Fatal Self-poisoning with Benoxaprofen

Abstract

1 A report of the first fatal self-poisoning due to primary toxicity of benoxaprofen.

2 Benoxaprofen is toxic in acute overdosage to the central nervous system, myocardium and kidneys, but appears to spare the liver.

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References

Allen, J.R. (1983). Benoxaprofen and the skin. Br. J. Dermatol., 109, 361-364.

Allen, J.R. & Littlewood, S.M. (1982). Benoxaprofen: effect on cutaneous lesions in psoriasis. Br. Med. J., 285, 1241.

Chatfield, D.H. & Woodige, T.J. (1978). Determination of benoxaprofen in biological fluids . J. Chromatogr., 153, 101-105.

Court, H. & Volans, G.N. (1984). Poisoning after overdose with non-steroidal antiinflammatory drugs. Adv. Drug Ac. Pois. Rev., 3, 1-21.

Editorial (1982). Benoxaprofen. Br. Med. J., 285, 459-460.

Halsey, J.P. & Cardoe, N. (1982). Benoxaprofen; side effect profile in 300 patients . Br. Med. J., 284, 1365-1368.

Hindson, C. , Daymond, T. , Diffey, B. & Lawler, P. (1982). Side effects of benoxaprofen. Br. Med. J., 284, 1368-1369.

Lilley Research Laboratories, Data on File.

Rubin, A. , Rodda, B.E. , Warwick, P. , Ridolfo, A.W. & Gruber, C.M. (1971). Physiological disposition of fenoprofen in man. I: Pharmacokinetic comparison of calcium and sodium salts administered orally . J. Pharm. Sci., 60, 1797-1801.

10.

Smith, G.L. , Goulbourn, R.A. & Burt, R.A.P. (1977). Preliminary studies of absorption and excretion of benoxaprofen in man. Br. J. Clin. Pharmacol., 4, 585-590.

11.

Taggart, H. McA. & Alderice, J.M. (1982). Fatal cholestatic jaundice in elderly patients taking benoxaprofen. Br. Med. J., 284, 1372.