1 In 10 out of 25 patients admitted with carbamazepine overdosage to local teaching hospitals sufficient plasma level data of carbamazepine and two of its main metabolites (expoxide and dihydroxy) were obtained to characterize their terminal elimination kinetics.
2 Some other pharmacokinetic aspects which could be useful in extrapolating to the amount and time of ingestion of the overdose are discussed.
Get full access to this article
View all access options for this article.
References
1.
Aucamp, A.K. & Hundt, H.K.L. (1978). A study of carbamazepine and its epoxy- and hydroxy metabolites in serum and saliva of male and female epileptic patients. In Advances in Epileptology, eds H. Meinardi & A. J. Rowan, pp. 280-284. Amsterdam: Swets and Zeitlinger.
2.
Bertilsson, L. (1978). Clinical pharmacokinetics of carbamazepine. Clinical Pharmacokinetics3, 128-143.
3.
Hundt, H.K.L. & Clark, E.C. (1975). Thin-layer chromatographic method for determining carbamazepine and two of its metabolites in serum. J. Chromat. , 107, 149-154.
4.
Rosenberg, J., Benowitz, N.L. & Pond, S. (1981). Pharmacokinetics of drug overdose. Clinical Pharmacokinetics, 6, 161-192.