It is often assumed that the promise of a monetary bonus improves cognitive control. We show that in fact appetitive motivation can also impair cognitive control, depending on baseline levels of dopamine-synthesis capacity in the striatum. These data not only demonstrate that appetitive motivation can have paradoxical detrimental effects for cognitive control but also provide a mechanistic account of these effects.
AartsE.RoelofsA.FrankeB.RijpkemaM.FernandezG.HelmichR. C.CoolsR. (2010). Striatal dopamine mediates the interface between motivational and cognitive control in humans: Evidence from genetic imaging. Neuropsychopharmacology, 35, 1943–1951.
2.
AartsE.RoelofsA.van TurennoutM. (2008). Anticipatory activity in anterior cingulate cortex can be independent of conflict and error likelihood. Journal of Neuroscience, 28, 4671–4678.
AshburnerJ.BarnesG.Chun-ChuanC.DaunizeauJ.FlandinG.FristonK.. . . PhillipsC. (2010). SPM8 manual. London, England: Wellcome Trust Centre for Neuroimaging, Functional Imaging Laboratory.
5.
BarnettV.LewisT. (1994). Outliers in statistical data (3rd ed.). West Sussex, England: John Wiley & Sons.
6.
BerridgeK. C.RobinsonT. E. (1998). What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience?Brain Research Reviews, 28, 309–369.
7.
BraemS.VergutsT.RoggemanC.NotebaertW. (2012). Reward modulates adaptations to conflict. Cognition, 125, 324–332.
8.
CoolsR.D’EspositoM. (2011). Inverted-U-shaped dopamine actions on human working memory and cognitive control. Biological Psychiatry, 69, e113–e125.
9.
CoolsR.FrankM. J.GibbsS. E.MiyakawaA.JagustW.D’EspositoM. (2009). Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration. Journal of Neuroscience, 29, 1538–1543.
10.
DayanP.NivY.SeymourB.DawN. D. (2006). The misbehavior of value and the discipline of the will. Neural Networks, 19, 1153–1160.
11.
DeJesusO. T. (2003). Positron-labeled DOPA analogs to image dopamine terminals. Drug Development Research, 59, 249–260.
12.
DickinsonA.BalleineB. W. (2002). The role of learning in the operation of motivational systems. In GallistelC. R. (Ed.), Stevens’ handbook of experimental psychology: Vol. 3. Learning, motivation and emotion (3rd ed., pp. 497–533). New York, NY: Wiley.
13.
EverittB. J.BelinD.EconomidouD.PellouxY.DalleyJ. W.RobbinsT. W. (2008). Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 3125–3135.
14.
HazyT. E.FrankM. J.O’ReillyR. C. (2006). Banishing the homunculus: Making working memory work. Neuroscience, 139, 105–118.
15.
JimuraK.LockeH. S.BraverT. S. (2010). Prefrontal cortex mediation of cognitive enhancement in rewarding motivational contexts. Proceedings of the National Academy of Sciences, USA, 107, 8871–8876.
16.
JordanS.EberlingJ. L.BankiewiczK. S.RosenbergD.CoxsonP. G.VanBrocklinH. F.. . . JagustW. J. (1997). 6-[18F]fluoro-l-m-tyrosine: Metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates. Brain Research, 750, 264–276.
17.
KishS. J.ZhongX. H.HornykiewiczO.HaycockJ. W. (1995). Striatal 3,4-dihydroxyphenylalanine decarboxylase in aging: Disparity between postmortem and positron emission tomography studies?Annals of Neurology, 38, 260–264.
18.
KrawczykD. C.GazzaleyA.D’EspositoM. (2007). Reward modulation of prefrontal and visual association cortex during an incentive working memory task. Brain Research, 1141, 168–177.
19.
LandauS. M.LalR.O’NeilJ. P.BakerS.JagustW. J. (2009). Striatal dopamine and working memory. Cerebral Cortex, 19, 445–454.
20.
LoganJ. (2000). Graphical analysis of PET data applied to reversible and irreversible tracers. Nuclear Medicine and Biology, 27, 661–670.
21.
MawlawiO.MartinezD.SlifsteinM.BroftA.ChatterjeeR.HwangD. R.. . . LaruelleM. (2001). Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D2 receptor parameter measurements in ventral striatum. Journal of Cerebral Blood Flow & Metabolism, 21, 1034–1057.
22.
MobbsD.HassabisD.SeymourB.MarchantJ. L.WeiskopfN.DolanR. J.FrithC. D. (2009). Choking on the money: Reward-based performance decrements are associated with midbrain activity. Psychological Science, 20, 955–962.
23.
PadmalaS.PessoaL. (2011). Reward reduces conflict by enhancing attentional control and biasing visual cortical processing. Journal of Cognitive Neuroscience, 23, 3419–3432.
24.
PatlakC. S.BlasbergR. G. (1985). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. Journal of Cerebral Blood Flow & Metabolism, 5, 584–590.
RobbinsT. W.EverittB. J. (1992). Functions of dopamine in the dorsal and ventral striatum. Seminars in Neuroscience, 4, 119–127.
27.
RobinsonT. E.BerridgeK. C. (2008). The incentive sensitization theory of addiction: Some current issues. Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 3137–3146.
28.
SasakiY.NanezJ. E.WatanabeT. (2010). Advances in visual perceptual learning and plasticity. Nature Reviews Neuroscience, 11, 53–60.
29.
SmithS. M.JenkinsonM.WoolrichM. W.BeckmannC. F.BehrensT. E. J.Johansen-BergH.. . . MatthewsP. M. (2004). Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage, 23(Suppl. 1), 208–219.
30.
VanBrocklinH. F.BlagoevM.HoeppingA.O’NeilJ. P.KloseM.SchubigerP. A.AmetameyS. (2004). A new precursor for the preparation of 6-[18F]fluoro-l-m-tyrosine ([18F]FMT): Efficient synthesis and comparison of radiolabeling. Applied Radiation and Isotopes, 61, 1289–1294.
31.
van SteenbergenH.BandG. P.HommelB. (2009). Reward counteracts conflict adaptation: Evidence for a role of affect in executive control. Psychological Science, 20, 1473–1477.
32.
VingerhoetsF. J.SnowB. J.SchulzerM.MorrisonS.RuthT. J.HoldenJ. E.. . . CaineD. B. (1994). Reproducibility of fluorine-18-6-fluorodopa positron emission tomography in normal human subjects. Journal of Nuclear Medicine, 35, 18–24.
33.
VolkowN. D.WangG. J.TelangF.FowlerJ. S.LoganJ.ChildressA. R.. . . WongC. (2006). Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction. Journal of Neuroscience, 26, 6583–6588.