
2.
Anger, J.-P., Anger, F., Chauvel, Y., Girre, R.L., Curtes, N. & Curtes, J.-P. (1976). Intoxication mortelle par Oenanthe safranée (Oenanthe crocata). Eur. J. Toxicol., 9 (2), 119-125.
Bohlmann, F. & Rode, K.-M. (1968). Die Polyine aus Oenanthe crocata L. Chem. Ber., 101, 1163-1175.
5.
Clarke, E.G.C., Kidder, D.E. & Robertson, W.D. (1949). The isolation of the toxic principle of Oenanthe crocata. J. Pharm. Pharmacol., 1, 377-381.
6.
Coleman, M.P. (1978). Water hemlock poisoning. North Staffs. Med. Inst. J., 10, 28-29.
7.
Grundy, H.F. & Howarth, F. (1956). Pharmacological studies on hemlock water dropwort . Br. J. Pharmacol., 11, 225-230.
8.
Mitchell, M.I. & Routledge, P.A. (1978). Hemlock water dropwort poisoning: a review. Clin. Toxicol., 12 (4), 417-426.
9.
Vale, J.A. & Meredith, T.J. (1981). Poisonous plants and fungi . In Poisoning Diagnosis and Treatment, eds J. A. Vale & T. J. Meredith, pp. 193-201. London: Update Books.
