Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus

Abstract

Persistent organochlorine pollutants (POPs), such aspolychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in recent epidemiological studies. We have analysed 2,2',4,4',5,5' -hexachlorobiphenyl (CB-153) and p,p'-DDE in 544 serum-samples from Swedish women with a median age of 50 years. The participants were asked if they had diabetesand if so, what type of diabetes, years since diagnosis and what kind of treatment they had. Associations between exposure and T2DM were analysed by logistic regression. Moreover, trends of T2DM prevalence were tested with Jonckheere-Terpstra' test. Sixteen of the 544 women (3%) had diabetes, of which15 were classified as T2DM. There was a significant associationwith T2DM for both CB-153 (an increase of 100ng/glipid corresponded to an odds ratio [OR] of 1. 6, 95% confidenceinterval [CI] 1. 0, 2. 7) and p,p9-DDE (OR 1. 3, 95%CI 1. 1, 1. 6). In addition, significant positive trends betweenquartiles of CB-153 and T2DM (P 5 0. 004) and p,p9-DDEand T2DM (P 5 0. 002) were observed. The study showsan association between POP serum concentrations andan increased prevalence of T2DM. Human & Experimental Toxicology (2007) 26, 447—451

Keywords

dietary exposure PCB persistent organochlorine pollutants p,p'-DDE type 2 diabetes mellitus

References

King H. , Aubert RE , Herman WH Global burden of diabetes, 1995—2005. Diabetes Care 1998; 21: 1414—31.

O'Rahilly S. Science, medicine, and the future. Noninsulin dependent diabetes mellitus: the gathering storm. Br Med J 1997; 314: 955—59.

Uutisupa M.

Gene-diet interaction in relation to the prevention of obesity and type 2 diabetes: Evidencefrom the Finish Diabetes Prevention Study. Nutrition Metab

Cardiovasc Dis 2005; 15: 225—33.

Calvert GM , Sweeney MH , Deddens J. , Wall DK Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Occup Environ Med 1999; 56: 270—76.

Cramner M. , Louie S. , Kennedy RH , Kern PA et al. 2000. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) is associated with hyperinsulinemia andinsulin resistance. Toxicol Sci 2000; 56: 431—36.

Fierens S. , Mairesse H. , Heilier J-F. , De Burbure C. et al. Dioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: findings in a population-based study in Belgium. Biomarkers 2003; 8: 529—34.

Henriksen GL , Ketchum NS , Michalek JE , SwabyJA. Serum dioxin and diabetes mellitus in veteransof Operation Ranch Hand. Epidemiology 1997; 8:252—58.

Longnecker MP , Michalek JE Serum dioxin level inrelation to diabetes mellitus among Air Force veterans with background levels of exposure. Epidemiology 2000; 11: 44—48.

Morgan DP , Lin LI , Saikaly HH Morbidity and mortality in workers occupationally exposed to pesticides. Arch Environ Contam Toxicol 1980; 9: 349—52.

10.

Vasiliu O. , Cameron L. , Gardiner J. , DeGuire P. et al. Polybrominated Biphenyls, Polychlorinated Biphenyls, Body Weight and Incidence of Adult-onset Diabetes Mellitus. Epidemiology 2006; May 23.

11.

Svensson BG , Nilsson A. , Hansson M. Exposure to dioxins and dibenzofurans through the consumptionof fish. N Engl J Med 1991; 324: 8—12.

12.

Svensson BG , Nilsson A. , Jonsson E. , Schutz A. et al. Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen. Scand J Work Environ Health 1995 ; 21: 96—105.

13.

Glynn AW , Wolk A. , Aune M. , Atuma S. et al. Serum concentrations of organochlorines in men: a search for markers of exposure. Sci Total Environ 2000 ; 263: 197—208.

14.

Grimvall E. , Rylander L. , Nilsson-Ehle P. , Nilsson U. et al. Monitoring of polychlorinated biphenyls in human blood plasma with respect to age, lactation and fish consumption; methodology developments. Arch Environ Contam Toxicol 1997; 32: 329—36.

15.

Gladen BC , Longnecker MP , Schecter AJ Correlations among polychlorinated biphenyls, dioxins, and furansin humans . Am J Ind Med 1999; 35: 15—20.

16.

Sjödin A. , Hagmar L. , Klasson-Wehler E. , Björk J. et al. Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Lativian and Swedish men . Environ Health Perspect 2000; 108: 1035—41.

17.

Rylander L. , Rignell-Hydbom A. , Hagmar L. A cross sectional study of the association between organochlorine pollutants and diabetes. Environmental Health—A Global Access Science Source 2005; 4: 28.

18.

Rylander L. , Hagmar L. Mortality and cancer incidence among women with a high consumption of fatty fish contaminated with persistent organochlorine compounds. Scand J Work Environ Health 1995 ; 21:419—26.

19.

Axmon A. , Thulstrup AM , Rignell-Hydbom A. , PedersenHS et al. Time to pregnancy as a function of maleand female serum concentrations of 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE). Human Reprod 2005; 21: 657—65.

20.

Jönsson Bag , Rylander L. , Rignell-Hydbom A. , Giwercman A. et al. Determinants of Serum Concentrations of 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) in 3161 men and women from Greenland, Sweden, Poland and Ukraine. Environmental Health—A Global Access Science Source 2005; 4: 27.

21.

Rignell-Hydbom A. , Rylander L. , Giwercman A. , Jönsson B. et al. Effect of dietary exposure to CB-153 and p,p'-DDE on reproductive function in Swedish fishermen. Human Reprod 2004; 19: 2066—75.

22.

Rylander L. , Nilsson-Ehle P. , Hagmar L. A simplified precise method for adjusting serum levels of persistent organohalogen pollutants to total serum lipids . Chemosphere 2006; 62: 333—36.

23.

Greenland S. Modelling and variable selection in epidemiologic analysis. Am J Public Health 1989; 79:340—49.

24.

Eliasson M. , Lindahl B. , Lundberg V. , Stegamyr B. No increase in the prevalence of known diabetes between 1986 and 1999 in subjects 25—64 years of age in northern Sweden . Diabetic Medicine 2002; 19: 874—80.

25.

Sweeney MH , Calvert GA , Egeland GA , Fingerhut MA et al. Rewiev and update of the results of the NIOSH medical study of workers exposed to chemicals contaminated with 2,3,7,8-tetra-chlorodibenzop-dioxin . Teratog Carcinog Mutagen 1997; 84: 1540—43.

26.

Enan E. and Matsumura F. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced changes in glucose transporting activity in guinea pigs, mice and rats in vivo. J Biochem Toxicol 1094; 9: 97—106.

27.

Olsen H. , Enan E. , Matsumura F. Regulation of glucose transport in the NIH3T3 L1 preadipocyte cell line by TCDD. Environ Health Perspective 1994; 102: 454—58.

28.

Liu H. , Biegel L. , Narasimhan TR , Rowlands C. et al. Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxinand related compounds. Moll Cell Endocrinol 1992; 87: 1—3 and 19—28.

29.

Enan E. , Lasdley B. , Stewart D. , Overstreet J. et al. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) modulates function of human luteinizing granulosa cells via cAMP signaling and early reduction of glucose transporting activity. Reprod Toxicol 1996; 10: 191—98.

30.

Ebner K. , Brewster DW , Matsumura F. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on serum insulin and glucose levels in rabbits. J Environ Sci Health B 1988; 23: 427—38.

31.

Hokanson R. , Miller S. , Hennesey M. , Flesher M. et al. Disruption of estrogen-regulated gene expression by dioxin: down regulation of a gene associated with the onset of non-insulin-dependent diabetes mellitus (type2 diabetes). Hum Exp Toxicol 2004; 23: 55—564.

32.

Remillards RB , Bunce NJ Linking dioxins to diabetes: epidemiology and biologic plausibility. Environ Health Perspective 2002; 110: 853—58.

33.

Smith SA Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism. Biochem Soc Transaction 2001; 30: 1086—90.

34.

Vogel Cfa , Sciullo E. , Park S. , Liedtke C. et al. Dioxin increases C/EBPβ transcription by activating cAMP/-protein kinase A. J Biol Chem 2003; 18: 8886—94.

35.

Michalek J. , Ketchum N. , Tripathi R. Diabetes mellitus and 2,3,7,8-tetrachlorodibenzo-p-dioxin eliminationin veterans of Operation Ranch Hand. J Toxicol Environ Health 2003; 66: 211—21.