1 Cyanotic crises occurred in a breast-fed infant whose mother was under treatment with dipyrone for a sore throat. No abnormalities were found at physical and routine laboratory examinations.
2 Dipyrone concentrations in mother's serum and milk and in infant's serum and urine were 3.3, 4.3 and 3.2, 3.74 μg/ml respectively.
3 It is concluded that the adverse effect could be due to dipyrone ingested with mother's milk.
Get full access to this article
View all access options for this article.
References
1.
Bajoghli, M., Ajudani, T.S. & Gharavi, M. (1977). Generalized oedema of newborn associated with administration of dipyrone. Eur. J. Pediatr., 126, 271-274.
2.
Berlin, C.M. (1980). The excretion of drugs and chemicals in human milk. In Pediatric Pharmacology: Therapeutic Principles in Practice, pp. 137-147. New York: Grune and Stratton.
3.
Goodman, L.S. & Gilman, A. (1975). The Pharmacological Basis of Therapeutics, 5th edn, p. 348. New York: Macmillan.
4.
Snyder, R.D. (1975). Poisonings of the nervous system. In The Practice of Pediatric Neurology, pp. 1047-1067. St Louis: C. V. Mosby Co.
5.
Wilson, J.T., Brown, R.D., Cherek, D.R., Dailey, J.W.Hilman, B., Jobe, C., Manno, B.R., Manno, J.E., Redetzki, H.N. & Stewart, J.J. (1980). Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin. Pharmacokinet. , 5, 1-66.