Dazoxiben,a Prototype Inhibitor of Thromboxane Synthesis,has Little Toxicity in Laboratory Animals

Abstract

1 Dazoxiben, an orally active specific inhibitor of thromboxane synthetase, was administered by mouth daily to dogs and rats for 6 months.

2 Dogs showed no evidence of toxicity up to 300 mg day^-1 kg^-1, the highest dose level used.

3 Rats showed no evidence of toxicity after 100 mg day^-1 kg^-1, but at 300 mg day^-1 kg^-1 there were slight increases in plasma calcium and urea concentrations and a moderate incidence of focal nephrosis; males showed a slightly increased platelet count.

4 Studies in rats and rabbits at dose levels up to 400 mg day^-1 kg^-1, by mouth, revealed no adverse effects on male or female fertility, embryogenesis, parturition or postnatal development.

5 As dazoxiben is well absorbed after oral administration, the generally negative outcome to these toxicity studies suggests that selective inhibitors of thromboxane synthesis may be largely free of adverse effects which might impede their therapeutic or prophylactic use in clinical medicine.