1 Displacement of amitriptyline by lidocaine was studied during haemoperfusion (HP) in five beagle dogs.
2 Clearance of amitriptyline during HP was 0.93, although the amount of amitriptyline removed was only 2% of the given dose. Lidocaine does therefore not improve amitriptyline yield during HP. Clearance of lidocaine during HP was 0.99. Almost 13% of the lidocaine given intravenously was removed by HP.
3 Lidocaine did not improve myocardial performance during HP in amitriptyline-intoxicated dogs.
4 At necropsy the highest concentrations of amitriptyline in this model were found in the brain and the lung. The amitriptyline/nortriptyline ratio was lowest in the liver and lung, suggesting that these two organs are major sites of metabolism.
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