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Abstract

The insula has been implicated as a component of central networks subserving evaluative and affective processes. This study examined evaluative valence and arousal ratings in response to picture stimuli in patients with lesions of the insula and two contrast groups: a control-lesion group (the primary contrast group) and an amygdala-lesion group. Patients rated the positivity and negativity of picture stimuli (from very unpleasant to very pleasant) and how emotionally arousing they found the pictures to be. Compared with patients in the control-lesion group, patients with insular lesions reported reduced arousal in response to both unpleasant and pleasant stimuli, as well as marked attenuation of valence ratings. In contrast, the arousal ratings of patients with amygdala lesions were selectively attenuated for unpleasant stimuli, and these patients’ positive and negative valence ratings did not differ from those of the control-lesion group. Results support the view that the insular cortex may play a broad role in integrating affective and cognitive processes, whereas the amygdala may have a more selective role in affective arousal, especially for negative stimuli.

Keywords

insula amygdala lesions evaluative processes valence arousal affect

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References

Adolphs

Russell

J.A.

Tranel

(1999). A role for the human amygdala in recognizing emotional arousal from unpleasant stimuli. Psychological Science, 10, 167–171.

Augustine

J.R.

(1996). Circuitry and functional aspects of the insular lobe in primates including humans. Brain Research Reviews, 22, 229–244.

Bechara

Damasio

(2005). The somatic marker hypothesis: A neural theory of economic decision. Games and Economic Behavior, 52, 336–372.

Bechara

Damasio

A.R.

(2003). Role of the amygdala in decision-making. Annals of the New York Academy of Sciences, 985, 356–369.

Bechara

Tranel

Damasio

Adolphs

Rockland

Damasio

A.R.

(1995). Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science, 269, 1115–1118.

Benton

A.L.

(1974). The Revised Visual Retention Test (4th ed.). New York, NY: Psychological Corp.

Berntson

G.G.

Bechara

Damasio

Tranel

Cacioppo

J.T.

(2007). Amygdala contribution to selective dimensions of emotion. Social Cognitive and Affective Neuroscience, 2, 123–129.

Berntson

G.G.

Sarter

Cacioppo

J.T.

(2003). Ascending visceral regulation of cortical affective information processing. European Journal of Neuroscience, 18, 2103–2109.

Britton

J.C.

Phan

K.L.

Taylor

S.F.

Welsh

R.C.

Berridge

K.C.

Liberzon

(2006). Neural correlates of social and nonsocial emotions: An fMRI study. NeuroImage, 31, 397–409.

10.

Clark

Bechara

Damasio

Aitken

M.R.

Sahakian

B.J.

Robbins

T.W.

(2008). Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making. Brain, 131, 1311–1322.

11.

Craig

A.D.

(2009). How do you feel—now? The anterior insula and human awareness. Nature Reviews Neuroscience, 10, 59–70.

12.

Critchley

H.D.

(2009). Psychophysiology of neural, cognitive and affective integration: fMRI and autonomic indicants. International Journal of Psychophysiology, 73, 88–94.

13.

Critchley

H.D.

Mathias

C.J.

Dolan

R.J.

(2002). Fear conditioning in humans: The influence of awareness and autonomic arousal on functional neuroanatomy. Neuron, 33, 653–663.

14.

Cunningham

W.A.

Raye

C.L.

Johnson

M.K.

(2004). Implicit and explicit evaluation: fMRI correlates of valence, emotional intensity, and control in the processing of attitudes. Journal of Cognitive Neuroscience, 16, 1717–1729.

15.

Hamann

S.B.

Ely

T.D.

Hoffman

J.M.

Kilts

C.D.

(2002). Ecstasy and agony: Activation of the human amygdala in positive and negative emotion. Psychological Science, 13, 135–141.

16.

Jabbi

Swart

Keysers

(2007). Empathy for positive and negative emotions in the gustatory cortex. NeuroImage, 34, 1744–1753.

17.

James

(1884). What is an emotion? Mind, 9, 188–205.

18.

Kluver

Bucy

P.C.

(1939). Preliminary analysis of functions of the temporal lobes in monkeys. Archives of Neurology and Psychiatry, 4, 979–1000.

19.

Knutson

Greer

S.M.

(2008). Anticipatory affect: Neural correlates and consequences for choice. Philosophical Transactions of the Royal Society B: Biological Sciences, 363, 3771–3786.

20.

Kuhnen

C.M.

Knutson

(2005). The neural basis of financial risk taking. Neuron, 47, 763–770.

21.

LaBar

K.S.

(2007). Beyond fear emotional memory mechanisms in the human brain. Current Directions in Psychological Science, 16, 173–177.

22.

LaBar

K.S.

LeDoux

J.E.

Spencer

D.D.

Phelps

E.A.

(1995). Impaired fear conditioning following unilateral temporal lobectomy in humans. Journal of Neuroscience, 15, 6846–6855.

23.

Lang

P.J.

Bradley

M.M.

Cuthbert

B.N.

(2008). International Affective Picture System (IAPS): Affective ratings of pictures and instruction manual (Tech. Rep. No. A-8). Gainesville, FL: University of Florida.

24.

Larsen

J.T.

McGraw

A.P.

Mellers

B.A.

Cacioppo

J.T.

(2004). The agony of victory and thrill of defeat: Mixed emotional reactions to disappointing wins and relieving losses. Psychological Science, 15, 325–330.

25.

LeDoux

(2003). The emotional brain, fear, and the amygdala. Cellular and Molecular Neurobiology, 23, 727–738.

26.

Norris

C.J.

Chen

E.E.

Zhu

D.C.

Small

S.L.

Cacioppo

J.T.

(2004). The interaction of social and emotional processes in the brain. Journal of Cognitive Neuroscience, 16, 1818–1829.

27.

Öhman

Carlsson

Lundqvist

Ingvar

(2007). On the unconscious subcortical origin of human fear. Physiology and Behavior, 92, 180–185.

28.

Phelps

E.A.

(2006). Emotion and cognition: Insights from studies of the human amygdala. Annual Review of Psychology, 57, 27–53.

29.

Pollatos

Gramann

Schandry

(2007). Neural systems connecting interoceptive awareness and feelings. Human Brain Mapping, 28, 9–18.

30.

Radloff

(1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385–401.

31.

Rolls

E.T.

Grabenhorst

Parris

B.A.

(2009). Neural systems underlying decisions about affective odors. Journal of Cognitive Neuroscience, 22, 1069–1082.

32.

Russell

Peplau

L.A.

Cutrona

C.E.

(1980). The revised UCLA Loneliness Scale: Concurrent and discriminant validity evidence. Journal of Personality and Social Psychology, 39, 472–480.

33.

Sabatinelli

Bradley

M.M.

Fitzsimmons

J.R.

Lang

P.J.

(2005). Parallel amygdala and inferotemporal activation reflect emotional intensity and fear relevance. NeuroImage, 24, 1265–1270.

34.

Saper

C.B.

(2002). The central autonomic nervous system: Conscious visceral perception and autonomic pattern generation. Annual Review of Neuroscience, 25, 433–469.

35.

Singer

Critchley

H.D.

Preuschoff

(2009). A common role of insula in feelings, empathy and uncertainty. Trends in Cognitive Sciences, 13, 334–340.

36.

Smith

B.W.

Mitchell

D.G.

Hardin

M.G.

Jazbec

Fridberg

Blair

R.J.

Ernst

(2009). Neural substrates of reward magnitude, probability, and risk during a wheel of fortune decision-making task. NeuroImage, 44, 600–609.

37.

Tranel

(2009). The Iowa-Benton school of neuropsychological assessment. In Grant

Adams

K.M.

(Eds.), Neuropsychological assessment of neuropsychiatric disorders (3rd ed., pp. 66–83). New York, NY: Oxford University Press.

38.

Wechsler

(1987). Wechsler Memory Scale—Revised manual. San Antonio, TX: Psychological Corp.

39.

Xue

Levin

I.P.

Bechara

(2010). The impact of prior risk experiences on subsequent risky decision-making: The role of the insula. NeuroImage, 50, 709–716.

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The Insula and Evaluative Processes

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