The concept of hormesis, or low-dose U-shaped responses, is now well established in toxicology and pharmacology but requires development in medicine and therapeutics. In doing so, care must be taken to not confuse metaphorical and chemical uses of the term hormesis. Low dose, continuous adaptive responses are fundamentally different than conventional pharmacology, and they may improve the scientific underpinning for complementary medicine, nutrition and lifestyle therapies.
References
1.
Moerman D., Jonas WBDeconstructing the placebo effect and finding the meaning response. Ann Intern Med2002; 136: 471-476.
2.
Calabrese EJCancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses. Crit Rev Toxicol2005; 35: 463-582.
3.
Calabrese EJHormetic dose-response relationships in immunology: occurrence, quantitative features of the dose response, mechanistic foundations, and clinical implications. Crit Rev Toxicol2005; 35: 89-295.
4.
Calabrese EJ , Baldwin LAHormesis: U-shaped dose responses and their centrality in toxicology. Trends Pharmacol Sci2001; 22: 285-291.
5.
Calabrese EJ , Bachmann KA, Bailer AJ, Bolger PM, Borak J., Cai L., et al. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol2007; 222: 122-128.
6.
Calabrese EJConverging concepts: adaptive response, preconditioning, and the Yerkes-Dodson Law are manifestations of hormesis. Ageing Res Rev2008; 7: 8-20.
7.
Lamming D., Wood J., Sinclair D.Small molecules that regulate lifespan: evidence for xenohormesis. Mol Microbiol2004; 53: 1003-1009.
8.
Bland J.What role has nutrition been playing in our health? The xenohormesis connection . Integrative Med2007; 6: 22-24.
9.
Jonas WB, Lin Y., Tortella F.Neuroprotection from glutamate toxicity with ultra-low dose glutamate. Neuroreport2001; 12: 335-339.
10.
Hogberg G., Pagani M., Sundin O., Soares J., Aberg-Wistedt A., Tarnell B., et al. Treatment of post-traumatic stress disorder with eye movement desensitization and reprocessing: outcome is stable in 35-month follow-up . Psychiatry Res2008.
Gruber C., Wendt M., Sulser C., Lau S., Kulig M., Wahn U., et al. Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy. Allergy2007; 62: 1270-1276.
13.
Dalgard C., Christiansen L., Jonung T., Mackness MI, de Maat MP, Horder M.No influence of increased intake of orange and blackcurrant juices and dietary amounts of vitamin E on paraoxonase-1 activity in patients with peripheral arterial disease. Eur J Nutr2007; 46: 354-363.
14.
Walker TB, Altobelli SA, Caprihan A., Robergs RAFailure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men. Metabolism2007; 56: 1111-1117.
15.
Tepaske R., te Velthuis H., Oudemans-van Straaten HM, Bossuyt PM, Schultz MJ, Eijsman L., et al. Glycine does not add to the beneficial effects of perioperative oral immune-enhancing nutrition supplements in high-risk cardiac surgery patients . JPEN J Parenter Enteral Nutr2007; 31: 173-180.
16.
Chen H., Zhuo Q., Yuan W., Wang J., Wu T.Vitamin A for preventing acute lower respiratory tract infections in children up to seven years of age. Cochrane Database Syst Rev2008 (1): CD006090.
17.
Shankar AH, Jahari AB, Sebayang SK, Aditiawarman, Apriatni M, Harefa B., et al. Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial. Lancet2008; 371: 215-227.
18.
Subbiah MTNutrigenetics and nutraceuticals: the next wave riding on personalized medicine . Transl Res2007; 149: 55-61.
19.
Motter A., Gulbahce N., Almaas E., Barabasi A.Predicting synthetic rescues in metabolic network. Mol Systems Biol2008; 4: 1-10.