Motor neurone disease - a methyl bromide exposure cluster points to a causal mechanism

Abstract

References

Haverkamp LJ , Appel V. , Appel SH Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction. Brain 1995; 118: 707-719.

Rosen DR , Siddique T. , Patterson D. , et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993; 362: 59-62.

Fitzmaurice PS , Shaw IC , Mitchell JD Alteration of superoxide dismutase activity in the anterior horn in motoneuron disease patients. J Neurol Sci 1995; 129: 96-98.

Shaw IC , Fitzmaurice PS , Mitchell JD , Lynch PG Studies on cellular free radical protection mechanisms in the anterior horn from patients with amyotropic lateral sclerosis. Neurodegeneration 1995; 4: 391-396.

Fitzmaurice PS , Shaw IC , Kleiner HE , et al. Evidence for DNA damage in amyotrophic lateral sclerosis. Muscle Nerve 1996; 19: 797-798.

Shaw IC

Could exposure to methyl bromide cause motor neurone disease?

NZ Med J 2005; 118: 1208.

Kiddle E. Cluster investigation into motor neurone disease, Public Health Service, Nelson Marlborough District Health Board, Nelson, New Zealand - available at http://www.mnda.org.nz/resources.html

Shaw PJ Clinical review. Motor Neurone Disease. BMJ 1999; 318: 1118-1121.

Gansewendt B. , Xu D. , Foest U. , Hallier E. , Bolt HM , Peter H. DNA binding of methyl iodide in male and female F344 rats. Carcinogenesis 1991; 12, 463-467.