A model predictive control algorithm for double-hormone artificial pancreas based on optimal three-branch decision switching rules

Abstract

At present, double-hormone artificial pancreas is a hotspot in the research of regulating blood glucose level; however, there are few studies on switching mechanism of the subsystems for double-hormone artificial pancreas, and most of the existing studies rely on the prior knowledge of application fields. A model predictive control algorithm for double-hormone artificial pancreas based on optimal three-branch decision switching rules is proposed to solve this problem. The blood glucose controllers of insulin subsystems, zero infusion subsystems, and glucagon subsystems are constructed using model predictive control algorithms. Then, using the three-branch decision theory, switching rules between the three subsystems are designed, and the optimal switching threshold value can be solved by the mixed fruit fly algorithm. The algorithm can realize automatic acquisition of the threshold in the three-branch decision switching rules and gets rid of the dependence on the prior knowledge in the field of diabetes research. By the end, the UVa simulation platform is used to conduct experiments on 33 virtual patients and the simulation results verify that the proposed algorithm can control blood glucose effectively within the normal range and can achieve satisfactory performabce in error of tracking set point, safety, operation efficiency, group control quality, and system stability.