1 Barton HA Chiu WA Setzer RW Andersen ME Bailer AJ Bois FY . Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation. Toxicol Sci2007; 99: 395–402.
2.
2 Renwick AG Barlow SM Hertz-Piccioto I Boobis AR Dybing E Edler L . Risk characterization of chemicals in food and diet. Final part of Food Safety in Europe (FOSIE): risk assessment of chemicals in food and diet (EC concerted action QLK1-1999-00156). Food Chem Toxicol2003; 41: 1211–1271.
3.
3 Edler L . Uncertainty in biomonitoring and kinetic modelling. Ann NY Acad Sci1999; 895: 80–100.
4.
4 Lehman AJ Fitzhugh OG . Quaterly report to the editor on topics of current interest-100-fold margin of safety. Assoc Food Drug Off US Q Bull1954; 18: 33–35.
5.
5 Renwick AG Lazarus NR . Human variability and noncancer risk assessment – an analysis of the default uncertainty factor. Regul Toxicol Pharmacol1998; 27: 3–20.
6.
6 World Health Organization. Chemical specific adjustment factors for interspecies differences and human variability. Guidance document for use of data in dose/concentration – response assessment.Geneva: WHO; 2005.
7.
7 Dorne JCLM Renwick AG . The refinement of uncertainty/safety factors in risk assessment by the incorporation of data on toxicokinetic variability in humans. Toxicol Sci2005; 86: 20–26.
8.
9.
9 Chen JJ Moon H Kodell RL . A probabilistic frame work for non-cancer risk assessment model. Regul Toxicol Pharmacol2007; 48: 45–50.
10.
10 Kodell RL Chen JJ . On the use of hierarchical probabilistic models for characterizing and man aging uncertainty in risk/safety assessment. Risk Anal2007; 27: 433–437.