During the early postoperative period, it is important that the patient recovers without pain and inflammation, while preserving their quality of life. In this sense, coated titanium surfaces have been designed to release anti-inflammatory and analgesic drugs during the first postoperative hours.
Objective:
Evaluate the adsorption capacity and release profile of different bioactive titanium surfaces treated with three different drugs: acetaminophen, doxepin and ibuprofen.
Methods:
Four bioactive surfaces (polished, oxidized, hydroxyapatite precipitate, and polyvinyl alcohol coating surfaces) were physiochemically treated and analyzed.
Results:
Hydroxyapatite coatings were the roughest, while PVA coating was the softest. Acetaminophen was the only drug detected on all the surfaces. In contrast, higher drug doses were loaded into the PVA coatings, showing a satisfactory release profile.
Conclusion:
The results suggest that a rougher or ionically charged surface does not guarantee drug adsorption. In contrast, the use of a transport vehicle such as a polyvinyl coating ensures the release of the drug, initiating its therapeutic effect within the first minutes, and maintained for a period of between 120 and 180 min.
BrånemarkPHanssonBAdellR, et al.Osseointegrated implants in the treatment of the edentulous jaw. Scand J Plast Reconst Surg1977; 16: 1–132.
2.
AlbrektssonTBrånemarkPIHanssonHA,et al.Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand1981; 52: 155–170.
3.
Le GuéhennecLSoueidanALayrolleP, et al.Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater2007; 23: 844–854.
4.
AlbrektssonTWennerbergA. On osseointegration in relation to implant surfaces. Clin Implant Dent Relat Res2019; 21: –7.
5.
BotticelliDBerglundhTBuserD,et al.The jumping distance revisited: an experimental study in the dog. Clin Oral Implants Res2003; 14: 35–42.
6.
KellerJCSchneiderGBStanfordCM,et al.Effects of implant microtopography on osteoblast cell attachment. Implant Dent2003; 12: 175–181.
7.
Rosales-LealJIRodríguez-ValverdeMAMazzagliaG, et al.Effect of roughness, wettability and morphology of engineered titanium surfaces on osteoblast-like cell adhesion. Colloids Surf A Physicochem Eng Asp2010; 365: 222–229.
8.
Rivera-HernándezGAntunes-RicardoMMartínez-MoralesP,et al.Polyvinyl alcohol based-drug delivery systems for cancer treatment. Int J Pharm2021; 600: 120478.
9.
BarikAChakravortyN. Targeted drug delivery from titanium implants: a review of challenges and approaches. In: PokorskiM (eds) Trends in biomedical research, vol. 1251. Cham: Springer International Publishing, 2019, pp.1–17.
10.
PawlikAJaroszMSyrekK,et al.Co-delivery of ibuprofen and gentamicin from nanoporous anodic titanium dioxide layers. Colloids Surf B Biointerfaces2017; 152: 95–102.
11.
JaroszMPawlikASzuwarzyńskiM, et al.Nanoporous anodic titanium dioxide layers as potential drug delivery systems: drug release kinetics and mechanism. Colloids Surf B Biointerfaces2016; 143: 447–454.
12.
PawlikAJaroszMSochaRP,et al.The impacts of crystalline structure and different surface functional groups on drug release and the osseointegration process of nanostructured TiO(2). Molecules2021; 26: 1723.
13.
KravanjaKAFinšgarM. A review of techniques for the application of bioactive coatings on metal-based implants to achieve controlled release of active ingredients. Mater Des2022; 217: 110653.
14.
SandomierskiMJakubowskiMRatajczakM,et al.Titanium modification using bioactive titanate layer with divalent ions and coordinated ciprofloxacin – assessment of drug distribution using FT-IR imaging. Spectrochim Acta A Mol Biomol Spectrosc2024; 304: 123365.
15.
HickokNJShapiroIMChenAF. The impact of incorporating antimicrobials into implant surfaces. J Dent Res2018; 97: 14–22.
16.
BozziniBBarcaABoganiF, et al.Electrodeposition of nanostructured bioactive hydroxyapatite-heparin composite coatings on titanium for dental implant applications. J Mater Sci Mater Med2014; 25: 1425–1434.
17.
PawlikASochaRPHubalek KalbacovaM,et al.Surface modification of nanoporous anodic titanium dioxide layers for drug delivery systems and enhanced SAOS-2 cell response. Colloids Surf B Biointerfaces2018; 171: 58–66.
18.
WangBBianAJiaF, et al.“Dual-functional” strontium titanate nanotubes designed based on fusion peptides simultaneously enhancing anti-infection and osseointegration. Biomaterials Advances2022; 133: 112650.
19.
IonitaDBajenaru-GeorgescuDToteaG, et al.Activity of vancomycin release from bioinspired coatings of hydroxyapatite or TiO(2) nanotubes. Int J Pharm2017; 517: 296–302.
20.
YaoCWebsterTJ. Prolonged antibiotic delivery from anodized nanotubular titanium using a co-precipitation drug loading method. J Biomed Mater Res B Appl Biomater2009; 91: 587–595.
21.
SandomierskiMZielińskaMVoelkelA. A long-term controlled release of the drug for osteoporosis from the surface of titanium implants coated with calcium zeolite. Mater Chem Front2021; 5: 5718–5725.
22.
KazsokiASzabóPZelkóR. Prediction of the hydroxypropyl cellulose—poly(vinyl alcohol) ratio in aqueous solution containing papaverine hydrochloride in terms of drug loaded electrospun fiber formation. J Pharm Biomed Anal2017; 138: 357–362.
23.
WangXYucelTLuQ, et al.Silk nanospheres and microspheres from silk/pva blend films for drug delivery. Biomaterials2010; 31: 1025–1035.
24.
SalehiSBoddohiS. New formulation and approach for mucoadhesive buccal film of rizatriptan benzoate. Prog Biomater2017; 6: 175–187.
25.
AkaySYaghmurA. Recent advances in antibacterial coatings to combat orthopedic implant-associated infections. Molecules2024; 29: 1172.
26.
NiranjanRKaushikMPrakashJ, et al.Enhanced wound healing by PVA/Chitosan/Curcumin patches: in vitro and in vivo study. Colloids Surf B Biointerfaces2019; 182: 110339.
27.
PereiraGGGuterresSSBalducciAG, et al.Polymeric films loaded with vitamin E and aloe vera for topical application in the treatment of burn wounds. Biomed Res Int2014; 2014: 641590.
28.
AndrgieATDargeHFMekonnenTW, et al.Ibuprofen-loaded heparin modified thermosensitive hydrogel for inhibiting excessive inflammation and promoting wound healing. Polymers (Basel)2020; 12: 1–18.
29.
PatraSDeyJKarS, et al.Methotrexate-loaded surface-modified solid lipid nanoparticles targeting cancer expressing COX-2 enzyme. Langmuir2024; 40: 14811–14822.
30.
TrinhLTLimSLeeHJ,et al.Development of efficient sodium alginate/polysuccinimide-based hydrogels as biodegradable acetaminophen delivery systems. Gels2023; 9: 80.
31.
LaffleurFZilioMShuwisitkulD. Modified biomolecule as potential vehicle for buccal delivery of doxepin. Ther Deliv2016; 7: 683–689.
32.
EpsteinJBTrueloveELOienH, et al.Oral topical doxepin rinse: analgesic effect in patients with oral mucosal pain due to cancer or cancer therapy. Oral Oncol2001; 37: 632–637.
33.
LeenstraJLMillerRCQinR, et al.Doxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance]). J Clin Oncol2014; 32: 1571–1577.
34.
CastánHRuizMAClaresB,et al.Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia. Drug Deliv2015; 22: 869–876.
35.
ZahranRRosales LealJIRodríguez ValverdeMA,et al.Effect of hydrofluoric acid etching time on titanium topography, chemistry, wettability, and cell adhesion. PLoS One2016; 11: e0165296.
36.
Sánchez-TreviñoAYYGarcía-MartínezOBlasco-AvellanedaD, et al.Effect of the terminal group of phosphonate self-assembled films formed on Ti surfaces on the biomimetic layer formation and cell adhesion. Appl Surf Sci2016; 362: 304–314.
37.
KokuboTYamaguchiS. Novel bioactive materials developed by simulated body fluid evaluation: surface-modified Ti metal and its alloys. Acta Biomater2016; 44: 16–30.
38.
KimCKendallMRMillerMA, et al.Comparison of titanium soaked in 5M NaOH or 5M KOH solutions. Mater Sci Eng C Mater Biol Appl2013; 33: 327–339.
39.
XieYLiuXChuPK,et al.Nucleation and growth of calcium–phosphate on Ca-implanted titanium surface. Surf Sci2006; 600: 651–656.
40.
PhamMTMatzWReutherH, et al.Ion beam sensitizing of titanium surfaces to hydroxyapatite formation. Surf Coat Technol2000; 128: 313–319.
41.
JalotaSBhaduriSBTasAC. Effect of carbonate content and buffer type on calcium phosphate formation in SBF solutions. J Mater Sci Mater Med2006; 17: 697–707.
42.
MuñozMDCastánHRuizMA,et al.Design, development and characterization of transdermal patch of methadone. J Drug Deliv Sci Technol2017; 42: 255–260.
43.
HaoJ. Effect of surface roughness on droplet splashing. Phys Fluids2017; 29: 122105.
44.
JiangPZhangYHuR, et al.Advanced surface engineering of titanium materials for biomedical applications: from static modification to dynamic responsive regulation. Bioact Mater2023; 27: 15–57.
45.
Young KimSkyoung KimYSong ParkI, et al.Effect of alkali and heat treatments for bioactivity of TiO2 nanotubes. Appl Surf Sci2014; 321: 412–419.
46.
AnselmeKPlouxLPoncheA. Cell/material interfaces: influence of surface chemistry and surface topography on cell adhesion. J Adhes Sci Technol2010; 24: 831–852.
47.
HulkaIMirza-RoscaJCBuzduganD,et al.Microstructure and mechanical characteristics of Ti-Ta alloys before and after NaOH treatment and their behavior in simulated body fluid. Materials (Basel)2023; 16: 1943.
48.
SandomierskiMZielińskaMBuchwaldT, et al.Controlled release of the drug for osteoporosis from the surface of titanium implants coated with calcium titanate. J Biomed Mater Res B Appl Biomater2022; 110: 431–437.
49.
SundblomJGallinettiSBirgerssonU, et al.Gentamicin loading of calcium phosphate implants: implications for cranioplasty. Acta Neurochir (Wien)2019; 161: 1255–1259.
50.
KokuboTTakadamaH. How useful is SBF in predicting in vivo bone bioactivity?Biomaterials2006; 27: 2907–2915.
51.
SunFPangXZhitomirskyI. Electrophoretic deposition of composite hydroxyapatite–chitosan–heparin coatings. J Mater Process Technol2009; 209: 1597–1606.
52.
ZhaoDMWangYXChenZY, et al.Preparation and characterization of modified hydroxyapatite particles by heparin. Biomed Mater2008; 3: 025016.
53.
AvésEPEstévezGFSaderMS, et al.Hydroxyapatite coating by sol–gel on Ti–6Al–4V alloy as drug carrier. J Mater Sci Mater Med2009; 20: 543–547.
54.
StewartSADomínguez-RoblesJMcIlorumVJ, et al.Poly(caprolactone)-based coatings on 3D-printed biodegradable implants: a novel strategy to prolong delivery of hydrophilic drugs. Mol Pharm2020; 17: 3487–3500.
55.
Al-SahafZRaimi-AbrahamBLicciardiM,et al.Influence of polyvinyl alcohol (PVA) on PVA-poly-N-hydroxyethyl-aspartamide (PVA-PHEA) microcrystalline solid dispersion films. AAPS PharmSciTech2020; 21: 67.
56.
HazeriYIraniSZandiM,et al.Polyvinyl alcohol/sulfated alginate nanofibers induced the neuronal differentiation of human bone marrow stem cells. Int J Biol Macromol2020; 147: 946–953.
57.
Rubio-LaraJAIgarashiKJSoodS, et al.Expanding hematopoietic stem cell ex vivo: recent advances and technical considerations. Exp Hematol2023; 125–126: 6–15.
58.
GeevargheseRSajjadiSSHudeckiA, et al.Biodegradable and non-biodegradable biomaterials and their effect on cell differentiation. Int J Mol Sci2022; 23: 16185.
59.
MoreauDVillainABachyM, et al.In vivo evaluation of the bone integration of coated poly(vinyl-alcohol) hydrogel fiber implants. J Mater Sci Mater Med2017; 28: 1–11.
