1 The concentration-dependent inhibition of Neosampoon, a vaginal contraceptive, on ejaculated human sperm motility was studied with a transmembrane migration method.
2 Caffeine (5mM), glutathione (5mM) and glutathione (15mM) all reactivated the motility of Neosampoon-immobilized sperm.
3 Caffeine (5mM) was more potent than glutathione in antagonizing Neosampoon; there was no difference between the potency of 5mM- and 15mM-glutathione.
4 Human sperm motility could be a model for studying the interaction of membrane-active drugs, including the protective effect of glutathione against membrane-disrupting agents.
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