The plan of attack for this Commentary is threefold. First: to consider, place in perspective and judge some of the claims that have been advanced for resveratrol’s utility. Second: to evaluate and judge the scientific basis and validity of the paper being commented upon. The judgment is very positive. Third: to place in perspective the importance of hormesis in being a major factor determining resveratrol’s ultimate efficacy.
Howitz KT, Sinclair DAXenohormesis: sensing the chemical cues of other species. Cell2008; 133: 387-391.
2.
Pohorecky LABiphasic action of ethanol. Biobehav Rev1977; 1: 231-240.
3.
Rimm EB, Klatsky AL, Grobbee D., and Stampfer MJReview of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits?Br Med J1996; 312: 731-736.
4.
Gronbaek M.Epidemiologic evidence for the cardioprotective effects associated with consumption of alcoholic beverages. Pathophysiology2004 ; 10: 83-92.
5.
Calabrese EJ , Baldwin, LAThe frequency of U-shaped dose-responses in the toxicological literature. Toxicol Sci2001; 62: 330-338.
6.
Calabrese EJ , Baldwin, LAThe hormetic dose response model is more common than the threshold model in toxicology. Toxicol Sci2003; 71: 246-250.
7.
Azios NG, Krishnamoorthyy L., Harris M., Cubano LA, Cammer M., and Dharmawardhane SFEstrogen and resveratrol regulate rac and cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells . Neoplasia2007; 9: 147-158.
8.
Waters DJ, Shen S., Kengeri SS, et al. Selenium, apoptosis, and DNA damage: Defining the optimal selenium dose for human prostate cancer prevention. In: The Annual Meeting of the International Hormesis Society-Dose-Response 2009: Implications for Toxicology, Medicine and Risk Assessment. University of Massachusetts, Amherst, MA, 2009.
9.
Rayman MP, Combs GF Jr, and Waters DJSelenium and vitamin E supplementation for cancer prevention. JAMA2009; 301: 1876.
10.
Holick MFSunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr2004; 80: 1678S-1688S.
11.
Smith SM, Gardner KK, Locke J., and Zwart SRVitamin D supplementation during Antarctic winter. Am J Clin Nutr2009; 89: 1092-1098.
12.
Hayes DPVitamin D and ageing. Biogerontology2010; 11: 1-16.
13.
Aubin JE, Heersche JNM.Vitamin D and osteoblasts. In: Feldman D, Glorieux FH, Pike JW (eds) Vitamin D. San Diego: Academic Press, 1997, p.313-328.
14.
Zittermann A., Schleithoff SS, and Korfer R.Putting cardiovascular disease and vitamin D deficiency into perspective. Br J Nutr2005 ; 94: 483-492.
15.
Faeh D., Gutzwiller F., Bopp M., and Swiss National CohortStudy Group.Lower mortality from coronary heart disease and stroke at higher altitudes in Switzerland. Circulation2009; 120: 495-501.
16.
Zittermann A., Gummert JFSun, vitamin D, and cardiovascular disease . J Photochem Photobiol B2010 Jan 22 [Epub ahead of print].
17.
Tuohimaa P. , Tenkanen L., Ahonen M., et al. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer2004; 108: 104-108.
18.
Tuohimaa P.Vitamin D, aging, and cancer. Nutr Rev2008; 66: S147-S152.