Animal experiments have suggested that Puchel, a lipophilic derivative of DTPA may be of use in removing plutonium from humans after an accidental intake. This study reports toxicological findings in mice. After the administration of Puchel, as single or repeated doses of the pentasodium salt, an LD50/ld value of 530 ± 44 mg kg-1 was obtained.
Get full access to this article
View all access options for this article.
References
1.
Beyer, W. H. , ed. (1974). Handbook of tables for probability and statistics, 2nd edn. CRC Press.
2.
Bulman, R.A. & Griffin, R.J. (1981). Investigations into techniques for removing intracellular plutonium-111. Naturwissenchaften, 67, S.483.
3.
Bulman, R.A. , Stather, J.W., Strong, J.C., Rodwell, P., Griffin, R.J. & Hodgson, A. (1979). Further investigations into the use of Puchel for clearing actinides from lungs. NRPB R&D3, 128-130. London: HMSO.
4.
Catsch, A. (1964). Zut Toxikologie der Diathylenetriamin-pentaessigsaure . Naunyn-Schmiedberg's Arch. exp. Path. u. Pharmak., 246, 316-329.
5.
Hall, C.S. (1934). Emotional behaviour in the rat. 1. Defaecation and urination as measures of individual differences in emotionality. J. Comp. Physiol. Psychol., 18, 385-403.
6.
Loomis, T.A. (1968). Numbers in toxicology. Chap. 2 in Essentials of Toxicology. Philadelphia: Lea and Febiger.
7.
Morgan, R.M. (1973). Studies on the metabolism and toxicity of diethylenetriaminepentaacetic acid. PhD thesis, Sunderland Polytechnic.
8.
Morgan, R.M. & Smith, H. (1974a). The effect of acute and subacute treatment with diethylenetriaminepentaacetic acid on the hepatic function of mice. Toxicology, 2, 43-49.
9.
Morgan, R.M. & Smith, H. (1974b). Histological changes in kidney, liver and duodenum of the mouse following the acute and subacute administration of diethylenetriaminepentaacetic acid. Toxicology, 2, 153-163.
10.
Papworth, D. (1975). Maximum likelihood techniques of curve fitting . Appdx. to J. K. R. Savage. Radiation Botany, 15, 87-140.
11.
Reuber, M.D. (1967). Hepatic lesions in young rats given calcium disodium edeate. Toxicol. Appl. Pharmacol., 11, 321-326.
12.
Schofield, G.B. (1969). Comparisons in the medical management of three cases of Plutonium contaminated wounds. 163-172 in Handling of Radiation Accidents. Proc. Symposium, Vienna, May 1969. Vienna: IAEA.
13.
Silverman, P. (1978). Animal behaviour in the laboratory. London: Chapman and Hall.
14.
Smith H. & Bulman, R.A. (1981). Unpublished observations. Cited by Bulman & Griffin, 1981.
15.
Stather, J.W. , Bulman, R.A., Strong, J.C., Smith, H., Rodwell, P., Griffin, R.J. & Hodgson, A. (1978). The use of inhaled Puchel for increasing the elimination of plutonium from the body. NRPB R&D2, 115-117. London: HMSO.
16.
Stather, J.W. , Stradling, G.N., Smith, H., Payne, S., James, A.C., Strong, J.C., Ham, S.E., Sumner, S.A., Bulman, R.A., Hodgson, A., Towndrow, C. & Ellender, M. (1982). Decorporation of 238Pu02 from the hamster by inhalation of chelation agents. Health Physics, 42, 525-526.
17.
Stradling, G.N. , STATHER, J. W., HAM, S. E. & SUMNER, S. A. (1981). The use of Puchel and DTPA for removing 238Pu02 from the lungs of hamsters . Health Physics, 41, 387-391.
18.
Taylor, G.N. , Williams, J.C., Roberts, L., Atherton, D.R. & Shabestain, L. (1974). Increased toxicity of Na 3CaDTPA when given by protracted administration. Health Physics, 27, 285-288.
19.
Volf, V. (1978). Treatment of incorporated Transuranium Elements , Technical Report Series 184. Vienna: IAEA.
20.
Weber, K.M. (1969). The deleterious effects of EDTA and DTPA on the intestine of the rat. Z. Gesamte Exp. Med. einschl. Exp. Chir ., 150, 354-360.
