1 A young man developed reversible acute renal failure after a large overdose of phenazopyridine.
2 The renal failure was treated by peritoneal dialysis.
3 Analysis of blood and urine samples failed to demonstrate the parent drug but a metabolite with similar ultraviolet absorption was detected.
4 No parent drug or metabolites were detected in the peritoneal dialysate.
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References
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Gabor, E.P., Lowenstein, L. & De Leeuw, N.K.M. (1964). Hemolytic anemia induced by phenylazo-diamino-pyridine (Pyridium). Canad. Med. Ass. J., 91, 756-759.
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Johnson, W.J. & Chartrand, A. (1976). The metabolism and excretion of phenazopyridine hydrochloride in animals and man. Tox. and Appl. Pharmacol. , 37, 371-376.
